SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 10 GLU A 211
ALA A 206
LEU A 217
ALA A 182
GLY A 185
 None
 1.31A 1mjqG-2w37A:
undetectable
1mjqH-2w37A:
undetectable		 1mjqG-2w37A:
18.24
1mjqH-2w37A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		4 / 6 ASP A 147
GLY A 181
ILE A 183
ILE A  30
 None
 0.90A 1n49D-2w37A:
undetectable		 1n49D-2w37A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		4 / 8 LYS A  37
THR A 180
SER A 326
GLU A 153
 None
 1.48A 1xr2B-2w37A:
0.5		 1xr2B-2w37A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		6 / 11 ILE A 183
ALA A 182
ALA A 206
ASN A 175
LEU A 178
ALA A 215
 None
 1.48A 2aclE-2w37A:
undetectable		 2aclE-2w37A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 9 SER A  95
SER A 118
GLY A 128
ILE A 110
PHE A 112
 None
 1.38A 2dr6A-2w37A:
0.0		 2dr6A-2w37A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 ASP A  75
ALA A  72
THR A  71
ALA A 332
HIS A 325
 None
 1.07A 2gluA-2w37A:
5.3		 2gluA-2w37A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		3 / 3 MET A 330
GLU A  18
ASN A 172
 None
 1.01A 3a27A-2w37A:
4.7		 3a27A-2w37A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 GLY A 109
LEU A  16
THR A 142
ILE A 327
PHE A  69
 None
 1.47A 3mneA-2w37A:
undetectable		 3mneA-2w37A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		4 / 5 LEU A 184
ASP A  31
GLU A  25
VAL A  15
 None
 1.33A 4nkvA-2w37A:
undetectable		 4nkvA-2w37A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 LEU A 163
GLY A 181
MET A 144
VAL A 173
ILE A  30
 None
 1.31A 4oktA-2w37A:
undetectable		 4oktA-2w37A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		4 / 4 THR A  63
GLY A  84
ASP A  87
SER A  61
 None
 1.21A 4rfqA-2w37A:
2.1		 4rfqA-2w37A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 THR A 334
LEU A 335
PRO A  80
SER A  73
ALA A  78
 None
 1.22A 4ypmA-2w37A:
undetectable		 4ypmA-2w37A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 GLY A 181
LEU A 177
SER A 176
VAL A 151
VAL A 232
 None
 1.05A 5dpdA-2w37A:
4.6		 5dpdA-2w37A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 GLY A 181
LEU A 177
SER A 176
VAL A 151
VAL A 232
 None
 1.14A 5dpdB-2w37A:
4.3		 5dpdB-2w37A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		5 / 12 ALA A 174
GLN A 159
GLY A 181
SER A 176
GLU A  18
 None
 1.33A 5hfjG-2w37A:
2.2		 5hfjG-2w37A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC
(Lactobacillus
hilgardii) 		4 / 7 ILE A 205
PHE A 197
ILE A 219
PHE A 165
 None
 0.85A 5hieC-2w37A:
undetectable		 5hieC-2w37A:
23.00