SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.58A 1a4gA-2w20A:
25.1		 1a4gA-2w20A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.45A 1a4gB-2w20A:
24.8		 1a4gB-2w20A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 9 ILE A 376
GLY A 377
ASN A 398
LEU A 368
TYR A 346
 None
 1.08A 1dgmA-2w20A:
undetectable		 1dgmA-2w20A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ASP A 372
ILE A 442
GLU A 647
ARG A 663
TYR A 752
 None
 0.81A 1l7fA-2w20A:
21.5		 1l7fA-2w20A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.60A 1nncA-2w20A:
21.5		 1nncA-2w20A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 11 PHE A 430
PHE A 565
LEU A 566
VAL A 558
VAL A 589
 None
 1.29A 1q23J-2w20A:
undetectable		 1q23J-2w20A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 SER A 754
LEU A 755
ILE A 701
THR A 649
 None
 0.73A 1sbrA-2w20A:
undetectable		 1sbrA-2w20A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 LEU A 536
GLY A 613
ILE A 585
VAL A 558
ILE A 554
 None
 0.94A 1sdtA-2w20A:
undetectable		 1sdtA-2w20A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 ARG A 347
TYR A 590
GLU A 647
ARG A 663
ARG A 721
 None
 0.72A 1v3eB-2w20A:
26.1		 1v3eB-2w20A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 ARG A 347
TYR A 590
GLU A 647
ARG A 721
TYR A 752
 None
 0.79A 1v3eB-2w20A:
26.1		 1v3eB-2w20A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 LEU A 576
GLY A 677
SER A 674
ILE A 606
 None
 0.79A 1yajF-2w20A:
undetectable		 1yajF-2w20A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 9 GLY A 506
MET A 435
TYR A 535
ASP A 553
TYR A 453
 None
 1.35A 2a3aB-2w20A:
undetectable		 2a3aB-2w20A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 9 LEU A 536
GLY A 613
ILE A 585
VAL A 558
ILE A 554
 None
 0.94A 2avoA-2w20A:
undetectable		 2avoA-2w20A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 7 ARG A 334
GLY A 773
SER A 332
GLU A 331
 None
 1.07A 2c8aB-2w20A:
undetectable		 2c8aB-2w20A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 7 ARG A 334
GLY A 773
SER A 332
GLU A 331
 None
 1.02A 2c8aD-2w20A:
undetectable		 2c8aD-2w20A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.61A 2cmlA-2w20A:
5.1		 2cmlA-2w20A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.60A 2cmlB-2w20A:
21.7		 2cmlB-2w20A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.61A 2cmlC-2w20A:
21.8		 2cmlC-2w20A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.61A 2cmlD-2w20A:
21.6		 2cmlD-2w20A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
TYR A 590
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.40A 2f0zA-2w20A:
42.4		 2f0zA-2w20A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		8 / 12 ARG A 347
ILE A 348
ARG A 366
TYR A 590
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.56A 2f10A-2w20A:
41.8		 2f10A-2w20A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.68A 2htqA-2w20A:
22.3		 2htqA-2w20A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 9 LEU A 536
GLY A 613
ILE A 585
VAL A 558
ILE A 554
 None
 0.98A 2o4pB-2w20A:
undetectable		 2o4pB-2w20A:
11.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		11 / 12 ARG A 347
ILE A 348
ASP A 364
ILE A 416
ASP A 417
ASP A 434
TYR A 590
GLN A 602
ARG A 663
ARG A 721
TYR A 752
 None
 0.21A 2ya7A-2w20A:
68.2		 2ya7A-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 366
ASP A 417
PHE A 443
TYR A 590
GLN A 602
 None
 1.36A 2ya7A-2w20A:
68.2		 2ya7A-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 366
ILE A 348
ASP A 417
TYR A 590
GLN A 602
 None
 1.23A 2ya7A-2w20A:
68.2		 2ya7A-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		7 / 12 ASP A 364
