SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 ALA A 503
LEU A 412
SER A 472
LEU A 475
LYS A 476
 None
 1.06A 2ceoB-2w2gA:
undetectable		 2ceoB-2w2gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A 487
THR A 398
GLU A 396
THR A 399
 None
 1.18A 2fb2B-2w2gA:
undetectable		 2fb2B-2w2gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 GLY A 609
THR A 612
CYH A 550
PHE A 581
 None
 1.05A 2qx4A-2w2gA:
undetectable
2qx4B-2w2gA:
undetectable		 2qx4A-2w2gA:
18.98
2qx4B-2w2gA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 CYH A 507
PHE A 511
ASP A 481
TYR A 483
 None
 1.37A 2todA-2w2gA:
1.1
2todB-2w2gA:
0.9		 2todA-2w2gA:
20.41
2todB-2w2gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 ASP A 481
TYR A 483
CYH A 507
PHE A 511
 None
 1.38A 2todA-2w2gA:
1.0
2todB-2w2gA:
0.5		 2todA-2w2gA:
20.41
2todB-2w2gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 CYH A 507
PHE A 511
ASP A 481
TYR A 483
 None
 1.40A 2todC-2w2gA:
0.5
2todD-2w2gA:
1.1		 2todC-2w2gA:
20.41
2todD-2w2gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 ASP A 481
TYR A 483
CYH A 507
PHE A 511
 None
 1.38A 2todC-2w2gA:
0.5
2todD-2w2gA:
1.1		 2todC-2w2gA:
20.41
2todD-2w2gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 552
SER A 585
TYR A 583
HIS A 613
 None
 1.21A 2v0gA-2w2gA:
undetectable		 2v0gA-2w2gA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 11 ALA A 503
LEU A 412
SER A 472
LEU A 475
LYS A 476
 None
 1.11A 2xn5A-2w2gA:
undetectable		 2xn5A-2w2gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 PRO A 548
GLU A 571
TYR A 583
 None
 0.77A 2zmbA-2w2gA:
undetectable		 2zmbA-2w2gA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 ALA A 493
GLY A 609
ILE A 592
ILE A 593
 None
 0.68A 4eatA-2w2gA:
2.3		 4eatA-2w2gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 11 ILE A 454
LEU A 437
ALA A 415
LEU A 412
LEU A 421
 None
 0.99A 4p65E-2w2gA:
undetectable
4p65F-2w2gA:
undetectable
4p65J-2w2gA:
undetectable
4p65L-2w2gA:
undetectable		 4p65E-2w2gA:
5.66
4p65F-2w2gA:
7.48
4p65J-2w2gA:
7.48
4p65L-2w2gA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 412
LEU A 421
ILE A 454
LEU A 437
ALA A 415
 None
 1.01A 4p65B-2w2gA:
undetectable
4p65D-2w2gA:
undetectable
4p65I-2w2gA:
undetectable
4p65J-2w2gA:
undetectable		 4p65B-2w2gA:
7.48
4p65D-2w2gA:
7.48
4p65I-2w2gA:
5.66
4p65J-2w2gA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 421
LEU A 412
ILE A 454
LEU A 437
ALA A 415
 None
 1.06A 4p65F-2w2gA:
undetectable
4p65H-2w2gA:
undetectable
4p65K-2w2gA:
undetectable
4p65L-2w2gA:
undetectable		 4p65F-2w2gA:
7.48
4p65H-2w2gA:
7.48
4p65K-2w2gA:
5.66
4p65L-2w2gA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 ASP A 424
THR A 486
TYR A 487
PRO A 488
 None
 1.37A 5b6iA-2w2gA:
undetectable		 5b6iA-2w2gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 9 SER A 626
ALA A 590
GLY A 491
GLY A 494
ALA A 493
 None
 0.96A 5d0xK-2w2gA:
undetectable
5d0xL-2w2gA:
undetectable		 5d0xK-2w2gA:
21.82
5d0xL-2w2gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 9 SER A 626
ALA A 590
GLY A 491
GLY A 494
ALA A 493
 None
 0.94A 5d0xY-2w2gA:
undetectable
5d0xZ-2w2gA:
undetectable		 5d0xY-2w2gA:
21.82
5d0xZ-2w2gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 LEU A 421
PHE A 414
LEU A 437
PHE A 436
 None
 1.25A 5iy5P-2w2gA:
undetectable
5iy5W-2w2gA:
undetectable		 5iy5P-2w2gA:
22.87
5iy5W-2w2gA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 504
LEU A 412
THR A 450
ILE A 459
ALA A 474
 None
 1.31A 5nm5B-2w2gA:
undetectable		 5nm5B-2w2gA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 LEU A 421
PHE A 414
LEU A 437
PHE A 436
 None
 1.22A 5xdxC-2w2gA:
undetectable
5xdxJ-2w2gA:
undetectable		 5xdxC-2w2gA:
22.53
5xdxJ-2w2gA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 LEU A 421
PHE A 414
LEU A 437
PHE A 436
 None
 1.25A 5xdxP-2w2gA:
undetectable
5xdxW-2w2gA:
undetectable		 5xdxP-2w2gA:
22.53
5xdxW-2w2gA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 504
LEU A 412
THR A 450
ILE A 459
ALA A 474
 None
 1.27A 5xiwD-2w2gA:
undetectable		 5xiwD-2w2gA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2w2g NON-STRUCTURAL
PROTEIN 3
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
 None
 1.45A 6bsiA-2w2gA:
undetectable		 6bsiA-2w2gA:
17.37