SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 11 ILE A1069
ALA A 869
PHE A1067
SER A1011
ILE A 935
 None
 1.19A 1dg5A-2vxrA:
undetectable		 1dg5A-2vxrA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 9 TYR A1269
GLY A1244
PHE A1288
LEU A1270
ILE A1273
 None
 1.28A 1oltA-2vxrA:
0.0		 1oltA-2vxrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN A1007
GLU A1293
GLY A1294
PHE A1061
 None
None
GOL  A2005 (-3.6A)
None
 0.75A 1ykiA-2vxrA:
undetectable
1ykiB-2vxrA:
undetectable		 1ykiA-2vxrA:
16.02
1ykiB-2vxrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 PHE A1061
ASN A1007
GLU A1293
GLY A1294
 None
None
None
GOL  A2005 (-3.6A)
 0.77A 1ykiA-2vxrA:
undetectable
1ykiB-2vxrA:
undetectable		 1ykiA-2vxrA:
16.02
1ykiB-2vxrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN A1007
GLU A1293
GLY A1294
PHE A1061
 None
None
GOL  A2005 (-3.6A)
None
 0.76A 1ykiC-2vxrA:
undetectable
1ykiD-2vxrA:
undetectable		 1ykiC-2vxrA:
16.02
1ykiD-2vxrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 PHE A1061
ASN A1007
GLU A1293
GLY A1294
 None
None
None
GOL  A2005 (-3.6A)
 0.78A 1ykiC-2vxrA:
undetectable
1ykiD-2vxrA:
undetectable		 1ykiC-2vxrA:
16.02
1ykiD-2vxrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 6 ASP A1172
TYR A1173
TYR A1175
LEU A1176
 None
 1.16A 2w98A-2vxrA:
undetectable
2w98B-2vxrA:
undetectable		 2w98A-2vxrA:
20.20
2w98B-2vxrA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 LYS A 943
TYR A1142
ASN A1134
PRO A1131
 GOL  A2005 (-4.0A)
None
None
None
 1.47A 3bjwD-2vxrA:
undetectable		 3bjwD-2vxrA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 GLY A 885
ASP A 882
SER A 872
 None
 0.67A 3brfA-2vxrA:
7.1		 3brfA-2vxrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 4 ILE A1245
GLN A1114
ILE A1118
LEU A1280
 None
 1.35A 3dzyD-2vxrA:
undetectable		 3dzyD-2vxrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 10 ILE A 960
PHE A1050
ILE A1064
ILE A 935
LEU A 873
 None
 1.31A 3o1xA-2vxrA:
undetectable		 3o1xA-2vxrA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 TYR A1107
ASP A1179
ASP A1183
 None
 0.73A 3ou6B-2vxrA:
undetectable		 3ou6B-2vxrA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 ARG A1272
ARG A1271
ILE A1277
 None
 0.93A 4b7qA-2vxrA:
undetectable		 4b7qA-2vxrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 ARG A1272
ARG A1271
ILE A1277
 None
 0.91A 4b7qC-2vxrA:
undetectable		 4b7qC-2vxrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 7 TYR A1146
LEU A1145
ASN A1007
TYR A 944
 None
 1.20A 4f8yC-2vxrA:
undetectable
4f8yD-2vxrA:
undetectable		 4f8yC-2vxrA:
15.67
4f8yD-2vxrA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 10 ILE A1069
ALA A 869
PHE A1067
SER A1011
ILE A 935
 None
 1.15A 4g8zX-2vxrA:
undetectable		 4g8zX-2vxrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN A1001
ARG A1132
ASN A1141
ILE A1140
 None
 0.88A 4k0bA-2vxrA:
undetectable		 4k0bA-2vxrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN A1001
ARG A1132
ASN A1141
ILE A1140
 None
 0.88A 4l7iA-2vxrA:
undetectable		 4l7iA-2vxrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 4 ILE A1153
ILE A1167
ARG A1160
TYR A1102
 None
 1.48A 4zzbC-2vxrA:
0.0		 4zzbC-2vxrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 4 ILE A1153
ILE A1167
ARG A1160
TYR A1102
 None
 1.48A 4zzcC-2vxrA:
0.0		 4zzcC-2vxrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 4 ILE A1153
ILE A1167
ARG A1160
TYR A1102
 None
 1.48A 4zzcD-2vxrA:
undetectable		 4zzcD-2vxrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 5 ILE A 978
LYS A1065
ILE A1064
VAL A1062
 None
 1.01A 5jmnA-2vxrA:
undetectable		 5jmnA-2vxrA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 10 TYR A 996
ILE A 973
ILE A 979
ILE A1012
ILE A1014
 None
 1.08A 5murE-2vxrA:
undetectable		 5murE-2vxrA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 10 TYR A 996
ILE A 979
ILE A1024
ILE A1012
ILE A1014
 None
 0.91A 5murE-2vxrA:
undetectable		 5murE-2vxrA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 6 GLY A1148
VAL A1188
PHE A1288
PHE A1243
 None
 0.91A 6h7lA-2vxrA:
undetectable		 6h7lA-2vxrA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2vxr BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 6 GLY A1148
VAL A1188
PHE A1288
PHE A1243
 None
 0.92A 6h7lB-2vxrA:
undetectable		 6h7lB-2vxrA:
9.60