SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 GLN A   7
ASP A 123
VAL A  31
GLY A  29
 CA  A1128 (-3.2A)
CA  A1128 (-3.2A)
None
CA  A1128 (-4.4A)
 1.22A 1ekjC-2vzpA:
undetectable
1ekjD-2vzpA:
undetectable		 1ekjC-2vzpA:
21.83
1ekjD-2vzpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 ASP A 123
VAL A  31
GLY A  29
GLN A   7
 CA  A1128 (-3.2A)
None
CA  A1128 (-4.4A)
CA  A1128 (-3.2A)
 1.18A 1ekjC-2vzpA:
undetectable
1ekjD-2vzpA:
undetectable		 1ekjC-2vzpA:
21.83
1ekjD-2vzpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 GLY A  27
GLU A   9
ALA A   8
ASP A   5
 CA  A1128 ( 4.3A)
CA  A1128 (-2.2A)
None
None
 0.92A 5mvsA-2vzpA:
undetectable		 5mvsA-2vzpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 GLY A  27
GLU A   9
ALA A   8
ASP A   5
 CA  A1128 ( 4.3A)
CA  A1128 (-2.2A)
None
None
 0.90A 5mvsB-2vzpA:
undetectable		 5mvsB-2vzpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 ASN A  21
HIS A  22
GLY A 119
ASN A 121
 None
None
None
EDO  A1130 (-3.4A)
 1.03A 5x7pA-2vzpA:
8.7		 5x7pA-2vzpA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 ASN A  21
HIS A  22
TRP A  90
ASN A 121
 None
None
None
EDO  A1130 (-3.4A)
 0.33A 5x7pA-2vzpA:
8.7		 5x7pA-2vzpA:
6.98