SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		5 / 12 THR A 210
ASP A  43
LEU A  44
LEU A 100
ILE A 132
 None
MG  A1224 (-2.5A)
None
None
None
 1.22A 1errA-2w35A:
undetectable		 1errA-2w35A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		4 / 8 LEU A 120
ILE A  27
ILE A 122
HIS A 125
 None
 0.94A 2azxA-2w35A:
undetectable		 2azxA-2w35A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		4 / 8 LEU A  44
LEU A  92
LYS A  95
ALA A  96
 None
 0.93A 2wekA-2w35A:
undetectable		 2wekA-2w35A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		4 / 5 THR A 134
GLY A 136
VAL A 181
PRO A 183
 None
 1.11A 4grkA-2w35A:
undetectable		 4grkA-2w35A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		3 / 3 ASP A 188
LEU A 114
VAL A 137
 None
 0.69A 4jecB-2w35A:
undetectable		 4jecB-2w35A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		5 / 12 PRO A  47
LEU A  53
GLY A 111
ASP A 110
THR A 217
 None
None
None
MG  A1224 (-3.2A)
None
 1.44A 4mubA-2w35A:
undetectable		 4mubA-2w35A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2w35 ENDONUCLEASE V
(Thermotoga
maritima) 		5 / 12 LEU A  85
GLY A  90
MET A 126
ILE A  81
PHE A  78
 None
 1.12A 4p6xE-2w35A:
undetectable		 4p6xE-2w35A:
21.11