SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 0.98A 1fkbA-2vxpA:
undetectable		 1fkbA-2vxpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.08A 2dg3A-2vxpA:
undetectable		 2dg3A-2vxpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.01A 2dg4A-2vxpA:
undetectable		 2dg4A-2vxpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 10 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.94A 2riwA-2vxpA:
undetectable
2riwB-2vxpA:
undetectable		 2riwA-2vxpA:
17.07
2riwB-2vxpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.91A 2xn5A-2vxpA:
undetectable		 2xn5A-2vxpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 10 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.86A 2xn6A-2vxpA:
undetectable
2xn6B-2vxpA:
undetectable		 2xn6A-2vxpA:
16.67
2xn6B-2vxpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 THR A 530
LEU A 531
VAL A 624
GLY A 623
ILE A 573
 None
 1.04A 3bf1A-2vxpA:
undetectable
3bf1B-2vxpA:
undetectable		 3bf1A-2vxpA:
23.25
3bf1B-2vxpA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 GLY A 582
GLY A 581
LEU A 597
GLY A 574
ASP A 617
 None
 1.08A 4fp9F-2vxpA:
undetectable		 4fp9F-2vxpA:
19.61