SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 1.00A 1kglA-2w21A:
undetectable		 1kglA-2w21A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 MET A 214
LEU A 174
ILE A 194
PHE A 255
ILE A 233
 None
 1.06A 1xotA-2w21A:
undetectable		 1xotA-2w21A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 5 LEU A 124
LEU A 121
LEU A 115
MET A 101
 None
 0.98A 2oaxF-2w21A:
undetectable		 2oaxF-2w21A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 8 THR A 216
LEU A 167
ASP A 170
GLU A 135
 None
None
SO4  A1259 (-3.2A)
None
 0.95A 2zw9A-2w21A:
3.0		 2zw9A-2w21A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 TYR A  62
ILE A  53
GLY A  56
ALA A  55
LEU A  23
 None
SO4  A1262 (-3.6A)
None
None
None
 1.17A 3n8xA-2w21A:
undetectable		 3n8xA-2w21A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 8 ILE A  45
LEU A   7
VAL A 241
GLY A 240
 None
 0.88A 3w1wA-2w21A:
3.8		 3w1wA-2w21A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 LEU A 155
LEU A 121
ALA A 162
VAL A   8
ILE A 229
 None
 1.19A 4x1kD-2w21A:
undetectable		 4x1kD-2w21A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 11 LEU A 155
LEU A 121
ALA A 162
VAL A   8
ILE A 229
 None
 1.15A 4x20D-2w21A:
undetectable		 4x20D-2w21A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 ALA A  52
GLY A  51
GLY A  12
LEU A  11
LEU A  86
 SO4  A1262 (-3.7A)
SO4  A1262 (-3.1A)
SO4  A1259 (-3.5A)
None
None
 1.08A 5c0oE-2w21A:
undetectable		 5c0oE-2w21A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 8 GLU A  88
HIS A  97
GLY A  95
VAL A  98
 None
 0.78A 5f8yA-2w21A:
undetectable		 5f8yA-2w21A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 9 ILE A  45
THR A  49
TRP A  87
LEU A  31
LEU A  16
 None
 1.43A 5fhzB-2w21A:
5.8		 5fhzB-2w21A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		6 / 12 VAL A   9
LEU A 187
VAL A 251
GLY A 252
ALA A 234
LEU A 168
 None
 1.45A 5iktA-2w21A:
undetectable		 5iktA-2w21A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 8 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 0.92A 5ljbA-2w21A:
undetectable		 5ljbA-2w21A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 6 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 1.02A 5ljeA-2w21A:
undetectable		 5ljeA-2w21A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2w21 GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 GLY A  95
PHE A  91
HIS A  97
VAL A 129
 None
 1.08A 6hu9S-2w21A:
undetectable
6hu9q-2w21A:
undetectable		 6hu9S-2w21A:
13.03
6hu9q-2w21A:
22.27