SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
6 / 12 GLY A  60
ASP A  32
ILE A  31
GLY A  29
ILE A 124
ILE A 121
None
CA  A1138 (-3.3A)
None
CA  A1139 (-4.4A)
None
None
1.40A 1hshA-2w3jA:
undetectable
1hshA-2w3jA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
4 / 5 VAL A  71
LEU A 110
ILE A 124
ALA A  55
None
0.91A 3n8yB-2w3jA:
undetectable
3n8yB-2w3jA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
3 / 3 GLN A  56
THR A  54
ASN A  96
None
0.87A 3v4tE-2w3jA:
undetectable
3v4tE-2w3jA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
5 / 12 VAL A  71
GLN A  93
PHE A  59
ILE A  57
PHE A  83
None
1.26A 4c49C-2w3jA:
undetectable
4c49C-2w3jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
5 / 12 VAL A  71
GLN A  93
PHE A  59
ILE A  57
PHE A  83
None
1.19A 4c49D-2w3jA:
undetectable
4c49D-2w3jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
4 / 7 VAL A  71
ILE A  78
VAL A  97
ILE A  57
None
0.64A 5bmvC-2w3jA:
undetectable
5bmvC-2w3jA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
4 / 7 ILE A 124
VAL A 126
ILE A  99
THR A  52
None
1.00A 6cduF-2w3jA:
undetectable
6cduG-2w3jA:
undetectable
6cduF-2w3jA:
18.35
6cduG-2w3jA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium)
4 / 6 ARG A  67
ALA A 119
LEU A 118
ALA A 112
CA  A1138 ( 4.5A)
None
None
None
1.05A 6fosB-2w3jA:
undetectable
6fosB-2w3jA:
19.57