SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A   9
GLU A  77
ASP A 132
LEU A  22
GLY A  78
 None
 1.20A 1d4fA-2vzbA:
undetectable		 1d4fA-2vzbA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A   9
GLU A  77
ASP A 132
LEU A  22
GLY A  78
 None
 1.24A 1d4fB-2vzbA:
undetectable		 1d4fB-2vzbA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A   9
GLU A  77
ASP A 132
LEU A  22
GLY A  78
 None
 1.26A 1d4fC-2vzbA:
undetectable		 1d4fC-2vzbA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A   9
GLU A  77
ASP A 132
LEU A  22
GLY A  78
 None
 1.23A 1d4fD-2vzbA:
undetectable		 1d4fD-2vzbA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 8 LEU A  18
GLU A 146
ALA A 139
THR A 135
 None
FE  A6204 ( 2.5A)
None
None
 0.86A 1ie4B-2vzbA:
undetectable
1ie4D-2vzbA:
undetectable		 1ie4B-2vzbA:
25.14
1ie4D-2vzbA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 11 GLU A  62
HIS A  65
GLU A 114
ILE A 142
GLU A 146
 FE  A6205 ( 2.5A)
FE  A6204 (-3.3A)
FE  A6205 (-2.0A)
None
FE  A6204 ( 2.5A)
 0.81A 1rnrA-2vzbA:
7.2		 1rnrA-2vzbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 GLU A  62
HIS A  65
GLU A 114
ILE A 142
GLU A 146
 FE  A6205 ( 2.5A)
FE  A6204 (-3.3A)
FE  A6205 (-2.0A)
None
FE  A6204 ( 2.5A)
 0.82A 1rnrB-2vzbA:
6.0		 1rnrB-2vzbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 7 ALA A  66
TYR A 121
ILE A 142
HIS A 149
 None
None
None
FE  A6205 (-3.3A)
 1.08A 2zm7A-2vzbA:
undetectable		 2zm7A-2vzbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 5 HIS A 141
ILE A 142
HIS A  65
LEU A  68
 None
None
FE  A6204 (-3.3A)
None
 1.26A 3qpkA-2vzbA:
undetectable		 3qpkA-2vzbA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 5 ALA A 117
GLU A  62
GLU A  29
ALA A  32
 FE  A6205 ( 4.9A)
FE  A6205 ( 2.5A)
FE  A6204 (-1.9A)
None
 1.40A 3r9tC-2vzbA:
undetectable		 3r9tC-2vzbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 7 VAL A  51
LEU A 157
ASN A 108
ILE A 160
 None
 1.01A 3rfmA-2vzbA:
2.3		 3rfmA-2vzbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 PHE A  55
GLY A  45
ALA A  46
SER A 103
LEU A 107
 None
 1.08A 4e1gB-2vzbA:
undetectable		 4e1gB-2vzbA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 6 LEU A  22
GLU A  29
ILE A  74
PRO A  84
 None
FE  A6204 (-1.9A)
None
None
 1.07A 4xi3C-2vzbA:
undetectable		 4xi3C-2vzbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		4 / 5 GLU A  29
ALA A  25
GLU A  28
GLU A 146
 FE  A6204 (-1.9A)
None
None
FE  A6204 ( 2.5A)
 1.09A 5dwkC-2vzbA:
3.4		 5dwkC-2vzbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASN A 110
SER A 113
SER A 112
 None
 0.70A 5gsnA-2vzbA:
undetectable		 5gsnA-2vzbA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_1
(ALPHA-GLUCOSIDASE)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 HIS A 149
GLU A 145
HIS A 141
GLU A  29
GLU A  62
 FE  A6205 (-3.3A)
None
None
FE  A6204 (-1.9A)
FE  A6205 ( 2.5A)
 1.39A 5hqaA-2vzbA:
undetectable		 5hqaA-2vzbA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ALA A  46
GLU A  54
VAL A  43
TYR A  36
PHE A  55
 None
MG  A1001 (-3.2A)
None
None
None
 1.43A 5vlmH-2vzbA:
2.0		 5vlmH-2vzbA:
23.15