SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
6 / 8 CYH A  68
ASP A  70
HIS A 124
CYH A 127
GLY A 128
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.4A)
ACT  A1233 (-3.9A)
0.23A 1ekjA-2w3nA:
21.4
1ekjB-2w3nA:
21.1
1ekjA-2w3nA:
27.91
1ekjB-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 8 CYH A  68
ASP A  70
HIS A 124
CYH A 127
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.9A)
0.97A 1ekjA-2w3nA:
21.4
1ekjB-2w3nA:
21.1
1ekjA-2w3nA:
27.91
1ekjB-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 8 CYH A  68
ASP A  70
HIS A 124
CYH A 127
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.9A)
0.98A 1ekjA-2w3nA:
21.4
1ekjB-2w3nA:
21.1
1ekjA-2w3nA:
27.91
1ekjB-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
6 / 8 CYH A  68
ASP A  70
VAL A  92
HIS A 124
CYH A 127
GLY A 128
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.4A)
0.28A 1ekjA-2w3nA:
21.4
1ekjB-2w3nA:
21.1
1ekjA-2w3nA:
27.91
1ekjB-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 6 CYH A  68
ASP A  70
VAL A  92
GLY A 128
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ACT  A1233 (-3.4A)
0.18A 1ekjC-2w3nA:
21.3
1ekjD-2w3nA:
21.4
1ekjC-2w3nA:
27.91
1ekjD-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 6 CYH A  68
ASP A  70
VAL A  92
GLY A 128
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ACT  A1233 (-3.4A)
0.17A 1ekjC-2w3nA:
21.3
1ekjD-2w3nA:
21.4
1ekjC-2w3nA:
27.91
1ekjD-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 7 CYH A  68
ASP A  70
HIS A 124
GLY A 128
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ACT  A1233 (-3.4A)
ACT  A1233 (-3.9A)
0.19A 1ekjE-2w3nA:
21.2
1ekjF-2w3nA:
21.3
1ekjE-2w3nA:
27.91
1ekjF-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 7 CYH A  68
ASP A  70
HIS A 124
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ACT  A1233 (-3.9A)
0.88A 1ekjE-2w3nA:
21.2
1ekjF-2w3nA:
21.3
1ekjE-2w3nA:
27.91
1ekjF-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 8 CYH A  68
ASP A  70
VAL A  92
GLY A 128
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ACT  A1233 (-3.4A)
ACT  A1233 (-3.9A)
0.20A 1ekjE-2w3nA:
21.2
1ekjF-2w3nA:
21.2
1ekjE-2w3nA:
27.91
1ekjF-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 8 CYH A  68
ASP A  70
HIS A 124
CYH A 127
GLY A 128
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.4A)
1.02A 1ekjG-2w3nA:
21.3
1ekjH-2w3nA:
21.4
1ekjG-2w3nA:
27.91
1ekjH-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
6 / 8 CYH A  68
ASP A  70
HIS A 124
CYH A 127
GLY A 128
GLY A 129
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.4A)
ACT  A1233 (-3.9A)
0.18A 1ekjG-2w3nA:
21.3
1ekjH-2w3nA:
21.4
1ekjG-2w3nA:
27.91
1ekjH-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 6 CYH A  68
ASP A  70
VAL A  92
HIS A 124
CYH A 127
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
0.24A 1ekjG-2w3nA:
21.3
1ekjH-2w3nA:
21.4
1ekjG-2w3nA:
27.91
1ekjH-2w3nA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 9 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
None
1.47A 1mj2A-2w3nA:
undetectable
1mj2A-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 9 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
None
1.50A 1mjoB-2w3nA:
undetectable
1mjoB-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 11 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
None
1.45A 1mjqA-2w3nA:
undetectable
1mjqB-2w3nA:
undetectable
1mjqA-2w3nA:
20.35
1mjqB-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
None
1.41A 1mjqC-2w3nA:
undetectable
1mjqD-2w3nA:
undetectable
1mjqC-2w3nA:
20.35
1mjqD-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
None
1.45A 1mjqG-2w3nA:
undetectable
1mjqH-2w3nA:
undetectable
1mjqG-2w3nA:
20.35
