SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2w18 PARTNER AND
LOCALIZER OF BRCA2
(Homo
sapiens) 		4 / 5 ALA A1130
TRP A1140
LEU A1142
ALA A1129
 None
 1.23A 2jstA-2w18A:
undetectable
2jstB-2w18A:
undetectable		 2jstA-2w18A:
11.54
2jstB-2w18A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2w18 PARTNER AND
LOCALIZER OF BRCA2
(Homo
sapiens) 		5 / 12 VAL A 928
ASN A 930
LEU A 961
PHE A 994
GLY A 999
 None
 1.17A 4pevC-2w18A:
undetectable		 4pevC-2w18A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2w18 PARTNER AND
LOCALIZER OF BRCA2
(Homo
sapiens) 		4 / 5 VAL A 991
PHE A 876
MET A 875
GLY A1166
 None
 1.35A 6hd4A-2w18A:
undetectable		 6hd4A-2w18A:
19.91