SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 5 HIS A 116
GLU A  79
ALA A 113
HIS A 144
 None
 1.38A 1errA-2w1kA:
undetectable
1errB-2w1kA:
undetectable		 1errA-2w1kA:
21.28
1errB-2w1kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A  98
ILE A 141
SER A 139
ARG A 138
 None
 0.89A 2byoA-2w1kA:
undetectable		 2byoA-2w1kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 113
LEU A 122
VAL A  83
LEU A 111
GLY A  80
 None
 1.12A 2f8lA-2w1kA:
undetectable		 2f8lA-2w1kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 5 PRO A 131
ILE A 137
ARG A 222
ASP A 133
 None
None
MES  A1243 (-2.7A)
MES  A1243 (-3.3A)
 1.48A 2rhmD-2w1kA:
undetectable		 2rhmD-2w1kA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 176
VAL A 109
ILE A 105
ARG A 215
 None
 0.85A 3mssB-2w1kA:
undetectable		 3mssB-2w1kA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 132
SER A  59
TYR A 167
HIS A 124
 MES  A1243 (-3.6A)
None
None
None
 1.37A 4arcA-2w1kA:
undetectable		 4arcA-2w1kA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 167
SER A 139
TYR A  62
HIS A 124
 None
 1.34A 4arcA-2w1kA:
undetectable		 4arcA-2w1kA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 112
TYR A 110
ILE A 141
ASP A 114
ALA A 113
 None
 1.14A 5kvaA-2w1kA:
undetectable		 5kvaA-2w1kA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 112
TYR A 110
ILE A 141
ASP A 114
ALA A 113
 None
 1.16A 5kvaB-2w1kA:
undetectable		 5kvaB-2w1kA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2w1k PUTATIVE SORTASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 134
THR A 135
ASN A 199
LYS A 198
 None
 1.05A 5xxiA-2w1kA:
undetectable		 5xxiA-2w1kA:
20.22