SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 10 GLU A 213
ALA A 211
LEU A 220
GLU A 201
MET A 202
 None
 1.49A 1a29A-2vx2A:
undetectable		 1a29A-2vx2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 9 THR A 174
PRO A 175
GLY A 176
CYH A 183
GLY A 106
 None
 1.27A 1h4oC-2vx2A:
undetectable
1h4oD-2vx2A:
undetectable		 1h4oC-2vx2A:
22.66
1h4oD-2vx2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 ALA A  98
SER A 104
GLY A 106
HIS A 107
THR A  69
 None
 1.43A 2xffA-2vx2A:
0.0		 2xffA-2vx2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 4 ASN A  58
VAL A  93
THR A 233
ILE A 236
 None
 1.46A 4retA-2vx2A:
3.1		 4retA-2vx2A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 4 ASN A  58
VAL A  93
THR A 233
ILE A 236
 None
 1.46A 4retC-2vx2A:
undetectable		 4retC-2vx2A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 4 CYH A 155
LEU A 219
LEU A 190
ALA A 193
 None
 1.11A 5hpuA-2vx2A:
undetectable
5hpuB-2vx2A:
undetectable		 5hpuA-2vx2A:
6.27
5hpuB-2vx2A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		3 / 3 SER A 167
SER A 170
ALA A  98
 None
 0.69A 6dwnC-2vx2A:
undetectable		 6dwnC-2vx2A:
16.61