SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 7 ILE A 212
TYR A 236
PHE A 238
PHE A 255
 None
 1.05A 1e71M-2w0iA:
undetectable		 1e71M-2w0iA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 7 ILE A 212
TYR A 236
PHE A 238
PHE A 255
 None
 1.05A 1e72M-2w0iA:
undetectable		 1e72M-2w0iA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.13A 2y69C-2w0iA:
undetectable
2y69J-2w0iA:
undetectable		 2y69C-2w0iA:
19.83
2y69J-2w0iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.03A 3ablP-2w0iA:
undetectable
3ablW-2w0iA:
undetectable		 3ablP-2w0iA:
19.83
3ablW-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.14A 3abmC-2w0iA:
undetectable
3abmJ-2w0iA:
undetectable		 3abmC-2w0iA:
19.83
3abmJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.08A 3ag3C-2w0iA:
undetectable
3ag3J-2w0iA:
undetectable		 3ag3C-2w0iA:
19.83
3ag3J-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2w0i TWINFILIN-2
(Homo
sapiens) 		5 / 12 LEU A 182
ILE A 256
VAL A 283
LEU A 289
PHE A 287
 None
 1.13A 3w67B-2w0iA:
undetectable		 3w67B-2w0iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.01A 3wg7P-2w0iA:
undetectable
3wg7W-2w0iA:
undetectable		 3wg7P-2w0iA:
19.83
3wg7W-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 7 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 0.98A 3x2qP-2w0iA:
undetectable
3x2qW-2w0iA:
undetectable		 3x2qP-2w0iA:
19.83
3x2qW-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U3E_A_ACTA705_0
(RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 4 HIS A 313
ASP A 309
TYR A 241
VAL A 312
 None
 1.48A 4u3eA-2w0iA:
0.9		 4u3eA-2w0iA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.06A 5b1bC-2w0iA:
undetectable
5b1bJ-2w0iA:
undetectable		 5b1bC-2w0iA:
19.83
5b1bJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.06A 5wauC-2w0iA:
undetectable
5wauJ-2w0iA:
undetectable		 5wauC-2w0iA:
19.83
5wauJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.04A 5wauc-2w0iA:
undetectable
5wauj-2w0iA:
undetectable		 5wauc-2w0iA:
19.83
5wauj-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.08A 5xdqC-2w0iA:
undetectable
5xdqJ-2w0iA:
undetectable		 5xdqC-2w0iA:
19.83
5xdqJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 5 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.06A 5xdqP-2w0iA:
undetectable
5xdqW-2w0iA:
undetectable		 5xdqP-2w0iA:
19.83
5xdqW-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.02A 5z84P-2w0iA:
undetectable
5z84W-2w0iA:
undetectable		 5z84P-2w0iA:
19.83
5z84W-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.00A 5z85P-2w0iA:
undetectable
5z85W-2w0iA:
undetectable		 5z85P-2w0iA:
19.83
5z85W-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.04A 5z86C-2w0iA:
undetectable
5z86J-2w0iA:
undetectable		 5z86C-2w0iA:
19.83
5z86J-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.03A 5z86P-2w0iA:
undetectable
5z86W-2w0iA:
undetectable		 5z86P-2w0iA:
19.83
5z86W-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.06A 5zcoP-2w0iA:
undetectable
5zcoW-2w0iA:
undetectable		 5zcoP-2w0iA:
19.83
5zcoW-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.10A 5zcpC-2w0iA:
undetectable
5zcpJ-2w0iA:
undetectable		 5zcpC-2w0iA:
19.83
5zcpJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w0i TWINFILIN-2
(Homo
sapiens) 		4 / 6 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.04A 5zcpP-2w0iA:
undetectable
5zcpW-2w0iA:
undetectable		 5zcpP-2w0iA:
19.83
5zcpW-2w0iA:
20.33