SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 120
ALA A 130
ASP A  79
GLY A  82
PHE A 118
 None
 1.15A 1d4sA-2w38A:
undetectable		 1d4sA-2w38A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 196
VAL A 188
ILE A 211
ARG A 268
 None
None
None
GOL  A1441 ( 4.1A)
 1.14A 1iepA-2w38A:
undetectable		 1iepA-2w38A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 270
VAL A 253
VAL A 142
ILE A 173
 None
 0.87A 1uwhB-2w38A:
undetectable		 1uwhB-2w38A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 146
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 0.89A 1v3eA-2w38A:
5.7		 1v3eA-2w38A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 146
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 0.88A 1v3eB-2w38A:
7.6		 1v3eB-2w38A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 397
GLY A 398
LEU A 348
LEU A 404
LEU A 351
 None
 1.07A 2egvB-2w38A:
undetectable		 2egvB-2w38A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 146
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 0.77A 2f0zA-2w38A:
9.9		 2f0zA-2w38A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A  78
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 1.42A 2f10A-2w38A:
30.2		 2f10A-2w38A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 146
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 0.74A 2f10A-2w38A:
30.2		 2f10A-2w38A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  79
TYR A 146
ARG A 198
ARG A 260
TYR A 297
 None
 0.72A 2ya7A-2w38A:
33.2		 2ya7A-2w38A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  79
TYR A 146
ARG A 198
ARG A 260
TYR A 297
 None
 0.72A 2ya7B-2w38A:
33.3		 2ya7B-2w38A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  79
TYR A 146
ARG A 198
ARG A 260
TYR A 297
 None
 0.70A 2ya7C-2w38A:
32.7		 2ya7C-2w38A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  79
TYR A 146
ARG A 198
ARG A 260
TYR A 297
 None
 0.72A 2ya7D-2w38A:
33.1		 2ya7D-2w38A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 247
GLY A 249
THR A 250
 None
 0.59A 3iazA-2w38A:
undetectable		 3iazA-2w38A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 196
VAL A 188
ILE A 211
ARG A 268
 None
None
None
GOL  A1441 ( 4.1A)
 1.09A 3ms9A-2w38A:
undetectable		 3ms9A-2w38A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 196
VAL A 188
ILE A 211
ARG A 268
 None
None
None
GOL  A1441 ( 4.1A)
 1.07A 3mssA-2w38A:
undetectable		 3mssA-2w38A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 196
VAL A 188
ILE A 211
ARG A 268
 None
None
None
GOL  A1441 ( 4.1A)
 1.08A 3mssC-2w38A:
undetectable		 3mssC-2w38A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 323
TYR A 297
ASN A 311
LEU A  11
TYR A  36
 None
 1.26A 3rc0A-2w38A:
undetectable		 3rc0A-2w38A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 9 THR A 319
THR A 320
TYR A  17
GLY A 322
ASP A  22
 GOL  A1442 (-4.0A)
GOL  A1442 ( 4.7A)
None
None
None
 1.41A 3sfuA-2w38A:
undetectable		 3sfuA-2w38A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 145
VAL A 104
LEU A 120
GLY A 163
ASP A 162
 None
 1.10A 3uq6B-2w38A:
undetectable		 3uq6B-2w38A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 310
ILE A 308
GLN A 300
VAL A 288
 None
 1.14A 4d39B-2w38A:
undetectable		 4d39B-2w38A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 5 GLY A 296
SER A 295
ALA A 294
PHE A 313
GLU A 315
 None
 1.24A 4m93B-2w38A:
undetectable
4m93C-2w38A:
2.1		 4m93B-2w38A:
20.45
4m93C-2w38A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A  78
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 1.17A 4mwrA-2w38A:
20.1		 4mwrA-2w38A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  79
ASN A 181
SER A 299
 None
 0.82A 4obwA-2w38A:
undetectable		 4obwA-2w38A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 308
GLN A 300
ILE A  29
ASP A  28
 None
 0.93A 4w5tA-2w38A:
undetectable		 4w5tA-2w38A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 9 ARG A 260
ARG A 198
LEU A 255
SER A 240
ALA A 238
 None
 1.37A 4z69A-2w38A:
undetectable		 4z69A-2w38A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  20
THR A 320
THR A  43
 GOL  A1439 ( 3.5A)
GOL  A1442 ( 4.7A)
GOL  A1442 (-4.2A)
 0.78A 5aoxB-2w38A:
undetectable		 5aoxB-2w38A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  20
THR A 320
THR A  43
 GOL  A1439 ( 3.5A)
GOL  A1442 ( 4.7A)
GOL  A1442 (-4.2A)
 0.83A 5aoxE-2w38A:
2.5		 5aoxE-2w38A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 311
GLN A  26
HIS A 131
ALA A 238
GLY A 296
 None
 1.46A 5cp3A-2w38A:
undetectable
5cp3H-2w38A:
0.0		 5cp3A-2w38A:
19.29
5cp3H-2w38A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 355
ILE A 438
PRO A 334
LEU A 271
 None
 1.24A 5eb3A-2w38A:
undetectable		 5eb3A-2w38A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  58
LYS A  57
ASP A  32
GLY A  33
LEU A 309
 None
 1.12A 5kbwA-2w38A:
undetectable		 5kbwA-2w38A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A  78
GLU A 182
ARG A 198
ARG A 260
TYR A 297
 None
 1.20A 5l17A-2w38A:
20.2		 5l17A-2w38A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  55
ARG A  89
ILE A  90
GLY A  88
 None
 0.97A 5nzxA-2w38A:
undetectable		 5nzxA-2w38A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 289
ALA A  15
TYR A 324
 None
 0.84A 5uunB-2w38A:
undetectable		 5uunB-2w38A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  25
TRP A  63
ASP A  22
TYR A  21
 None
 1.16A 5vlmG-2w38A:
undetectable		 5vlmG-2w38A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  30
LEU A  11
GLY A  82
GLY A 310
VAL A 301
 None
 1.19A 6eu9B-2w38A:
undetectable		 6eu9B-2w38A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 2w38 SIALIDASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 185
ASN A 181
TYR A 180
PHE A 210
 None
 1.46A 6h3dA-2w38A:
undetectable		 6h3dA-2w38A:
18.74