SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KW4_A_TICA600_1 (CYTOCHROME P450 2B4)	2vyw	HEMOGLOBIN (Fasciola hepatica)	5 / 11	ILE A 133 ILE A 32 THR A 19 ILE A 76 GLY A 72	None	0.95A	3kw4A-2vywA: undetectable	3kw4A-2vywA: 16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2D_F_LFXF102_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	2vyw	HEMOGLOBIN (Fasciola hepatica)	3 / 4	ARG A 65 GLY A 63 GLU A 62	None	0.67A	4z2dB-2vywA: undetectable 4z2dC-2vywA: undetectable	4z2dB-2vywA: 16.91 4z2dC-2vywA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_1_BEZ1801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	2vyw	HEMOGLOBIN (Fasciola hepatica)	3 / 3	LEU A 78 PHE A 120 ILE A 76	None	0.70A	5dzk1-2vywA: undetectable 5dzkF-2vywA: undetectable 5dzkM-2vywA: undetectable	5dzk1-2vywA: 2.53 5dzkF-2vywA: 20.80 5dzkM-2vywA: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESG_A_1YNA701_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2vyw	HEMOGLOBIN (Fasciola hepatica)	5 / 12	GLU A 134 PHE A 109 GLY A 95 LEU A 78 MET A 141	None HEM A 149 (-4.3A) None None HEM A 149 (-3.9A)	1.27A	5esgA-2vywA: undetectable	5esgA-2vywA: 13.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3KW4_A_TICA600_1","CYTOCHROME P450 2B4","2vyw","HEMOGLOBIN","Fasciola hepatica",5,"ILE A 133;ILE A  32;THR A  19;ILE A  76;GLY A  72","None","0.95A","3kw4A-2vywA:undetectable","3kw4A-2vywA:16.32"],["4Z2D_F_LFXF102_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","2vyw","HEMOGLOBIN","Fasciola hepatica",3,"ARG A  65;GLY A  63;GLU A  62","None","0.67A","4z2dB-2vywA:undetectable;4z2dC-2vywA:undetectable","4z2dB-2vywA:16.91;4z2dC-2vywA:22.27"],["5DZK_1_BEZ1801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","2vyw","HEMOGLOBIN","Fasciola hepatica",3,"LEU A  78;PHE A 120;ILE A  76","None","0.70A","5dzk1-2vywA:undetectable;5dzkF-2vywA:undetectable;5dzkM-2vywA:undetectable","5dzk1-2vywA:2.53;5dzkF-2vywA:20.80;5dzkM-2vywA:22.96"],["5ESG_A_1YNA701_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2vyw","HEMOGLOBIN","Fasciola hepatica",5,"GLU A 134;PHE A 109;GLY A  95;LEU A  78;MET A 141","None;HEM A 149 (-4.3A);None;None;HEM A 149 (-3.9A)","1.27A","5esgA-2vywA:undetectable","5esgA-2vywA:13.41"]]