SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 8 ILE A  78
LEU A  65
ILE A  66
HIS A  67
 None
 0.90A 2azxA-2w3cA:
undetectable		 2azxA-2w3cA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 142
GLY A  80
LEU A  69
ILE A  79
 None
 0.92A 3ku1A-2w3cA:
undetectable		 3ku1A-2w3cA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 142
GLY A  80
LEU A  69
ILE A  79
 None
 0.90A 3ku1C-2w3cA:
undetectable		 3ku1C-2w3cA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 142
GLY A  80
LEU A  69
ILE A  79
 None
 0.89A 3ku1H-2w3cA:
undetectable		 3ku1H-2w3cA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 8 ILE A 584
GLN A 535
ALA A 542
LEU A 543
 None
 0.74A 3ozwA-2w3cA:
undetectable		 3ozwA-2w3cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 9 LEU A 386
ALA A 440
VAL A 373
GLY A 422
ILE A 403
 None
 1.22A 3spkA-2w3cA:
undetectable		 3spkA-2w3cA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 9 PHE A 613
PHE A 609
VAL A 492
ILE A 584
GLY A 539
 None
 1.36A 3t3rC-2w3cA:
undetectable		 3t3rC-2w3cA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 6 VAL A 509
LEU A 513
PHE A 613
MET A 496
 None
 1.07A 4o1zA-2w3cA:
undetectable		 4o1zA-2w3cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 11 ARG A  73
LEU A  69
VAL A 138
LEU A 126
LEU A  86
 None
 1.26A 4or0B-2w3cA:
2.5		 4or0B-2w3cA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 9 LEU A 316
GLY A 311
VAL A 340
VAL A 287
LEU A 290
 None
 1.11A 4qd3A-2w3cA:
undetectable		 4qd3A-2w3cA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 8 ILE A 182
LEU A 149
LEU A 171
ILE A 161
 None
 0.73A 4r38A-2w3cA:
undetectable		 4r38A-2w3cA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 5 ALA A 327
THR A 331
VAL A 385
ILE A 334
 None
 0.76A 4xe3A-2w3cA:
undetectable		 4xe3A-2w3cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 5 ALA A 327
THR A 331
VAL A 385
ILE A 334
 None
 0.77A 4xe3B-2w3cA:
undetectable		 4xe3B-2w3cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 7 PHE A 577
ILE A 568
GLY A 546
THR A 625
 None
 1.13A 4zxiA-2w3cA:
undetectable		 4zxiA-2w3cA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		5 / 9 LEU A 126
LEU A  65
LEU A  69
LEU A  83
ALA A  82
 None
 1.09A 5dqfA-2w3cA:
2.3		 5dqfA-2w3cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens) 		4 / 5 TYR A 350
VAL A 385
MET A 307
GLY A 311
 None
 1.32A 6hd4A-2w3cA:
undetectable		 6hd4A-2w3cA:
8.53