SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ILE A  47
VAL A  21
GLY A  44
LEU A  75
 None
 0.73A 1dzmA-2vycA:
undetectable		 1dzmA-2vycA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 SER A 537
VAL A 536
LEU A 531
PRO A 478
 None
 1.06A 1fduB-2vycA:
4.7		 1fduB-2vycA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 8 PHE A 476
ILE A 578
PHE A 580
PHE A 457
VAL A 559
 None
 1.43A 1fslA-2vycA:
undetectable		 1fslA-2vycA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 PRO A 370
MET A 366
ALA A 365
GLU A 348
 None
 1.46A 1qhyA-2vycA:
3.4		 1qhyA-2vycA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 332
ASN A 329
TRP A 528
 None
 1.16A 1r15C-2vycA:
undetectable		 1r15C-2vycA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 332
ASN A 329
TRP A 528
 None
 1.18A 1r15D-2vycA:
undetectable		 1r15D-2vycA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 332
ASN A 329
TRP A 528
 None
 1.17A 1r15E-2vycA:
undetectable		 1r15E-2vycA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 332
ASN A 329
TRP A 528
 None
 1.14A 1r15F-2vycA:
undetectable		 1r15F-2vycA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 564
ILE A 568
VAL A 569
PRO A 570
 None
 1.06A 1rxcC-2vycA:
undetectable		 1rxcC-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 564
ILE A 568
VAL A 569
PRO A 570
 None
 1.05A 1rxcD-2vycA:
undetectable		 1rxcD-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 564
ILE A 568
VAL A 569
PRO A 570
 None
 1.06A 1rxcF-2vycA:
undetectable		 1rxcF-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 564
ILE A 568
VAL A 569
PRO A 570
 None
 1.08A 1rxcL-2vycA:
undetectable		 1rxcL-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A  48
PHE A  45
ALA A  46
LEU A   4
 None
 0.92A 1ukbA-2vycA:
3.5		 1ukbA-2vycA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.44A 1v54A-2vycA:
undetectable
1v54C-2vycA:
undetectable		 1v54A-2vycA:
21.37
1v54C-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.42A 1v54N-2vycA:
2.3
1v54P-2vycA:
undetectable		 1v54N-2vycA:
21.37
1v54P-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.44A 1v55A-2vycA:
undetectable
1v55C-2vycA:
undetectable		 1v55A-2vycA:
21.37
1v55C-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 2dyrA-2vycA:
undetectable
2dyrC-2vycA:
undetectable		 2dyrA-2vycA:
21.37
2dyrC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.44A 2dyrN-2vycA:
undetectable
2dyrP-2vycA:
undetectable		 2dyrN-2vycA:
21.37
2dyrP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 2dysN-2vycA:
undetectable
2dysP-2vycA:
undetectable		 2dysN-2vycA:
21.37
2dysP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.44A 2eijA-2vycA:
undetectable
2eijC-2vycA:
undetectable		 2eijA-2vycA:
21.37
2eijC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.42A 2eijN-2vycA:
undetectable
2eijP-2vycA:
undetectable		 2eijN-2vycA:
21.37
2eijP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.46A 2eikA-2vycA:
undetectable
2eikC-2vycA:
undetectable		 2eikA-2vycA:
21.37
2eikC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.44A 2eikN-2vycA:
undetectable
2eikP-2vycA:
undetectable		 2eikN-2vycA:
21.37
2eikP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.45A 2eilA-2vycA:
2.3
2eilC-2vycA:
undetectable		 2eilA-2vycA:
21.37
2eilC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 2eilN-2vycA:
undetectable
2eilP-2vycA:
undetectable		 2eilN-2vycA:
21.37
2eilP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.45A 2eimA-2vycA:
undetectable
2eimC-2vycA:
undetectable		 2eimA-2vycA:
21.37
2eimC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.47A 2eimN-2vycA:
