SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  76
GLU A  99
LEU A 154
LEU A 170
GLY A  82
 None
None
None
None
HEM  A1206 (-4.0A)
 1.27A 1d4fA-2vzwA:
undetectable		 1d4fA-2vzwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  76
GLU A  99
LEU A 154
LEU A 170
GLY A  82
 None
None
None
None
HEM  A1206 (-4.0A)
 1.20A 1d4fD-2vzwA:
undetectable		 1d4fD-2vzwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 203
ALA A 189
ALA A 191
VAL A  86
LEU A  66
 None
 1.28A 1hbpA-2vzwA:
undetectable		 1hbpA-2vzwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 203
ALA A 189
ALA A 191
VAL A  86
LEU A  66
 None
 1.23A 1rbpA-2vzwA:
undetectable		 1rbpA-2vzwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 183
VAL A  77
PRO A 178
THR A 152
 None
 1.34A 2q6oB-2vzwA:
undetectable		 2q6oB-2vzwA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 112
PRO A 113
LEU A  93
 ACT  A1207 ( 4.6A)
HEM  A1206 ( 3.7A)
ACT  A1207 (-3.3A)
 0.44A 2qd5B-2vzwA:
undetectable		 2qd5B-2vzwA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 130
GLY A 155
GLU A 184
SER A 140
 None
None
None
HEM  A1206 (-4.6A)
 0.84A 2xctS-2vzwA:
undetectable
2xctU-2vzwA:
undetectable		 2xctS-2vzwA:
14.16
2xctU-2vzwA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  97
VAL A  70
ILE A  69
LEU A 203
LEU A  62
 None
 1.23A 4jtqA-2vzwA:
undetectable		 4jtqA-2vzwA:
20.00