SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		5 / 12 LEU A  68
GLY A 122
LEU A 130
HIS A  88
PHE A 161
 None
 1.42A 1brpA-2vzaA:
undetectable		 1brpA-2vzaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		5 / 12 PHE A 173
PHE A 214
SER A 146
LEU A 207
VAL A 201
 None
 1.38A 1q23C-2vzaA:
undetectable		 1q23C-2vzaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 6 PRO A 244
PHE A 266
LEU A 268
ILE A 275
 None
 1.09A 1sbrA-2vzaA:
undetectable
1sbrB-2vzaA:
undetectable		 1sbrA-2vzaA:
22.82
1sbrB-2vzaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 7 LEU A 136
LEU A 139
LEU A 151
GLU A 150
 None
 0.92A 2vq5B-2vzaA:
undetectable		 2vq5B-2vzaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		5 / 10 ILE A 276
ILE A 275
VAL A 270
LYS A 271
GLY A 272
 None
 1.23A 3em0A-2vzaA:
undetectable		 3em0A-2vzaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		3 / 3 GLY A 122
PRO A 160
LEU A 155
 None
 0.54A 3hcpB-2vzaA:
undetectable		 3hcpB-2vzaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 8 HIS A  88
ASP A  64
THR A  65
LEU A 130
 None
 1.23A 3wg7A-2vzaA:
undetectable
3wg7C-2vzaA:
2.3
3wg7P-2vzaA:
undetectable		 3wg7A-2vzaA:
19.13
3wg7C-2vzaA:
24.10
3wg7P-2vzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 8 LEU A 225
ARG A 224
GLU A 264
HIS A 281
 None
 1.36A 3zmdA-2vzaA:
undetectable
3zmdB-2vzaA:
undetectable		 3zmdA-2vzaA:
22.44
3zmdB-2vzaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 6 ASN A 145
GLU A 174
LEU A 213
PHE A 186
 None
 1.11A 4twdB-2vzaA:
undetectable
4twdC-2vzaA:
undetectable		 4twdB-2vzaA:
20.29
4twdC-2vzaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 6 ASN A 145
GLU A 174
LEU A 213
PHE A 186
 None
 1.13A 4twdD-2vzaA:
undetectable
4twdE-2vzaA:
undetectable		 4twdD-2vzaA:
20.29
4twdE-2vzaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vza CELL FILAMENTATION
PROTEIN
(Bartonella
henselae) 		4 / 6 ASN A 145
GLU A 174
LEU A 213
PHE A 186
 None
 1.10A 4twdI-2vzaA:
undetectable
4twdJ-2vzaA:
undetectable		 4twdI-2vzaA:
20.29
4twdJ-2vzaA:
20.29