SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		5 / 12 PHE A 238
LEU A 239
LEU A 220
ALA A 224
LEU A 227
 None
 1.12A 1crbA-2w2iA:
undetectable		 1crbA-2w2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		5 / 12 ILE A  15
ALA A  40
GLN A 263
ILE A  49
PRO A  50
 None
 1.07A 1dhfA-2w2iA:
undetectable		 1dhfA-2w2iA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		5 / 12 GLU A 119
LEU A 251
GLY A 279
PHE A 280
ALA A 244
 None
 1.02A 1hvyD-2w2iA:
undetectable		 1hvyD-2w2iA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 6 ASN A 150
TRP A  54
HIS A 202
TYR A 200
 None
 1.34A 1mxdA-2w2iA:
undetectable		 1mxdA-2w2iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 7 ASN A 150
TRP A  54
HIS A 202
TYR A 200
 None
 1.35A 1mxgA-2w2iA:
undetectable		 1mxgA-2w2iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 6 TRP A 297
ASN A 291
LEU A 158
PHE A 316
 None
 1.11A 1ru9H-2w2iA:
undetectable
1ru9L-2w2iA:
undetectable		 1ru9H-2w2iA:
19.67
1ru9L-2w2iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		5 / 10 ALA A 287
TRP A 209
LEU A 201
GLY A 266
PHE A 268
 None
 1.38A 1ruaH-2w2iA:
undetectable
1ruaL-2w2iA:
undetectable		 1ruaH-2w2iA:
19.67
1ruaL-2w2iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 6 TRP A 297
ASN A 291
LEU A 158
PHE A 316
 None
 1.14A 1rukH-2w2iA:
undetectable
1rukL-2w2iA:
undetectable		 1rukH-2w2iA:
19.67
1rukL-2w2iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 5 PRO A 131
GLY A 283
ASN A 281
GLY A 180
 None
 1.08A 1zlqA-2w2iA:
undetectable		 1zlqA-2w2iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		5 / 12 GLU A 119
LEU A 251
GLY A 279
PHE A 280
ALA A 244
 None
 1.34A 2kceA-2w2iA:
undetectable		 2kceA-2w2iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		3 / 3 ASP A 117
ASN A 114
THR A 262
 None
 0.72A 2pymB-2w2iA:
undetectable		 2pymB-2w2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		3 / 3 ASP A 117
ASN A 114
THR A 262
 None
 0.81A 2q63B-2w2iA:
undetectable		 2q63B-2w2iA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 5 ILE A 169
MET A 318
LEU A 158
LEU A 161
 None
 1.07A 2zb7A-2w2iA:
undetectable		 2zb7A-2w2iA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 6 LEU A 151
ILE A 157
THR A 156
TRP A 297
 None
 1.34A 5ljeA-2w2iA:
undetectable		 5ljeA-2w2iA:
16.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		4 / 6 GLU A 221
ALA A 237
LEU A 239
TYR A 276
 None
 0.53A 5phhA-2w2iA:
42.6		 5phhA-2w2iA:
83.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2w2i 2-OXOGLUTARATE
OXYGENASE
(Homo
sapiens) 		6 / 12 VAL A  95
PHE A 179
ILE A  68
ILE A 137
LEU A 177
HIS A 202
 None
 1.33A 5uvmB-2w2iA:
undetectable		 5uvmB-2w2iA:
18.38