undetectable
2eimP-2vycA:
undetectable		 2eimN-2vycA:
21.37
2eimP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 2einA-2vycA:
undetectable
2einC-2vycA:
undetectable		 2einA-2vycA:
21.37
2einC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.45A 2einN-2vycA:
undetectable
2einP-2vycA:
undetectable		 2einN-2vycA:
21.37
2einP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 THR A 560
ILE A 538
LEU A 618
MET A 615
MET A 638
 None
 1.39A 2n27A-2vycA:
undetectable		 2n27A-2vycA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ALA A 354
TYR A 353
TYR A 360
MET A 530
 None
 1.06A 2pncA-2vycA:
undetectable		 2pncA-2vycA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 TRP A 474
GLY A 635
PHE A 601
PHE A 476
 None
 0.95A 2qmzA-2vycA:
6.9
2qmzB-2vycA:
6.8		 2qmzA-2vycA:
15.99
2qmzB-2vycA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 TRP A 474
GLY A 635
PHE A 601
PHE A 476
 None
 0.98A 2qwxA-2vycA:
7.0
2qwxB-2vycA:
6.7		 2qwxA-2vycA:
16.10
2qwxB-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 TRP A 474
GLY A 635
PHE A 601
PHE A 476
 None
 1.01A 2qx4A-2vycA:
2.2
2qx4B-2vycA:
undetectable		 2qx4A-2vycA:
15.99
2qx4B-2vycA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 TRP A 474
GLY A 635
PHE A 601
PHE A 476
 None
 0.95A 2qx6A-2vycA:
7.0
2qx6B-2vycA:
undetectable		 2qx6A-2vycA:
15.99
2qx6B-2vycA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A   9
GLN A  70
ARG A  73
 None
 0.91A 2w3bB-2vycA:
2.9		 2w3bB-2vycA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.42A 2y69A-2vycA:
undetectable
2y69C-2vycA:
undetectable		 2y69A-2vycA:
21.37
2y69C-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.40A 2zxwA-2vycA:
undetectable
2zxwC-2vycA:
undetectable		 2zxwA-2vycA:
21.37
2zxwC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.41A 2zxwN-2vycA:
undetectable
2zxwP-2vycA:
undetectable		 2zxwN-2vycA:
21.37
2zxwP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.44A 3abkN-2vycA:
undetectable
3abkP-2vycA:
undetectable		 3abkN-2vycA:
21.37
3abkP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.39A 3abmN-2vycA:
undetectable
3abmP-2vycA:
undetectable		 3abmN-2vycA:
21.37
3abmP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.45A 3ag1N-2vycA:
undetectable
3ag1P-2vycA:
undetectable		 3ag1N-2vycA:
21.37
3ag1P-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.42A 3ag2N-2vycA:
undetectable
3ag2P-2vycA:
undetectable		 3ag2N-2vycA:
21.37
3ag2P-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.46A 3ag4N-2vycA:
undetectable
3ag4P-2vycA:
undetectable		 3ag4N-2vycA:
21.37
3ag4P-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 SER A  50
LEU A  57
GLY A  44
GLU A  52
 None
 1.21A 3aiaA-2vycA:
3.1
3aiaB-2vycA:
3.0		 3aiaA-2vycA:
12.72
3aiaB-2vycA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.45A 3asnA-2vycA:
undetectable
3asnC-2vycA:
undetectable		 3asnA-2vycA:
21.37
3asnC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 TRP A 350
VAL A 586
ARG A 588
 PLP  A1386 (-4.0A)
None
None
 0.88A 3b0wA-2vycA:
undetectable		 3b0wA-2vycA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 4 GLU A 739
GLY A 740
THR A 741
GLU A 742
 None
 1.22A 3e9xA-2vycA:
undetectable		 3e9xA-2vycA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 685
PHE A 710
THR A 738
THR A 741
 None
 0.99A 3mdrA-2vycA:
undetectable		 3mdrA-2vycA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 9 PHE A 411
PHE A 379
ASN A 407
ALA A 405
THR A 377
 None
 1.34A 3t3sA-2vycA:
0.0		 3t3sA-2vycA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 PRO A 478
ILE A 359
TRP A 518
PHE A 495
 None
 1.30A 3topB-2vycA:
