SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 5 ARG A  12
ALA A  68
ASP A  41
GLY A  39
 None
 1.19A 1e7cA-2vwsA:
undetectable		 1e7cA-2vwsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 7 SER A  25
THR A 240
VAL A 238
ALA A  35
 None
 1.04A 1fo4B-2vwsA:
undetectable		 1fo4B-2vwsA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A 235
PRO A 177
ILE A  20
ALA A 223
ASP A  41
 None
 1.30A 2admA-2vwsA:
undetectable		 2admA-2vwsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A 235
PRO A 177
ILE A  20
ALA A 223
ASP A  41
 None
 1.34A 2admB-2vwsA:
undetectable		 2admB-2vwsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		3 / 3 THR A 112
SER A 145
LYS A  10
 None
 1.16A 3aocC-2vwsA:
undetectable		 3aocC-2vwsA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 7 VAL A 150
LEU A 180
LEU A 216
ILE A  96
 None
 0.97A 3gp0A-2vwsA:
undetectable		 3gp0A-2vwsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 7 GLY A  90
PHE A 174
PHE A 233
PHE A   9
 None
 1.15A 3ko0L-2vwsA:
undetectable
3ko0N-2vwsA:
undetectable		 3ko0L-2vwsA:
15.67
3ko0N-2vwsA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 7 PHE A   9
GLY A  90
PHE A 174
PHE A 233
 None
 1.13A 3ko0R-2vwsA:
undetectable
3ko0T-2vwsA:
undetectable		 3ko0R-2vwsA:
15.67
3ko0T-2vwsA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		5 / 12 GLY A 214
GLY A 230
LYS A 211
ALA A 209
ALA A 208
 None
 1.10A 3sueC-2vwsA:
undetectable		 3sueC-2vwsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 5 ALA A  50
ILE A  45
LEU A  24
ASN A  52
 None
 1.15A 4g19A-2vwsA:
undetectable		 4g19A-2vwsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 7 PHE A 215
ILE A 198
PRO A 177
HIS A 192
 None
 1.15A 4g5jA-2vwsA:
undetectable		 4g5jA-2vwsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE
(Escherichia
coli) 		4 / 4 CYH A 147
LEU A  13
LEU A 149
ALA A 212
 None
 1.05A 5hpuA-2vwsA:
undetectable
5hpuB-2vwsA:
undetectable		 5hpuA-2vwsA:
10.34
5hpuB-2vwsA:
7.33