SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		3 / 3 TRP A 169
VAL A  93
TRP A 181
 None
 1.24A 1c4dA-2w2sA:
undetectable
1c4dB-2w2sA:
undetectable		 1c4dA-2w2sA:
6.15
1c4dB-2w2sA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		3 / 3 TRP A 181
VAL A  93
TRP A 169
 None
 1.14A 1c4dA-2w2sA:
undetectable
1c4dB-2w2sA:
undetectable		 1c4dA-2w2sA:
6.15
1c4dB-2w2sA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		4 / 4 GLY A  91
VAL A  93
TRP A 181
GLY A  98
 None
 1.15A 1ng8A-2w2sA:
undetectable		 1ng8A-2w2sA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		4 / 4 GLY A  91
VAL A  93
TRP A 181
GLY A  98
 None
 1.15A 1ng8B-2w2sA:
undetectable		 1ng8B-2w2sA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		4 / 8 LEU A 153
TYR A 138
PHE A  79
LEU A  76
 None
 0.92A 3i45A-2w2sA:
undetectable		 3i45A-2w2sA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		3 / 3 LEU A  31
TRP A  32
GLY A  66
 None
 0.74A 3l35A-2w2sA:
undetectable
3l35H-2w2sA:
undetectable		 3l35A-2w2sA:
13.37
3l35H-2w2sA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		3 / 3 LEU A  31
TRP A  32
GLY A  66
 None
 0.75A 3l35B-2w2sA:
undetectable
3l35K-2w2sA:
undetectable		 3l35B-2w2sA:
13.37
3l35K-2w2sA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		4 / 5 ILE A 155
LEU A 153
GLU A  58
VAL A 106
 None
 1.05A 4nkxB-2w2sA:
undetectable		 4nkxB-2w2sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		4 / 8 SER A  63
GLU A 147
ASP A 145
ASP A 146
 None
 1.41A 4qb9D-2w2sA:
undetectable		 4qb9D-2w2sA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		3 / 3 CYH A 178
MET A 173
ASN A 174
 None
 0.99A 5qh8A-2w2sA:
undetectable		 5qh8A-2w2sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		5 / 9 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.21A 6czmA-2w2sA:
undetectable
6czmB-2w2sA:
undetectable		 6czmA-2w2sA:
21.57
6czmB-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		5 / 9 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.21A 6czmB-2w2sA:
undetectable
6czmC-2w2sA:
undetectable		 6czmB-2w2sA:
21.57
6czmC-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		5 / 9 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.19A 6czmD-2w2sA:
undetectable
6czmE-2w2sA:
undetectable		 6czmD-2w2sA:
21.57
6czmE-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2w2s MATRIX PROTEIN
(Lagos
bat
lyssavirus) 		5 / 10 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.22A 6czmE-2w2sA:
undetectable
6czmF-2w2sA:
undetectable		 6czmE-2w2sA:
21.57
6czmF-2w2sA:
21.57