SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2vyf REPLICATIVE DNA
HELICASE
(Geobacillus
kaustophilus) 		4 / 8 LEU A 205
ARG A 202
PHE A 200
GLY A 185
 None
 0.97A 1fapB-2vyfA:
undetectable		 1fapB-2vyfA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2vyf REPLICATIVE DNA
HELICASE
(Geobacillus
kaustophilus) 		4 / 6 PRO A  40
PHE A  52
GLU A  73
VAL A  58
 None
 1.25A 1l2iB-2vyfA:
undetectable		 1l2iB-2vyfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2vyf REPLICATIVE DNA
HELICASE
(Geobacillus
kaustophilus) 		5 / 10 GLY A  84
VAL A  83
LEU A  89
LEU A  92
ALA A  47
 None
 1.27A 1pbcA-2vyfA:
undetectable		 1pbcA-2vyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 2vyf REPLICATIVE DNA
HELICASE
(Geobacillus
kaustophilus) 		5 / 10 ALA A 220
ASP A 320
ILE A 237
PRO A 356
ILE A 358
 None
 0.96A 3nu6A-2vyfA:
undetectable		 3nu6A-2vyfA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2vyf REPLICATIVE DNA
HELICASE
(Geobacillus
kaustophilus) 		3 / 3 ALA A 209
GLN A 419
GLY A 422
 None
 0.44A 4odoC-2vyfA:
undetectable		 4odoC-2vyfA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2vyf REPLICATIVE DNA
HELICASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A  30
LEU A  33
ALA A  34
PHE A  52
LEU A  21
 None
 1.09A 5k9dA-2vyfA:
undetectable		 5k9dA-2vyfA:
23.42