SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 GLY A 120
ILE A  47
LEU A  79
ALA A 111
VAL A 110
 None
 1.09A 1jg2A-2w1vA:
2.3		 1jg2A-2w1vA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 GLY A 121
GLY A 120
VAL A 110
LEU A 107
LEU A 118
 None
 1.03A 1mx1F-2w1vA:
undetectable		 1mx1F-2w1vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 GLY A 258
GLN A  48
LEU A  46
CYH A 191
PHE A 217
 None
 1.30A 1p93B-2w1vA:
undetectable		 1p93B-2w1vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 ALA A 242
LEU A 210
VAL A 239
HIS A 148
ILE A 190
 None
 1.13A 1s9pA-2w1vA:
undetectable		 1s9pA-2w1vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 ALA A 242
LEU A 210
VAL A 239
HIS A 148
ILE A 190
 None
 1.14A 1s9pD-2w1vA:
undetectable		 1s9pD-2w1vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 ILE A  47
ALA A 244
GLN A  50
PRO A  86
ARG A  61
 None
 1.49A 1u70A-2w1vA:
undetectable		 1u70A-2w1vA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		3 / 3 SER A  78
GLU A  81
ASP A 193
 None
 0.84A 2avdB-2w1vA:
undetectable		 2avdB-2w1vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 9 GLY A 189
PRO A 214
GLY A 173
CYH A  82
PHE A  83
 None
 1.18A 3ko0H-2w1vA:
undetectable
3ko0I-2w1vA:
undetectable		 3ko0H-2w1vA:
18.91
3ko0I-2w1vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 7 GLY A 173
CYH A  82
PHE A  83
GLY A 189
 None
 1.00A 3ko0M-2w1vA:
undetectable
3ko0P-2w1vA:
undetectable		 3ko0M-2w1vA:
18.91
3ko0P-2w1vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 8 GLY A 173
CYH A  82
PHE A  83
GLY A 189
 None
 0.99A 3ko0O-2w1vA:
undetectable
3ko0Q-2w1vA:
undetectable		 3ko0O-2w1vA:
18.91
3ko0Q-2w1vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 7 GLY A 189
GLY A 173
CYH A  82
PHE A  83
 None
 0.86A 3ko0M-2w1vA:
undetectable
3ko0P-2w1vA:
undetectable		 3ko0M-2w1vA:
18.91
3ko0P-2w1vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 SER A 177
SER A 175
THR A 134
TYR A 132
ASP A 174
 None
 1.14A 3mbhC-2w1vA:
3.8		 3mbhC-2w1vA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 SER A 177
SER A 175
THR A 134
TYR A 132
ASP A 174
 None
 1.16A 3mbhD-2w1vA:
3.7		 3mbhD-2w1vA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 SER A 177
SER A 175
THR A 134
TYR A 132
ASP A 174
 None
 1.17A 3mbhE-2w1vA:
3.0		 3mbhE-2w1vA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 5 THR A 134
ILE A 123
GLU A  97
PHE A 138
 None
 1.22A 4ac9C-2w1vA:
2.3		 4ac9C-2w1vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 5 THR A 134
ILE A 123
GLU A  97
PHE A 138
 None
 1.18A 4acaC-2w1vA:
2.2		 4acaC-2w1vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 5 THR A 134
ILE A 123
GLU A  97
PHE A 138
 None
 1.17A 4acbC-2w1vA:
2.0		 4acbC-2w1vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 7 TYR A 183
ILE A  76
TYR A 117
PRO A 182
 None
 1.00A 4g5jA-2w1vA:
undetectable		 4g5jA-2w1vA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		3 / 3 SER A 260
ALA A 242
VAL A 241
 None
 0.63A 4o2bA-2w1vA:
undetectable		 4o2bA-2w1vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		3 / 3 SER A 260
ALA A 242
VAL A 241
 None
 0.63A 4o2bC-2w1vA:
undetectable		 4o2bC-2w1vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 11 GLY A 121
TYR A 203
TYR A 213
ALA A 244
SER A  78
 None
 1.46A 4rv6B-2w1vA:
undetectable		 4rv6B-2w1vA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		3 / 3 SER A 260
ALA A 242
VAL A 241
 None
 0.48A 4x20C-2w1vA:
undetectable		 4x20C-2w1vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 GLU A  81
TYR A 213
TYR A 192
ILE A 119
ALA A 244
 None
 1.13A 5kvaA-2w1vA:
undetectable		 5kvaA-2w1vA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 12 GLU A  81
TYR A 213
TYR A 192
ILE A 119
ALA A 244
 None
 1.14A 5kvaB-2w1vA:
undetectable		 5kvaB-2w1vA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA302_0
(AMIDASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		5 / 9 GLU A  81
TYR A  87
LYS A 150
GLU A 166
TYR A 192
 None
 0.77A 5ny7A-2w1vA:
33.2		 5ny7A-2w1vA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2w1v NITRILASE HOMOLOG 2
(Mus
musculus) 		4 / 8 LEU A 299
LEU A 199
ALA A 200
LEU A 211
 None
 0.87A 5y7pC-2w1vA:
undetectable		 5y7pC-2w1vA:
24.26