SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 GLY A 102
GLY A 106
HIS A 119
VAL A 160
 None
 0.90A 1dbbH-2vxoA:
undetectable
1dbbL-2vxoA:
undetectable		 1dbbH-2vxoA:
14.57
1dbbL-2vxoA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 PRO A 650
PRO A 687
GLY A 688
ARG A 638
 None
 0.75A 1h4oB-2vxoA:
undetectable		 1h4oB-2vxoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 PRO A 650
PRO A 687
GLY A 688
ARG A 638
 None
 0.74A 1h4oG-2vxoA:
undetectable		 1h4oG-2vxoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 ARG A 337
ARG A 446
ARG A 524
 XMP  A1694 (-4.2A)
None
None
 0.88A 1l7fA-2vxoA:
undetectable		 1l7fA-2vxoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 ARG A 337
ARG A 446
ARG A 524
 XMP  A1694 (-4.2A)
None
None
 0.89A 1l7hA-2vxoA:
undetectable		 1l7hA-2vxoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 PRO A 650
PRO A 687
GLY A 688
ARG A 638
 None
 0.76A 1oc3A-2vxoA:
undetectable		 1oc3A-2vxoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 VAL A 251
ARG A 600
HIS A 436
GLU A 430
 None
SO4  A1695 (-3.6A)
SO4  A1695 (-3.8A)
None
 1.11A 1s3zA-2vxoA:
undetectable
1s3zB-2vxoA:
undetectable		 1s3zA-2vxoA:
14.26
1s3zB-2vxoA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 246
ILE A 292
VAL A 251
ALA A 254
 None
SO4  A1697 (-3.2A)
None
None
None
 1.04A 1v2xA-2vxoA:
2.2		 1v2xA-2vxoA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 GLY A 106
GLY A  76
GLN A 108
ILE A 177
GLN A 188
 None
 1.36A 2akeA-2vxoA:
undetectable		 2akeA-2vxoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 GLY A 106
GLY A  76
GLN A 108
ILE A 177
GLN A 188
 None
 1.35A 2azxB-2vxoA:
undetectable		 2azxB-2vxoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 VAL A 666
VAL A 661
ASP A 539
 None
 0.76A 2fumD-2vxoA:
undetectable		 2fumD-2vxoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 4 LEU A 512
PRO A 513
LEU A 618
ARG A 677
 None
 1.39A 2hrcB-2vxoA:
3.1		 2hrcB-2vxoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 7 VAL A 133
PHE A 140
THR A 136
ARG A 141
 None
 0.94A 2kotA-2vxoA:
undetectable		 2kotA-2vxoA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 SER A 676
SER A 634
THR A 616
VAL A 561
VAL A 568
 None
 1.20A 2nniA-2vxoA:
undetectable		 2nniA-2vxoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 LEU A 256
LEU A 422
LEU A 411
ILE A 227
LEU A 426
 None
 1.05A 2ouzA-2vxoA:
undetectable		 2ouzA-2vxoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 LEU A 256
LEU A 260
GLN A 264
VAL A 362
LEU A 243
 None
 1.13A 2oz7A-2vxoA:
undetectable		 2oz7A-2vxoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 4 LEU A 512
PRO A 513
LEU A 618
ARG A 677
 None
 1.36A 2pnjB-2vxoA:
3.0		 2pnjB-2vxoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 11 LEU A 511
LEU A 618
ASN A 463
LEU A 466
VAL A 568
 None
 1.11A 2uxoB-2vxoA:
undetectable		 2uxoB-2vxoA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 6 LEU A 422
ALA A 254
LEU A 256
ALA A 259
 None
 0.98A 2vcvK-2vxoA:
undetectable		 2vcvK-2vxoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 5 PHE A 140
ALA A 178
GLY A 186
TYR A 185
 None
 1.15A 3bcrA-2vxoA:
undetectable		 3bcrA-2vxoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 GLY A 102
GLY A  76
GLY A 106
 None
 0.38A 3bogC-2vxoA:
undetectable		 3bogC-2vxoA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 4 LEU A 512
PRO A 513
LEU A 618
ARG A 677
 None
 1.17A 3hcoA-2vxoA:
2.2		 3hcoA-2vxoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 SER A 280
VAL A 351
ASP A 271
ILE A 297
ASN A 298
 None
 1.42A 3jb3A-2vxoA:
1.2		 3jb3A-2vxoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 ASP A 494
HIS A 505
LEU A 549
SER A 542
 None
 0.93A 3lm8B-2vxoA:
2.1
3lm8D-2vxoA:
2.3		 3lm8B-2vxoA:
14.49
3lm8D-2vxoA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 6 ILE A 339
PHE A 274
ALA A 444
ASN A 272
 None
 0.99A 3pgyA-2vxoA:
undetectable
3pgyB-2vxoA:
undetectable		 3pgyA-2vxoA:
22.74
3pgyB-2vxoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 7 ILE A 103
LEU A 101
SER A  52
LEU A 207
 None
 0.98A 3r9vA-2vxoA:
undetectable
3r9vB-2vxoA:
undetectable		 3r9vA-2vxoA:
17.80
3r9vB-2vxoA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 6 LEU A 443
PRO A 612
GLN A 610
PRO A 439
 None
None
XMP  A1694 (-3.0A)
XMP  A1694 (-4.1A)
 0.83A 3vkxA-2vxoA:
undetectable		 3vkxA-2vxoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 9 ILE A  54
ILE A  73
ILE A  74
MET A 110
ILE A 103
 None