ILE A 416
ASP A 417
ASP A 434
PHE A 443
TYR A 590
GLN A 602
 None
 0.70A 2ya7A-2w20A:
68.2		 2ya7A-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 6 ASP A 372
ILE A 442
LEU A 598
GLU A 647
TYR A 695
 None
 0.77A 2ya7A-2w20A:
68.2		 2ya7A-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		11 / 12 ARG A 347
ILE A 348
ASP A 364
ILE A 416
ASP A 417
ASP A 434
TYR A 590
GLN A 602
ARG A 663
ARG A 721
TYR A 752
 None
 0.24A 2ya7B-2w20A:
67.7		 2ya7B-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 366
ILE A 348
ASP A 417
PHE A 443
TYR A 590
GLN A 602
 None
 1.47A 2ya7B-2w20A:
67.7		 2ya7B-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		8 / 12 ILE A 348
ASP A 364
ILE A 416
ASP A 417
ASP A 434
PHE A 443
TYR A 590
GLN A 602
 None
 0.68A 2ya7B-2w20A:
67.7		 2ya7B-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 6 ASP A 372
ILE A 442
LEU A 598
GLU A 647
TYR A 695
 None
 0.72A 2ya7B-2w20A:
67.7		 2ya7B-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		11 / 12 ARG A 347
ILE A 348
ASP A 364
ILE A 416
ASP A 417
ASP A 434
TYR A 590
LEU A 598
ARG A 663
ARG A 721
TYR A 752
 None
 0.22A 2ya7C-2w20A:
68.0		 2ya7C-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 366
ASP A 417
PHE A 443
TYR A 590
LEU A 598
 None
 1.24A 2ya7C-2w20A:
68.0		 2ya7C-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 366
ILE A 348
ASP A 417
TYR A 590
LEU A 598
 None
 1.30A 2ya7C-2w20A:
68.0		 2ya7C-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		7 / 12 ASP A 364
ILE A 416
ASP A 417
ASP A 434
PHE A 443
TYR A 590
LEU A 598
 None
 0.72A 2ya7C-2w20A:
68.0		 2ya7C-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 6 ASP A 372
ILE A 442
GLN A 602
GLU A 647
TYR A 695
 None
 0.74A 2ya7C-2w20A:
68.0		 2ya7C-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		11 / 12 ARG A 347
ILE A 348
ASP A 364
ILE A 416
ASP A 417
ASP A 434
TYR A 590
GLN A 602
ARG A 663
ARG A 721
TYR A 752
 None
 0.24A 2ya7D-2w20A:
67.7		 2ya7D-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 366
ILE A 348
ASP A 417
PHE A 443
TYR A 590
GLN A 602
 None
 1.47A 2ya7D-2w20A:
67.7		 2ya7D-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		8 / 12 ILE A 348
ASP A 364
ILE A 416
ASP A 417
ASP A 434
PHE A 443
TYR A 590
GLN A 602
 None
 0.68A 2ya7D-2w20A:
67.7		 2ya7D-2w20A:
94.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 6 ASP A 372
ILE A 442
LEU A 598
GLU A 647
TYR A 695
 None
 0.74A 2ya7D-2w20A:
67.7		 2ya7D-2w20A:
94.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 4 ARG A 347
ASP A 364
LEU A 766
ARG A 663
 None
 1.33A 2ziaB-2w20A:
undetectable		 2ziaB-2w20A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.66A 3b7eA-2w20A:
21.8		 3b7eA-2w20A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.66A 3b7eB-2w20A:
10.3		 3b7eB-2w20A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.50A 3ckzA-2w20A:
10.5		 3ckzA-2w20A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 SER A 526
PHE A 520
ASP A 507
PRO A 403
 CL  A1792 (-3.1A)
None
None
None
 1.28A 3jqaA-2w20A:
undetectable		 3jqaA-2w20A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 SER A 526
PHE A 520
ASP A 507
PRO A 403
 CL  A1792 (-3.1A)
None
None
None
 1.23A 3jqaC-2w20A:
undetectable		 3jqaC-2w20A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 SER A 526
PHE A 520
ASP A 507
PRO A 403
 CL  A1792 (-3.1A)
None
None
None
 1.25A 3jqaD-2w20A:
undetectable		 3jqaD-2w20A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
 None
 0.63A 3k37B-2w20A:
24.9		 3k37B-2w20A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
