SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 12 ALA A 134
LEU A 135
LEU A  91
ILE A  66
LEU A 150
 None
 0.99A 1errB-2w0mA:
undetectable		 1errB-2w0mA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 12 ASP A  13
ILE A  20
PRO A  21
ILE A  26
TYR A 162
 None
 0.77A 1kijB-2w0mA:
undetectable		 1kijB-2w0mA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 12 ILE A  20
PRO A  21
ILE A  26
TYR A 162
ARG A   4
 None
 0.99A 1kijB-2w0mA:
undetectable		 1kijB-2w0mA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 10 ILE A 187
PHE A  39
ILE A 202
ASP A  13
ILE A  16
 None
 1.20A 3o1cA-2w0mA:
undetectable		 3o1cA-2w0mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 10 ILE A 187
PHE A  39
ILE A 202
ASP A  13
ILE A  16
 None
 1.20A 3o1xA-2w0mA:
undetectable		 3o1xA-2w0mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 10 ILE A 187
PHE A  39
ILE A 202
ASP A  13
ILE A  16
 None
 1.26A 3qgzA-2w0mA:
undetectable		 3qgzA-2w0mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		4 / 8 ILE A 227
ASP A 220
ILE A 221
GLY A  33
 None
None
None
POP  A1240 (-3.3A)
 0.82A 4ac9C-2w0mA:
2.4		 4ac9C-2w0mA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		4 / 7 LEU A 127
ALA A 163
SER A  40
THR A 164
 None
 1.04A 4ikjA-2w0mA:
undetectable
4ikjB-2w0mA:
undetectable		 4ikjA-2w0mA:
21.84
4ikjB-2w0mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		3 / 3 SER A  40
ASP A 130
GLN A 166
 None
 0.81A 4oltA-2w0mA:
undetectable
4oltB-2w0mA:
undetectable		 4oltA-2w0mA:
20.62
4oltB-2w0mA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		3 / 3 GLN A 166
SER A  40
ASP A 130
 None
 0.81A 4qwpA-2w0mA:
1.1
4qwpB-2w0mA:
undetectable		 4qwpA-2w0mA:
20.23
4qwpB-2w0mA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		4 / 7 VAL A 110
ASN A 111
ILE A 114
VAL A 153
 None
 0.75A 5bmvC-2w0mA:
undetectable		 5bmvC-2w0mA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		3 / 3 PHE A  12
ILE A 202
ASP A 220
 None
 0.71A 5cswA-2w0mA:
undetectable		 5cswA-2w0mA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		4 / 7 ARG A  68
THR A  37
ILE A  38
LEU A  41
 None
POP  A1240 (-3.6A)
POP  A1240 (-4.1A)
None
 0.93A 5te8A-2w0mA:
undetectable		 5te8A-2w0mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		3 / 3 GLN A  17
ILE A 227
HIS A  42
 None
 0.68A 5z12B-2w0mA:
undetectable		 5z12B-2w0mA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		5 / 10 LEU A  15
GLY A   8
ILE A   9
ILE A 202
ILE A 187
 None
 1.13A 6ebpD-2w0mA:
undetectable		 6ebpD-2w0mA:
13.03