1.5		 3topB-2vycA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 564
ILE A 568
VAL A 569
PRO A 570
 None
 1.07A 4e1vB-2vycA:
undetectable		 4e1vB-2vycA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLN A 577
THR A 573
THR A 560
THR A 552
 None
 1.00A 4mbsA-2vycA:
undetectable		 4mbsA-2vycA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 TRP A 474
GLY A 635
PHE A 601
PHE A 476
 None
 1.05A 4qogA-2vycA:
6.9
4qogB-2vycA:
7.0		 4qogA-2vycA:
16.10
4qogB-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 594
PHE A 580
ILE A 534
PHE A 582
 None
 1.09A 4y4dA-2vycA:
undetectable		 4y4dA-2vycA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 VAL A  35
LYS A  37
VAL A   3
LEU A  24
ALA A 120
 None
 1.46A 4ygfG-2vycA:
undetectable		 4ygfG-2vycA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 262
LYS A 268
PRO A 269
GLU A 667
 None
 1.32A 4z4gA-2vycA:
3.1		 4z4gA-2vycA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.40A 5b1aN-2vycA:
undetectable
5b1aP-2vycA:
undetectable		 5b1aN-2vycA:
21.37
5b1aP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.40A 5b1bN-2vycA:
undetectable
5b1bP-2vycA:
undetectable		 5b1bN-2vycA:
21.37
5b1bP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 5b3sN-2vycA:
undetectable
5b3sP-2vycA:
undetectable		 5b3sN-2vycA:
21.37
5b3sP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 PHE A 521
HIS A 363
LEU A 531
PRO A 284
 None
 1.44A 5csyB-2vycA:
undetectable		 5csyB-2vycA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 476
ALA A 556
PRO A 541
LEU A 539
 None
 1.12A 5dzkD-2vycA:
undetectable
5dzkR-2vycA:
undetectable		 5dzkD-2vycA:
14.97
5dzkR-2vycA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 PHE A 476
ALA A 556
PRO A 541
LEU A 539
 None
 1.14A 5dzkF-2vycA:
undetectable
5dzkT-2vycA:
undetectable		 5dzkF-2vycA:
14.97
5dzkT-2vycA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.40A 5iy5A-2vycA:
undetectable
5iy5C-2vycA:
undetectable		 5iy5A-2vycA:
21.37
5iy5C-2vycA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 THR A 381
HIS A 382
ALA A 349
ASP A 347
 None
None
PLP  A1386 (-3.4A)
PLP  A1386 (-2.8A)
 1.33A 5mfxA-2vycA:
3.3		 5mfxA-2vycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLN A 577
GLY A 280
ILE A 282
TYR A 655
 None
 1.12A 5vlmC-2vycA:
undetectable		 5vlmC-2vycA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.40A 5x19N-2vycA:
undetectable
5x19P-2vycA:
undetectable		 5x19N-2vycA:
21.37
5x19P-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 5x1bN-2vycA:
undetectable
5x1bP-2vycA:
undetectable		 5x1bN-2vycA:
21.37
5x1bP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.43A 5x1fN-2vycA:
undetectable
5x1fP-2vycA:
undetectable		 5x1fN-2vycA:
21.37
5x1fP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.41A 5zcqN-2vycA:
undetectable
5zcqP-2vycA:
undetectable		 5zcqN-2vycA:
21.37
5zcqP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A  54
GLU A  81
HIS A  80
VAL A  86
 None
 1.16A 6j20A-2vycA:
undetectable		 6j20A-2vycA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.38A 6nknA-2vycA:
undetectable
6nknC-2vycA:
undetectable		 6nknA-2vycA:
21.37
6nknC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.38A 6nmfN-2vycA:
undetectable
6nmfP-2vycA:
undetectable		 6nmfN-2vycA:
21.37
6nmfP-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.38A 6nmpA-2vycA:
undetectable
6nmpC-2vycA:
undetectable		 6nmpA-2vycA:
21.37
6nmpC-2vycA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A 382
ASP A 362
TYR A 360
HIS A 398
 None
 1.36A 6nmpN-2vycA:
undetectable
6nmpP-2vycA:
undetectable		 6nmpN-2vycA:
21.37
6nmpP-2vycA:
16.90