SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 GLY A 945
TRP A 934
VAL A 917
ALA A 982
 None
 0.96A 1p6kA-2w1nA:
undetectable		 1p6kA-2w1nA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 5 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.11A 1rs7A-2w1nA:
undetectable		 1rs7A-2w1nA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 7 VAL A 865
VAL A 797
LEU A 781
SER A 780
 None
 0.79A 3hs6B-2w1nA:
undetectable		 3hs6B-2w1nA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 8 ASN A 929
THR A 966
ALA A 922
SER A 923
 None
 0.92A 3kp6A-2w1nA:
undetectable		 3kp6A-2w1nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 5 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.07A 4d33A-2w1nA:
undetectable		 4d33A-2w1nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 5 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.10A 4d33B-2w1nA:
undetectable		 4d33B-2w1nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2w1n O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.07A 4d39B-2w1nA:
undetectable		 4d39B-2w1nA:
18.91