SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 127
GLY A 122
GLY A 119
GLU A  87
PHE A 155
 None
None
HEM  A 500 (-3.1A)
None
None
 1.17A 1w76A-2w3gA:
undetectable		 1w76A-2w3gA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 103
PHE A  98
GLY A  84
HIS A 149
PRO A 150
 HEM  A 500 (-4.2A)
HEM  A 500 (-4.9A)
HEM  A 500 (-4.4A)
HEM  A 500 (-3.3A)
None
 1.42A 2y7kA-2w3gA:
undetectable		 2y7kA-2w3gA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 103
PHE A  98
GLY A  84
HIS A 149
PRO A 150
 HEM  A 500 (-4.2A)
HEM  A 500 (-4.9A)
HEM  A 500 (-4.4A)
HEM  A 500 (-3.3A)
None
 1.31A 2y7wB-2w3gA:
undetectable		 2y7wB-2w3gA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  72
VAL A 200
GLY A 197
ALA A 196
LEU A 192
 None
 1.01A 3hs6A-2w3gA:
undetectable		 3hs6A-2w3gA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 200
LEU A 172
ILE A 121
LEU A  68
 None
 0.76A 3kk6A-2w3gA:
undetectable		 3kk6A-2w3gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 200
LEU A 172
ILE A 121
LEU A  68
 None
 0.76A 3kk6B-2w3gA:
undetectable		 3kk6B-2w3gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  89
GLY A 122
ILE A 125
 None
 0.33A 4k50A-2w3gA:
undetectable		 4k50A-2w3gA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  89
GLY A 122
ILE A 125
 None
 0.31A 4k50I-2w3gA:
undetectable		 4k50I-2w3gA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  81
ILE A 121
VAL A 120
GLY A 157
VAL A 136
 None
None
HEM  A 500 ( 3.4A)
None
None
 1.04A 4r20B-2w3gA:
undetectable		 4r20B-2w3gA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 194
ALA A 196
LEU A 170
ALA A 191
ILE A 125
HIS A  93
 None
 1.44A 6a60D-2w3gA:
undetectable		 6a60D-2w3gA:
18.83