SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.21A 1u18A-2vzxA:
undetectable		 1u18A-2vzxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 12 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  64 ( 3.6A)
CR8  A  64 ( 4.3A)
None
None
None
 0.86A 2jfaB-2vzxA:
undetectable		 2jfaB-2vzxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		3 / 3 HIS A 212
GLU A 211
HIS A 193
 None
CR8  A  64 ( 3.6A)
CR8  A  64 ( 3.5A)
 0.76A 3ba0A-2vzxA:
undetectable		 3ba0A-2vzxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 4 VAL A 118
PHE A 115
PHE A 114
VAL A  67
 None
 1.26A 3rv5C-2vzxA:
undetectable
3rv5D-2vzxA:
undetectable		 3rv5C-2vzxA:
17.57
3rv5D-2vzxA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 7 LEU A 162
GLU A 140
LEU A 137
GLU A 196
 None
 0.93A 3s56B-2vzxA:
undetectable		 3s56B-2vzxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 5 LYS A  65
ILE A 195
VAL A 191
LEU A 146
 CR8  A  64 ( 3.6A)
CR8  A  64 ( 3.6A)
None
None
 1.11A 3wzdA-2vzxA:
undetectable		 3wzdA-2vzxA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 10 TYR A 177
ARG A  91
VAL A  67
TYR A  71
ILE A 195
 None
CR8  A  64 ( 3.0A)
None
None
CR8  A  64 ( 3.6A)
 1.36A 5hw8C-2vzxA:
undetectable
5hw8H-2vzxA:
undetectable		 5hw8C-2vzxA:
18.22
5hw8H-2vzxA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 8 THR A 176
TYR A 177
ARG A 104
TRP A  89
 None
None
None
CR8  A  64 ( 3.8A)
 1.08A 5tzoA-2vzxA:
undetectable		 5tzoA-2vzxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 12 THR A  58
MET A 159
PHE A 173
ILE A 157
THR A 175
 None
CR8  A  64 ( 3.4A)
None
CR8  A  64 ( 4.8A)
None
 1.25A 5w8aA-2vzxA:
undetectable		 5w8aA-2vzxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 6 PHE A 125
PRO A 126
GLY A 129
ASN A 128
 None
 0.90A 5x24A-2vzxA:
undetectable		 5x24A-2vzxA:
18.20