SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN
(Streptomyces
clavuligerus) 		4 / 6 ALA B 248
SER B 219
ARG B 202
LEU B 244
 None
 1.11A 1gahA-2vzkB:
undetectable		 1gahA-2vzkB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN
(Streptomyces
clavuligerus) 		5 / 11 ASN B 302
ILE B 364
VAL B 292
LEU B 355
ILE B 266
 None
 1.15A 2h42A-2vzkB:
undetectable		 2h42A-2vzkB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN
(Streptomyces
clavuligerus) 		5 / 10 GLY B 311
ASP B 316
SER B 314
ALA B 273
ILE B 364
 None
 1.15A 4xj7C-2vzkB:
undetectable
4xj7D-2vzkB:
undetectable		 4xj7C-2vzkB:
25.68
4xj7D-2vzkB:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN
(Streptomyces
clavuligerus) 		5 / 12 PHE B 328
ILE B 326
ALA B 279
VAL B 268
ILE B 364
 None
 1.39A 5mlmA-2vzkB:
undetectable		 5mlmA-2vzkB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN
(Streptomyces
clavuligerus) 		5 / 12 LEU B 226
ASP B 198
LEU B 200
ALA B 237
GLY B 233
 None
 1.10A 6b0iB-2vzkB:
undetectable		 6b0iB-2vzkB:
19.25