SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2vxx STARVATION INDUCED
DNA BINDING PROTEIN
(Synechococcus
elongatus) 		4 / 7 GLU A 107
LYS A  49
TYR A  47
HIS A  50
 None
 1.50A 4uciB-2vxxA:
undetectable		 4uciB-2vxxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2vxx STARVATION INDUCED
DNA BINDING PROTEIN
(Synechococcus
elongatus) 		5 / 12 THR A 147
ALA A 139
ASP A 144
GLU A 140
LEU A 142
 None
 1.35A 4xi3A-2vxxA:
undetectable		 4xi3A-2vxxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2vxx STARVATION INDUCED
DNA BINDING PROTEIN
(Synechococcus
elongatus) 		5 / 12 ALA A 127
PRO A 106
GLN A  48
LYS A  49
SER A  39
 None
 1.22A 5hfjC-2vxxA:
undetectable		 5hfjC-2vxxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vxx STARVATION INDUCED
DNA BINDING PROTEIN
(Synechococcus
elongatus) 		4 / 6 ILE A 129
LEU A  80
PHE A  40
HIS A  76
 None
 1.01A 5vkqB-2vxxA:
3.8
5vkqC-2vxxA:
4.0		 5vkqB-2vxxA:
7.33
5vkqC-2vxxA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vxx STARVATION INDUCED
DNA BINDING PROTEIN
(Synechococcus
elongatus) 		4 / 6 ILE A 129
LEU A  80
PHE A  40
HIS A  76
 None
 1.00A 5vkqC-2vxxA:
4.0
5vkqD-2vxxA:
4.0		 5vkqC-2vxxA:
7.33
5vkqD-2vxxA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2vxx STARVATION INDUCED
DNA BINDING PROTEIN
(Synechococcus
elongatus) 		3 / 3 TYR A  70
ASP A  68
GLN A  67
 None
None
ZN  A 201 ( 4.8A)
 0.81A 6g1pA-2vxxA:
undetectable		 6g1pA-2vxxA:
21.55