SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		6 / 12 GLY A  18
ILE A  89
ALA A 113
GLY A 110
ALA A 114
ILE A 117
 None
None
None
CIT  A 401 (-4.0A)
None
None
 1.46A 1bx4A-2vxyA:
8.2		 1bx4A-2vxyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		3 / 3 THR A 109
PRO A  75
THR A 111
 CIT  A 401 (-3.6A)
None
None
 0.95A 1dscC-2vxyA:
undetectable		 1dscC-2vxyA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 11 THR A 160
VAL A 194
VAL A 131
LEU A 261
ILE A 311
 None
 1.46A 1t6zA-2vxyA:
2.2		 1t6zA-2vxyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A 227
ILE A 254
ALA A 252
ILE A 164
PHE A 315
 None
 1.19A 1ve3A-2vxyA:
3.5		 1ve3A-2vxyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 7 ARG A 141
LYS A 142
LEU A 145
GLN A 146
 None
 0.95A 2eijP-2vxyA:
undetectable
2eijW-2vxyA:
undetectable		 2eijP-2vxyA:
18.09
2eijW-2vxyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 10 GLY A  18
GLY A 110
THR A 109
ALA A 113
ALA A 114
 None
CIT  A 401 (-4.0A)
CIT  A 401 (-3.6A)
None
None
 1.08A 2ej3B-2vxyA:
undetectable		 2ej3B-2vxyA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 8 GLY A  18
GLY A 110
THR A 109
ALA A 113
ALA A 114
 None
CIT  A 401 (-4.0A)
CIT  A 401 (-3.6A)
None
None
 1.10A 2ej3C-2vxyA:
undetectable		 2ej3C-2vxyA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 6 MET A 226
ARG A  29
ARG A 191
VAL A 307
 None
 1.25A 2qd4A-2vxyA:
3.6		 2qd4A-2vxyA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 10 THR A 160
ILE A 162
PHE A 100
THR A 313
ILE A 197
 None
 1.28A 2y7wB-2vxyA:
undetectable		 2y7wB-2vxyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A 110
ILE A 117
ALA A 147
VAL A 101
VAL A 163
 CIT  A 401 (-4.0A)
None
None
None
None
 0.93A 2yqzB-2vxyA:
4.2		 2yqzB-2vxyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 ILE A 151
GLY A 104
ALA A 147
ALA A  26
VAL A 131
 None
 1.05A 2yvlA-2vxyA:
4.1		 2yvlA-2vxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 ILE A 151
GLY A 104
ALA A 147
ALA A  26
VAL A 131
 None
 1.04A 2yvlB-2vxyA:
3.3		 2yvlB-2vxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 ILE A 151
GLY A 104
ALA A 147
ALA A  26
VAL A 131
 None
 1.04A 2yvlD-2vxyA:
3.6		 2yvlD-2vxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 7 ARG A 141
LYS A 142
LEU A 145
GLN A 146
 None
 0.90A 2zxwC-2vxyA:
undetectable
2zxwJ-2vxyA:
undetectable		 2zxwC-2vxyA:
18.09
2zxwJ-2vxyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 PRO A 165
MET A 226
ILE A 228
LEU A 249
LEU A 190
 None
 1.13A 3a50D-2vxyA:
undetectable		 3a50D-2vxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 8 GLY A 314
THR A 313
GLY A 256
ALA A 257
 None
 0.71A 3aruA-2vxyA:
3.0		 3aruA-2vxyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 8 ARG A 141
LYS A 142
LEU A 145
GLN A 146
 None
 0.96A 3asoC-2vxyA:
undetectable
3asoJ-2vxyA:
undetectable		 3asoC-2vxyA:
18.09
3asoJ-2vxyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 ILE A  89
ALA A  63
ALA A  42
VAL A  43
ASN A  44
 None
 1.08A 3jb3A-2vxyA:
undetectable		 3jb3A-2vxyA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 6 ILE A 298
ASP A 213
ILE A 293
GLY A 295
 None
 0.87A 3n3iA-2vxyA:
undetectable		 3n3iA-2vxyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A  18
ALA A 103
ILE A  17
PHE A 100
VAL A  27
 None
 1.01A 3nvkI-2vxyA:
4.0		 3nvkI-2vxyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 8 PRO A 165
PRO A 135
GLN A 144
GLU A 139
 None
 1.11A 3oyaA-2vxyA:
undetectable		 3oyaA-2vxyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 6 MET A 226
ARG A  29
ARG A 191
VAL A 307
 None
 1.11A 4mk4B-2vxyA:
4.1		 4mk4B-2vxyA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 11 GLY A 227
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.85A 4njvB-2vxyA:
undetectable		 4njvB-2vxyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 11 GLY A 227
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.87A 4njvC-2vxyA:
undetectable		 4njvC-2vxyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 9 ALA A 126
ILE A 197
VAL A 194
GLY A 130
VAL A  16
 None
 1.28A 4r20B-2vxyA:
undetectable		 4r20B-2vxyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 9 PHE A 315
ILE A 245
VAL A 282
GLY A 227
VAL A 260
 None
 1.28A 4r20B-2vxyA:
undetectable		 4r20B-2vxyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 ALA A  71
GLY A  20
ILE A 151
MET A 105
GLY A 106
 CIT  A 401 (-3.5A)
CIT  A 401 (-3.5A)
None
None
None
 1.06A 4r29D-2vxyA:
undetectable		 4r29D-2vxyA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 7 GLU A  91
ILE A  89
ILE A  41
MET A  59
 None
 0.92A 4xumA-2vxyA:
undetectable		 4xumA-2vxyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
CIT  A 401 (-3.6A)
CIT  A 401 (-3.5A)
None
 0.88A 5d4uA-2vxyA:
3.7		 5d4uA-2vxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
CIT  A 401 (-3.6A)
CIT  A 401 (-3.5A)
None
 0.89A 5d4uB-2vxyA:
undetectable		 5d4uB-2vxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
CIT  A 401 (-3.6A)
CIT  A 401 (-3.5A)
None
 0.91A 5d4uC-2vxyA:
undetectable		 5d4uC-2vxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
CIT  A 401 (-3.6A)
CIT  A 401 (-3.5A)
None
 0.85A 5d4uD-2vxyA:
undetectable		 5d4uD-2vxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		4 / 5 PRO A 115
ALA A 118
ALA A 157
LEU A 161
 None
 0.74A 5jncD-2vxyA:
undetectable		 5jncD-2vxyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2vxy CELL DIVISION
PROTEIN FTSZ
(Bacillus
subtilis) 		5 / 11 ALA A 240
VAL A 194
ILE A 197
ASN A 263
ILE A 162
 None
 1.13A 5y80A-2vxyA:
undetectable		 5y80A-2vxyA:
12.57