TYR A 752
 None
 0.54A 3k39B-2w20A:
24.9		 3k39B-2w20A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 ASN A 623
ASN A 625
GLU A 620
 None
 0.92A 3kpdC-2w20A:
undetectable		 3kpdC-2w20A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.48A 3sanA-2w20A:
2.8		 3sanA-2w20A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.48A 3sanB-2w20A:
22.4		 3sanB-2w20A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 11 THR A 572
GLY A 571
PRO A 570
GLY A 362
ASP A 417
 None
 1.24A 3t8nD-2w20A:
0.2
3t8nF-2w20A:
undetectable		 3t8nD-2w20A:
15.27
3t8nF-2w20A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.62A 3ti5A-2w20A:
12.1		 3ti5A-2w20A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.65A 3ti5B-2w20A:
21.9		 3ti5B-2w20A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.59A 3ticA-2w20A:
21.6		 3ticA-2w20A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.62A 3ticB-2w20A:
21.6		 3ticB-2w20A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.59A 3ticC-2w20A:
8.2		 3ticC-2w20A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.59A 3ticD-2w20A:
21.8		 3ticD-2w20A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ASN A 599
ASP A 417
ILE A 348
ASP A 372
PHE A 565
 None
 1.48A 3wemA-2w20A:
2.5		 3wemA-2w20A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.66A 4b7nA-2w20A:
10.3		 4b7nA-2w20A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.74A 4b7qA-2w20A:
13.3		 4b7qA-2w20A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.71A 4b7qB-2w20A:
22.0		 4b7qB-2w20A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.66A 4b7qC-2w20A:
10.4		 4b7qC-2w20A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.72A 4b7qD-2w20A:
10.3		 4b7qD-2w20A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.63A 4cpnA-2w20A:
12.8		 4cpnA-2w20A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.62A 4cpnB-2w20A:
25.1		 4cpnB-2w20A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.45A 4cpzA-2w20A:
25.3		 4cpzA-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
LEU A 598
GLU A 647
ARG A 663
TYR A 752
 None
 0.81A 4cpzA-2w20A:
25.3		 4cpzA-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.43A 4cpzB-2w20A:
2.8		 4cpzB-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
LEU A 598
GLU A 647
ARG A 663
TYR A 752
 None
 0.79A 4cpzB-2w20A:
2.8		 4cpzB-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.66A 4cpzC-2w20A:
25.2		 4cpzC-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.39A 4cpzD-2w20A:
12.8		 4cpzD-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
LEU A 598
GLU A 647
ARG A 663
TYR A 752
 None
 0.81A 4cpzD-2w20A:
12.8		 4cpzD-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.69A 4cpzE-2w20A:
25.3		 4cpzE-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
LEU A 598
GLU A 647
ARG A 663
TYR A 752
 None
 0.74A 4cpzE-2w20A:
25.3		 4cpzE-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.65A 4cpzF-2w20A:
25.2		 4cpzF-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.59A 4cpzG-2w20A:
25.4		 4cpzG-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.67A 4cpzH-2w20A:
25.2		 4cpzH-2w20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 PHE A 661
VAL A 671
LEU A 653
TYR A 688
 None
 1.18A 4f5zA-2w20A:
undetectable		 4f5zA-2w20A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 ASP A 372
ASP A 364
GLU A 768
ASP A 434
 None
 1.04A 4feuD-2w20A:
undetectable		 4feuD-2w20A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 ASP A 372
ASP A 364
GLU A 768
ASP A 434
 None
 1.19A 4feuF-2w20A:
undetectable		 4feuF-2w20A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 7 ASP A 372
