SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 ALA A 158
LEU A 159
LEU A 298
ALA A 297
LEU A 271
 None
 1.08A 1g5yB-2vwqA:
undetectable		 1g5yB-2vwqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		6 / 12 PRO A  53
GLY A  62
GLY A 122
ILE A 117
SER A 125
ALA A   5
 None
 1.19A 1sg9B-2vwqA:
4.1		 1sg9B-2vwqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 5 LEU A 135
PHE A 128
VAL A  69
ALA A  28
 None
 1.11A 2cizA-2vwqA:
undetectable		 2cizA-2vwqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 6 LEU A 187
SER A 183
ASP A  38
GLU A 150
 None
NAP  A 500 (-3.6A)
ZN  A 800 (-3.5A)
ZN  A 800 (-2.7A)
 1.05A 2j2pE-2vwqA:
undetectable
2j2pF-2vwqA:
undetectable		 2j2pE-2vwqA:
19.94
2j2pF-2vwqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 8 PRO A 173
VAL A 268
GLY A 267
TRP A 171
 None
 1.12A 2qd3A-2vwqA:
3.2		 2qd3A-2vwqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 10 ILE A 352
PRO A  85
SER A 130
VAL A  66
GLY A  67
 None
 1.42A 2qd4B-2vwqA:
2.8		 2qd4B-2vwqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		6 / 9 ALA A   5
VAL A  60
GLY A 122
GLY A  62
ILE A 352
ALA A   3
 None
 1.26A 2z0yA-2vwqA:
3.5		 2z0yA-2vwqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		6 / 9 ALA A   5
VAL A  60
GLY A 122
GLY A  62
ILE A 352
ALA A   3
 None
 1.21A 2z0yB-2vwqA:
2.3		 2z0yB-2vwqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 7 PRO A 173
SER A 174
VAL A 268
TRP A 171
 None
 1.50A 4kmmA-2vwqA:
undetectable		 4kmmA-2vwqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 7 GLY A 180
GLY A 182
SER A 183
ASP A 227
 NAP  A 500 ( 3.9A)
NAP  A 500 (-3.3A)
NAP  A 500 (-3.6A)
None
 0.74A 5ergB-2vwqA:
7.0		 5ergB-2vwqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 VAL A 299
LEU A 192
ALA A 162
SER A 165
LEU A 263
 None
 1.34A 5nd2B-2vwqA:
undetectable		 5nd2B-2vwqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 VAL A 299
LEU A 192
LEU A 159
ALA A 162
SER A 165
 None
 1.15A 5nd3B-2vwqA:
undetectable		 5nd3B-2vwqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		3 / 3 MET A   1
GLU A  22
ARG A  20
 None
 1.06A 5tjyA-2vwqA:
6.4		 5tjyA-2vwqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		3 / 3 MET A   1
GLU A  22
ARG A  20
 None
 1.10A 5tjzA-2vwqA:
6.4		 5tjzA-2vwqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		6 / 12 VAL A 299
LEU A 192
LEU A 159
ALA A 162
SER A 165
LEU A 263
 None
 1.47A 6b0iB-2vwqA:
undetectable		 6b0iB-2vwqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2vwq GLUCOSE
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 PRO A  13
GLY A  62
GLY A 122
VAL A  87
ALA A   3
 None
 1.03A 6nj9K-2vwqA:
4.3		 6nj9K-2vwqA:
20.76