SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		5 / 12 LEU A  85
GLY A 220
ALA A 221
GLY A 171
LEU A 174
 None
 1.03A 1fe2A-2w1pA:
undetectable		 1fe2A-2w1pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		5 / 12 LEU A  85
GLY A 220
ALA A 221
GLY A 171
LEU A 174
 None
 1.10A 1igxA-2w1pA:
0.1		 1igxA-2w1pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		4 / 8 PHE A  58
PHE A  63
SER A 228
ALA A 144
 None
 0.99A 1rqpC-2w1pA:
undetectable		 1rqpC-2w1pA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 5 ALA A 122
TRP A 260
LEU A 184
ALA A 118
 None
 1.28A 2jstA-2w1pA:
undetectable
2jstB-2w1pA:
undetectable		 2jstA-2w1pA:
12.03
2jstB-2w1pA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 7 PHE A  56
ALA A 144
ALA A 148
THR A 152
 None
 0.65A 2wx2A-2w1pA:
undetectable		 2wx2A-2w1pA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 8 PHE A  56
ALA A 144
ALA A 148
THR A 152
 None
 0.74A 2wx2B-2w1pA:
undetectable		 2wx2B-2w1pA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 ILE A 204
GLY A  95
GLY A  93
ALA A 207
VAL A  98
 None
 1.17A 2yvlD-2w1pA:
undetectable		 2yvlD-2w1pA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 SER A  38
ASN A  43
ARG A 129
GLY A 108
ILE A 102
 BOG  A1277 (-4.7A)
None
None
None
None
 1.34A 3a25A-2w1pA:
undetectable		 3a25A-2w1pA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 8 PHE A  56
ALA A 144
ALA A 148
THR A 152
 None
 0.57A 3khmA-2w1pA:
undetectable		 3khmA-2w1pA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		3 / 3 ASN A 224
ASN A 160
GLU A 175
 None
 0.89A 3kpdB-2w1pA:
undetectable		 3kpdB-2w1pA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 8 PHE A  56
ALA A 144
ALA A 148
THR A 152
 None
 0.74A 3l4dA-2w1pA:
undetectable		 3l4dA-2w1pA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 8 PHE A  56
ALA A 144
ALA A 148
THR A 152
 None
 0.73A 3l4dD-2w1pA:
undetectable		 3l4dD-2w1pA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		3 / 3 VAL A 191
VAL A 186
TRP A 260
 None
 0.90A 3l8lA-2w1pA:
undetectable
3l8lB-2w1pA:
undetectable		 3l8lA-2w1pA:
5.70
3l8lB-2w1pA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 ILE A 204
GLY A  93
ILE A  88
ILE A  86
LEU A 213
 None
 0.98A 3mb5A-2w1pA:
undetectable		 3mb5A-2w1pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 8 PHE A  92
PHE A  63
ASN A 112
ALA A 226
 None
 1.00A 3t3sF-2w1pA:
undetectable		 3t3sF-2w1pA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 GLY A 163
GLY A 164
GLY A 165
SER A 167
ALA A 161
 None
None
None
BOG  A1275 (-2.6A)
None
 0.98A 4htfA-2w1pA:
undetectable		 4htfA-2w1pA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 GLY A 163
GLY A 164
GLY A 165
SER A 167
ALA A 161
 None
None
None
BOG  A1275 (-2.6A)
None
 0.98A 4htfB-2w1pA:
undetectable		 4htfB-2w1pA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 8 VAL A 115
LEU A 119
TYR A  31
THR A 197
 None
 0.80A 4ma7A-2w1pA:
undetectable		 4ma7A-2w1pA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		5 / 11 ILE A 131
PHE A 128
VAL A 120
THR A 116
GLU A  51
 None
 1.15A 5lg3A-2w1pA:
undetectable		 5lg3A-2w1pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		5 / 9 ILE A 131
PHE A 128
VAL A 120
THR A 116
GLU A  51
 None
 1.14A 5lg3D-2w1pA:
1.2		 5lg3D-2w1pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2w1p
AQUAPORIN PIP2-7 7
(Komagataella
pastoris) 		4 / 9 ILE A 131
PHE A 128
VAL A 120
THR A 116
 None
 1.06A 5lg3I-2w1pA:
undetectable		 5lg3I-2w1pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 ILE A  88
PHE A  94
SER A  89
ILE A  68
ALA A  69
 None
 1.16A 5n0sB-2w1pA:
undetectable		 5n0sB-2w1pA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2w1p AQUAPORIN PIP2-7
7

(Komagataella
pastoris) 		5 / 12 PHE A  94
VAL A  96
SER A  89
ILE A  68
ALA A  69
 None
 1.06A 5n0sB-2w1pA:
undetectable		 5n0sB-2w1pA:
20.14