 1.10A 3zosA-2vxoA:
undetectable		 3zosA-2vxoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 VAL A 636
TRP A 692
ILE A 448
LEU A 512
 None
 0.92A 4jq1B-2vxoA:
undetectable		 4jq1B-2vxoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 5 GLY A 383
SER A 382
ALA A 381
GLU A 334
 XMP  A1694 (-3.4A)
None
None
None
 1.04A 4m93B-2vxoA:
undetectable
4m93C-2vxoA:
undetectable		 4m93B-2vxoA:
16.08
4m93C-2vxoA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 LEU A 203
ASN A 205
ILE A 103
ALA A 187
ILE A  73
 None
 0.99A 4o2bD-2vxoA:
undetectable		 4o2bD-2vxoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 7 LEU A 507
ILE A 465
ILE A 468
VAL A 486
 None
 0.81A 4ojbA-2vxoA:
undetectable		 4ojbA-2vxoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 GLN A 632
HIS A 619
ARG A 622
 None
 1.06A 4qyqA-2vxoA:
undetectable		 4qyqA-2vxoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 GLN A 632
HIS A 619
ARG A 622
 None
 1.10A 4qyqB-2vxoA:
undetectable		 4qyqB-2vxoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 11 LEU A 411
LEU A 426
ASN A 257
ALA A 259
ILE A 230
 None
 1.10A 4x20D-2vxoA:
undetectable		 4x20D-2vxoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 LEU A 426
VAL A 247
ASP A 248
 None
None
SO4  A1697 (-4.4A)
 0.51A 4y8wC-2vxoA:
undetectable		 4y8wC-2vxoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 6 PHE A 545
HIS A 505
LEU A 543
LEU A 546
 None
 1.34A 5dzke-2vxoA:
undetectable
5dzks-2vxoA:
undetectable		 5dzke-2vxoA:
15.52
5dzks-2vxoA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 ILE A 649
PRO A 650
ILE A 641
 None
 0.42A 5hw8F-2vxoA:
undetectable		 5hw8F-2vxoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 7 HIS A 119
ILE A 173
VAL A 174
GLN A 108
 None
 1.18A 5kkzC-2vxoA:
undetectable
5kkzE-2vxoA:
undetectable		 5kkzC-2vxoA:
14.84
5kkzE-2vxoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		3 / 3 THR A 368
PRO A 437
ARG A 435
 None
 0.75A 5nd7B-2vxoA:
undetectable		 5nd7B-2vxoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 6 PRO A 617
VAL A 636
VAL A 561
ILE A 514
 None
 0.62A 5pbeA-2vxoA:
undetectable		 5pbeA-2vxoA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 ALA A 299
PHE A 438
ALA A 595
ALA A 591
THR A 587
 None
 1.11A 5tl8A-2vxoA:
undetectable		 5tl8A-2vxoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 10 PRO A 551
ASP A 458
PRO A 687
SER A 527
GLY A 518
 None
 1.21A 5weoA-2vxoA:
2.9
5weoD-2vxoA:
2.5		 5weoA-2vxoA:
21.82
5weoD-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 9 PRO A 551
ASP A 458
PRO A 687
SER A 527
GLY A 518
 None
 1.21A 5weoB-2vxoA:
2.4
5weoC-2vxoA:
2.6		 5weoB-2vxoA:
21.82
5weoC-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_C_CYZC1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 9 PRO A 687
SER A 527
GLY A 518
PRO A 551
ASP A 458
 None
 1.19A 5weoB-2vxoA:
2.5
5weoC-2vxoA:
2.6		 5weoB-2vxoA:
21.82
5weoC-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 9 PRO A 687
SER A 527
GLY A 518
PRO A 551
ASP A 458
 None
 1.22A 5weoA-2vxoA:
3.0
5weoD-2vxoA:
2.4		 5weoA-2vxoA:
21.82
5weoD-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 LEU A 203
ASN A 205
ILE A 103
ALA A 187
ILE A  73
 None
 0.99A 5xiwB-2vxoA:
2.3		 5xiwB-2vxoA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 8 ARG A 559
ARG A 638
ILE A 657
PRO A 653
 None
 1.11A 6a4iA-2vxoA:
undetectable		 6a4iA-2vxoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 12 ALA A 299
PHE A 438
ALA A 595
ALA A 591
THR A 587
 None
 1.02A 6aycA-2vxoA:
undetectable		 6aycA-2vxoA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 6 GLY A 273
ASN A 272
ASP A 271
ARG A 589
 None
 0.75A 6dwdA-2vxoA:
undetectable
6dwdC-2vxoA:
undetectable		 6dwdA-2vxoA:
23.76
6dwdC-2vxoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 5 GLY A 273
ASN A 272
ASP A 271
ARG A 589
 None
 0.74A 6dwdB-2vxoA:
undetectable
6dwdD-2vxoA:
undetectable		 6dwdB-2vxoA:
23.76
6dwdD-2vxoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		4 / 5 ARG A 589
GLY A 273
ASN A 272
ASP A 271
 None
 0.71A 6dwjB-2vxoA:
1.5
6dwjD-2vxoA:
1.5		 6dwjB-2vxoA:
23.76
6dwjD-2vxoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 9 ILE A 340
GLY A 442
LEU A 443
GLY A 245
ASN A 272
 None
 1.08A 6nm4B-2vxoA:
undetectable		 6nm4B-2vxoA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens) 		5 / 9 ILE A 340
GLY A 442
LEU A 443
GLY A 246
ASN A 272
 None
None
None
SO4  A1697 (-3.2A)
None
 1.29A 6nm4B-2vxoA:
undetectable		 6nm4B-2vxoA:
13.62