SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 MET A 518
GLN A 519
ARG A 450
MET A 539
 None
 1.17A 1dtlA-2w01A:
undetectable		 1dtlA-2w01A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ILE A 583
ILE A 585
THR A 443
THR A 545
 None
 0.90A 1sbrA-2w01A:
3.4		 1sbrA-2w01A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ILE A 583
ILE A 585
THR A 443
THR A 545
 None
 0.91A 1sbrB-2w01A:
3.9		 1sbrB-2w01A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		6 / 12 LEU A 509
ILE A 541
GLY A 515
ILE A 585
VAL A 622
GLY A 542
 None
 1.42A 3bwcB-2w01A:
undetectable		 3bwcB-2w01A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		5 / 8 ILE A 541
LEU A 630
THR A 571
VAL A 619
GLY A 515
 None
 1.33A 3dcjB-2w01A:
undetectable		 3dcjB-2w01A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 GLY A 515
GLN A 519
MET A 475
ILE A 479
VAL A 496
 None
 1.39A 3fhjC-2w01A:
undetectable		 3fhjC-2w01A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A 484
THR A 485
LEU A 497
ASP A 507
 None
 1.01A 3ps9A-2w01A:
undetectable		 3ps9A-2w01A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 LYS A 435
ARG A 439
VAL A 548
 None
 1.03A 4x3uA-2w01A:
undetectable
4x3uB-2w01A:
undetectable		 4x3uA-2w01A:
13.99
4x3uB-2w01A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 MET A 518
GLU A 575
GLY A 542
ILE A 574
ILE A 585
 None
 1.48A 4xucA-2w01A:
undetectable		 4xucA-2w01A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 MET A 518
GLU A 575
GLY A 542
ILE A 574
ILE A 585
 None
 1.49A 4xudA-2w01A:
undetectable		 4xudA-2w01A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A 515
GLN A 519
MET A 475
ILE A 479
VAL A 496
 None
 1.40A 5v0iA-2w01A:
undetectable		 5v0iA-2w01A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2w01 ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A 515
GLN A 519
MET A 475
ILE A 479
VAL A 496
 None
 1.35A 5v0iB-2w01A:
undetectable		 5v0iB-2w01A:
22.39