SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 10 GLY A 443
LEU A 488
PHE A 471
THR A 475
LEU A 478
 None
 1.33A 1a8uA-2w1zA:
undetectable		 1a8uA-2w1zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 10 GLY A 443
LEU A 488
PHE A 471
THR A 475
LEU A 478
 None
 1.35A 1a8uB-2w1zA:
undetectable		 1a8uB-2w1zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ALA A 534
LEU A 532
LEU A 543
ILE A 483
LEU A 476
 None
 1.11A 1errA-2w1zA:
undetectable		 1errA-2w1zA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.75A 1fm9A-2w1zA:
undetectable		 1fm9A-2w1zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.74A 1k74A-2w1zA:
undetectable		 1k74A-2w1zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 11 LEU A 389
THR A 390
ILE A 209
THR A 212
VAL A 370
 None
 1.06A 1pkvA-2w1zA:
undetectable
1pkvB-2w1zA:
undetectable		 1pkvA-2w1zA:
11.48
1pkvB-2w1zA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 TYR A 540
ILE A 394
LEU A 516
VAL A 513
LEU A 547
 None
 1.20A 1r30A-2w1zA:
undetectable		 1r30A-2w1zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 TYR A 540
ILE A 394
LEU A 516
VAL A 513
LEU A 547
 None
 1.20A 1r30B-2w1zA:
undetectable		 1r30B-2w1zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 8 GLU A 429
ARG A 260
HIS A 282
ASP A 409
 None
 1.09A 1s3zA-2w1zA:
undetectable
1s3zB-2w1zA:
undetectable		 1s3zA-2w1zA:
17.39
1s3zB-2w1zA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.73A 1xlsA-2w1zA:
undetectable		 1xlsA-2w1zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.73A 1xlsB-2w1zA:
undetectable		 1xlsB-2w1zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.73A 1xlsC-2w1zA:
undetectable		 1xlsC-2w1zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.73A 1xlsD-2w1zA:
undetectable		 1xlsD-2w1zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.74A 2aclG-2w1zA:
undetectable		 2aclG-2w1zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ALA A 534
LEU A 532
LEU A 543
ILE A 483
LEU A 476
 None
 1.05A 2qxsA-2w1zA:
undetectable		 2qxsA-2w1zA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ALA A 534
LEU A 532
LEU A 543
ILE A 483
LEU A 476
 None
 1.13A 2qxsB-2w1zA:
undetectable		 2qxsB-2w1zA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 6 PHE A 325
LEU A 405
LEU A 321
ALA A 317
 None
 0.94A 2vcvB-2w1zA:
undetectable		 2vcvB-2w1zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 6 PHE A 325
LEU A 405
LEU A 321
ALA A 317
 None
 0.88A 2vcvK-2w1zA:
undetectable		 2vcvK-2w1zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 8 PHE A 325
LEU A 405
LEU A 321
ALA A 317
 None
 0.82A 2vcvP-2w1zA:
undetectable		 2vcvP-2w1zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 6 GLN A 533
PHE A 520
LEU A 476
PHE A 410
 None
 1.13A 3ablP-2w1zA:
2.8
3ablW-2w1zA:
undetectable		 3ablP-2w1zA:
21.68
3ablW-2w1zA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 8 ILE A 480
LEU A 517
PHE A 520
ARG A 395
LEU A 543
 None
 1.12A 3abmN-2w1zA:
undetectable
3abmW-2w1zA:
undetectable		 3abmN-2w1zA:
20.08
3abmW-2w1zA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2w1z ROP2
(Toxoplasma
gondii) 		3 / 3 ARG A 340
ARG A 336
TRP A 349
 SO4  A1557 ( 4.5A)
SO4  A1557 (-2.9A)
None
 1.33A 4cpzC-2w1zA:
undetectable		 4cpzC-2w1zA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.79A 4k6iA-2w1zA:
undetectable		 4k6iA-2w1zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 5 PHE A 323
HIS A 407
PHE A 325
PRO A 441
 None
 1.45A 4o8zA-2w1zA:
undetectable		 4o8zA-2w1zA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 6 ILE A 480
LEU A 517
PHE A 520
ARG A 395
 None
 1.01A 5b1aN-2w1zA:
undetectable
5b1aW-2w1zA:
undetectable		 5b1aN-2w1zA:
20.08
5b1aW-2w1zA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 LEU A 364
LEU A 547
PRO A 510
TRP A 484
ILE A 509
 None
 1.44A 5dlvB-2w1zA:
undetectable		 5dlvB-2w1zA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 LEU A 321
PHE A 323
HIS A 407
LEU A 431
GLY A 404
 None
 1.48A 5i8fA-2w1zA:
undetectable		 5i8fA-2w1zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2w1z ROP2
(Toxoplasma
gondii) 		3 / 3 ASP A 262
ASN A 414
PHE A 354
 None
 0.89A 5jglB-2w1zA:
undetectable		 5jglB-2w1zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2w1z ROP2
(Toxoplasma
gondii) 		4 / 7 GLN A 388
LEU A 391
ALA A 397
LEU A 400
 None
 1.10A 5nwvA-2w1zA:
undetectable		 5nwvA-2w1zA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w1z ROP2
(Toxoplasma
gondii) 		5 / 12 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.82A 5z12B-2w1zA:
undetectable		 5z12B-2w1zA:
11.48