1mjqH-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 5 ALA A  69
GLY A 129
CYH A 127
HIS A 124
None
ACT  A1233 (-3.9A)
ZN  A1232 ( 2.3A)
ZN  A1232 ( 3.3A)
1.48A 2ylgA-2w3nA:
undetectable
2ylgA-2w3nA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
7 / 10 CYH A  68
ASP A  70
VAL A  92
HIS A 124
CYH A 127
GLY A 128
ALA A 132
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.4A)
None
0.21A 3ucjA-2w3nA:
24.3
3ucjA-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 CYH A  68
HIS A 124
CYH A 127
GLY A 129
ALA A 133
ZN  A1232 ( 2.2A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.9A)
None
1.16A 3ucjA-2w3nA:
24.3
3ucjA-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 CYH A  68
VAL A  92
HIS A 124
CYH A 127
ALA A 133
ZN  A1232 ( 2.2A)
ACT  A1233 ( 4.1A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
None
0.90A 3ucjA-2w3nA:
24.3
3ucjA-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
3 / 3 GLN A  59
PHE A  87
TYR A 109
None
0.46A 3ucjB-2w3nA:
25.0
3ucjB-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
3 / 3 GLN A  59
PHE A  87
TYR A 109
None
0.44A 3ucjA-2w3nA:
24.3
3ucjA-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 ASP A  70
HIS A 124
CYH A 127
GLY A 129
ALA A  93
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.9A)
None
1.19A 3ucjB-2w3nA:
25.0
3ucjB-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
6 / 10 CYH A  68
ASP A  70
HIS A 124
CYH A 127
GLY A 129
ALA A 132
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.9A)
None
1.31A 3ucjB-2w3nA:
25.0
3ucjB-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
7 / 10 CYH A  68
ASP A  70
VAL A  92
HIS A 124
CYH A 127
GLY A 128
ALA A 132
ZN  A1232 ( 2.2A)
ACT  A1233 (-3.8A)
ACT  A1233 ( 4.1A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.4A)
None
0.25A 3ucjB-2w3nA:
25.0
3ucjB-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 CYH A  68
HIS A 124
CYH A 127
GLY A 129
ALA A 133
ZN  A1232 ( 2.2A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
ACT  A1233 (-3.9A)
None
1.17A 3ucjB-2w3nA:
25.0
3ucjB-2w3nA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
5 / 10 CYH A  68
VAL A  92
HIS A 124
CYH A 127
ALA A 133
ZN  A1232 ( 2.2A)
ACT  A1233 ( 4.1A)
ZN  A1232 ( 3.3A)
ZN  A1232 ( 2.3A)
None
0.89A 3ucjB-2w3nA:
25.0
3ucjB-2w3nA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 7 GLY A 192
MET A 112
ASN A 108
GLU A 195
None
0.89A 4fgkB-2w3nA:
2.6
4fgkB-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 5 GLY A 192
MET A 112
ASN A 108
GLU A 195
None
0.95A 4fglC-2w3nA:
2.4
4fglC-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 6 GLY A 192
MET A 112
ASN A 108
GLU A 195
None
0.92A 4fglD-2w3nA:
undetectable
4fglD-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 7 VAL A 184
ILE A 190
VAL A 119
ILE A  66
None
0.74A 5bmvC-2w3nA:
undetectable
5bmvC-2w3nA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 4 VAL A 122
GLY A  67
ARG A  90
VAL A  73
None
1.31A 5d4nA-2w3nA:
undetectable
5d4nB-2w3nA:
undetectable
5d4nA-2w3nA:
22.59
5d4nB-2w3nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 5 ALA A  69
GLY A 129
CYH A 127
HIS A 124
None
ACT  A1233 (-3.9A)
ZN  A1232 ( 2.3A)
ZN  A1232 ( 3.3A)
1.49A 5jliA-2w3nA:
undetectable
5jliA-2w3nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 4 ALA A  69
GLY A 129
CYH A 127
HIS A 124
None
ACT  A1233 (-3.9A)
ZN  A1232 ( 2.3A)
ZN  A1232 ( 3.3A)
1.49A 5jslA-2w3nA:
undetectable
5jslA-2w3nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')
2w3n CARBONIC ANHYDRASE 2
(Cryptococcus
neoformans)
4 / 5 ALA A  69
GLY A 129
CYH A 127
HIS A 124
None
ACT  A1233 (-3.9A)
ZN  A1232 ( 2.3A)
ZN  A1232 ( 3.3A)
1.48A 5jt4A-2w3nA:
undetectable
5jt4A-2w3nA:
20.94