ASP A 364
GLU A 768
ASP A 434
 None
 1.21A 4fevF-2w20A:
undetectable		 4fevF-2w20A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 7 GLY A 567
VAL A 568
PHE A 436
ILE A 416
 None
 0.90A 4fglC-2w20A:
undetectable		 4fglC-2w20A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 ARG A 584
HIS A 581
TYR A 608
 None
 1.04A 4fu8A-2w20A:
undetectable		 4fu8A-2w20A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 ARG A 584
HIS A 581
TYR A 608
 None
 1.05A 4fu9A-2w20A:
undetectable		 4fu9A-2w20A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 ASP A 372
ASP A 364
GLU A 768
ASP A 434
 None
 1.20A 4gkhB-2w20A:
undetectable		 4gkhB-2w20A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 ASP A 372
ASP A 364
GLU A 768
ASP A 434
 None
 1.19A 4gkiC-2w20A:
undetectable		 4gkiC-2w20A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.60A 4i00A-2w20A:
5.9		 4i00A-2w20A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.51A 4mwrA-2w20A:
8.1		 4mwrA-2w20A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ASP A 372
ILE A 442
GLU A 647
ARG A 663
TYR A 752
 None
 0.82A 4mwvA-2w20A:
21.5		 4mwvA-2w20A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 721
TYR A 752
 None
 0.60A 4mwxA-2w20A:
6.1		 4mwxA-2w20A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 ARG A 347
ASP A 372
ARG A 721
 None
 0.53A 4mx0A-2w20A:
3.0		 4mx0A-2w20A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.79A 4wa5A-2w20A:
13.5		 4wa5A-2w20A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 LEU A 351
LEU A 755
ASN A 753
ILE A 765
 None
 0.92A 4ww7A-2w20A:
undetectable		 4ww7A-2w20A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 5 ILE A 463
ILE A 530
TYR A 465
GLU A 450
 None
None
MES  A1791 (-3.7A)
MES  A1791 ( 3.9A)
 1.28A 4zzcE-2w20A:
undetectable		 4zzcE-2w20A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 LYS A 455
ASP A 457
ILE A 463
 None
 0.84A 5kc4E-2w20A:
undetectable		 5kc4E-2w20A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 9 LEU A 536
GLY A 613
ILE A 585
VAL A 558
ILE A 554
 None
 1.01A 5kr2D-2w20A:
undetectable		 5kr2D-2w20A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		6 / 12 ARG A 347
ASP A 372
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.58A 5l17A-2w20A:
6.2		 5l17A-2w20A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 HIS A 769
SER A 780
LYS A 326
 None
 1.35A 5os7A-2w20A:
1.8		 5os7A-2w20A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 PHE A 436
ILE A 416
ASP A 375
GLY A 374
 None
 0.97A 5x5qE-2w20A:
undetectable		 5x5qE-2w20A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ASP A 364
ASP A 375
GLY A 441
ILE A 442
LEU A 368
 None
 0.76A 6dgxB-2w20A:
undetectable		 6dgxB-2w20A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 LEU A 359
PHE A 784
VAL A 726
THR A 572
LEU A 420
 None
 1.30A 6djzB-2w20A:
undetectable		 6djzB-2w20A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		7 / 12 ARG A 347
ILE A 348
ARG A 366
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.45A 6ekuA-2w20A:
40.3		 6ekuA-2w20A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		7 / 12 ARG A 347
ILE A 348
ASP A 417
GLU A 647
ARG A 663
ARG A 721
TYR A 752
 None
 0.72A 6ekuA-2w20A:
40.3		 6ekuA-2w20A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 HIS A 769
SER A 780
LYS A 326
 None
 1.35A 6gmdB-2w20A:
1.8		 6gmdB-2w20A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 2w20 SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 ARG A 347
ASP A 372
ARG A 663
ARG A 721
TYR A 752
 None
 0.64A 6hcxA-2w20A:
8.3		 6hcxA-2w20A:
9.34