SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 8 SER A  56
LEU A 112
GLU A 113
LEU A  51
 None
 0.82A 1eupA-2w1jA:
undetectable		 1eupA-2w1jA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		3 / 3 GLN A 106
ILE A  22
HIS A  84
 None
 0.75A 1k74A-2w1jA:
undetectable		 1k74A-2w1jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 203
ALA A 130
LEU A  94
VAL A  85
LEU A 146
 None
 1.26A 1s9pB-2w1jA:
undetectable		 1s9pB-2w1jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 117
PRO A 118
ARG A  40
 None
 0.36A 2qd4B-2w1jA:
undetectable		 2qd4B-2w1jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 11 ASP A 178
LEU A 204
THR A 189
VAL A 182
TYR A 187
 None
 1.49A 3mbhA-2w1jA:
undetectable		 3mbhA-2w1jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 178
LEU A 204
THR A 189
VAL A 182
TYR A 187
 None
 1.47A 3mbhB-2w1jA:
undetectable		 3mbhB-2w1jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 178
LEU A 204
THR A 189
VAL A 182
TYR A 187
 None
 1.47A 3mbhC-2w1jA:
undetectable		 3mbhC-2w1jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 178
LEU A 204
THR A 189
VAL A 182
TYR A 187
 None
 1.48A 3mbhD-2w1jA:
undetectable		 3mbhD-2w1jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 7 ASN A 156
VAL A 188
TYR A 163
ARG A 209
 None
 1.07A 4ijiH-2w1jA:
undetectable		 4ijiH-2w1jA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 7 LEU A 179
THR A 129
LEU A 191
THR A 100
THR A 115
 None
 1.30A 4z90A-2w1jA:
undetectable
4z90B-2w1jA:
undetectable
4z90C-2w1jA:
undetectable
4z90D-2w1jA:
undetectable
4z90E-2w1jA:
undetectable		 4z90A-2w1jA:
20.25
4z90B-2w1jA:
20.25
4z90C-2w1jA:
20.25
4z90D-2w1jA:
20.25
4z90E-2w1jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 11 GLN A 106
ALA A  70
GLY A  99
THR A 100
ALA A 101
 None
 1.32A 5bxnV-2w1jA:
undetectable
5bxnW-2w1jA:
undetectable		 5bxnV-2w1jA:
22.18
5bxnW-2w1jA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 11 GLN A 106
ALA A  98
GLY A  99
THR A 100
ALA A 101
 None
 1.25A 5bxnV-2w1jA:
undetectable
5bxnW-2w1jA:
undetectable		 5bxnV-2w1jA:
22.18
5bxnW-2w1jA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 114
THR A 115
SER A  56
VAL A  55
 None
 0.88A 5ewuA-2w1jA:
undetectable		 5ewuA-2w1jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 114
THR A 115
SER A  56
VAL A  55
 None
 1.00A 5ewuB-2w1jA:
undetectable		 5ewuB-2w1jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 8 SER A  56
THR A 115
THR A 129
THR A 100
 None
 1.01A 5l4eA-2w1jA:
undetectable
5l4eB-2w1jA:
undetectable
5l4eC-2w1jA:
undetectable
5l4eD-2w1jA:
undetectable
5l4eE-2w1jA:
undetectable		 5l4eA-2w1jA:
22.46
5l4eB-2w1jA:
22.46
5l4eC-2w1jA:
22.46
5l4eD-2w1jA:
22.46
5l4eE-2w1jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  22
LEU A 105
ILE A 128
LEU A 190
ILE A  87
 None
 0.93A 5mugA-2w1jA:
undetectable		 5mugA-2w1jA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		3 / 3 GLN A 106
ILE A  22
HIS A  84
 None
 0.69A 5z12B-2w1jA:
undetectable		 5z12B-2w1jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 4 LEU A 191
ASP A  58
PRO A  59
ARG A 202
 None
 1.11A 6fgdA-2w1jA:
undetectable		 6fgdA-2w1jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 6 THR A 144
LEU A 146
THR A 132
LEU A 204
 GOL  A1216 (-4.3A)
None
None
None
 1.14A 6mvxA-2w1jA:
undetectable
6mvxB-2w1jA:
undetectable
6mvxC-2w1jA:
undetectable		 6mvxA-2w1jA:
19.31
6mvxB-2w1jA:
19.31
6mvxC-2w1jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2w1j PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 154
ASP A 150
PHE A 152
PHE A 140
ILE A  90
 None
 1.17A 6mxtA-2w1jA:
undetectable		 6mxtA-2w1jA:
18.61