SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A  32
LEU A 130
LEU A 236
ALA A 237
PHE A 132
 None
 1.07A 1g5yC-2w3pA:
undetectable		 1g5yC-2w3pA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 0.91A 1hrkA-2w3pA:
undetectable		 1hrkA-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 1.02A 1hrkB-2w3pA:
undetectable		 1hrkB-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A 173
VAL A 169
GLU A 168
GLU A 146
 None
 0.85A 1pk7B-2w3pA:
undetectable		 1pk7B-2w3pA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 4 VAL A 190
ALA A 195
LEU A 166
PHE A 198
 None
 1.16A 1q97B-2w3pA:
undetectable		 1q97B-2w3pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 ALA A 150
LEU A 149
GLY A 180
GLY A 143
 None
 0.83A 1rukH-2w3pA:
undetectable
1rukL-2w3pA:
undetectable		 1rukH-2w3pA:
18.52
1rukL-2w3pA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 6 VAL A  31
THR A  79
LEU A 234
ARG A 232
 None
 0.98A 1s8fB-2w3pA:
2.1		 1s8fB-2w3pA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 310
PHE A 313
LEU A 368
GLY A 390
PHE A 392
 None
 1.39A 1uhoA-2w3pA:
undetectable		 1uhoA-2w3pA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A  85
THR A  33
ILE A  36
LEU A 234
VAL A  31
 None
None
BME  A 602 (-3.9A)
None
None
 1.47A 2n27A-2w3pA:
0.0		 2n27A-2w3pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 0.83A 2po5A-2w3pA:
undetectable		 2po5A-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 0.89A 2po5B-2w3pA:
2.4		 2po5B-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		3 / 3 ASN A  53
LEU A  50
HIS A  22
 None
 0.81A 2q6fB-2w3pA:
0.0		 2q6fB-2w3pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 368
LEU A 364
ILE A 371
ARG A 370
 None
 0.83A 2rlfA-2w3pA:
undetectable
2rlfB-2w3pA:
undetectable		 2rlfA-2w3pA:
5.55
2rlfB-2w3pA:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 6 THR A 391
GLU A 394
MET A 349
ILE A 361
 None
 1.25A 2w98B-2w3pA:
undetectable		 2w98B-2w3pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 142
GLY A 144
ALA A 148
LEU A 149
VAL A 202
 None
 1.00A 2zulA-2w3pA:
undetectable		 2zulA-2w3pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 PHE A  90
LEU A 171
GLY A  93
ILE A  36
ASP A  37
 None
None
None
BME  A 602 (-3.9A)
None
 1.31A 2zznB-2w3pA:
undetectable		 2zznB-2w3pA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 142
GLY A 144
ALA A 148
LEU A 149
VAL A 202
 None
 1.04A 3dmhA-2w3pA:
undetectable		 3dmhA-2w3pA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A 425
ALA A 437
SER A 434
GLU A 442
 None
 0.73A 3u9hA-2w3pA:
undetectable		 3u9hA-2w3pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A 425
ALA A 437
SER A 434
GLU A 442
 None
 0.75A 3u9hB-2w3pA:
undetectable		 3u9hB-2w3pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A 425
ALA A 437
SER A 434
GLU A 442
 None
 0.73A 4bjcA-2w3pA:
undetectable		 4bjcA-2w3pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 LEU A  82
LEU A  34
GLY A  35
VAL A  59
 None
None
None
BME  A 602 (-4.6A)
 0.78A 4c9nA-2w3pA:
undetectable		 4c9nA-2w3pA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 11 SER A  92
PHE A  97
LEU A  50
VAL A  59
THR A 178
 None
None
None
BME  A 602 (-4.6A)
BME  A 601 (-4.1A)
 1.44A 4eilE-2w3pA:
2.5		 4eilE-2w3pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A  36
LEU A  50
LEU A 147
GLY A 144
PHE A  90
 BME  A 602 (-3.9A)
None
BME  A 602 (-4.6A)
None
None
 1.19A 4foxA-2w3pA:
undetectable		 4foxA-2w3pA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A  36
LEU A  50
LEU A 147
GLY A 144
PHE A  90
 BME  A 602 (-3.9A)
None
BME  A 602 (-4.6A)
None
None
 1.13A 4foxB-2w3pA:
undetectable		 4foxB-2w3pA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 7 GLN A 524
THR A 178
THR A 114
THR A 511
 BME  A 601 (-4.4A)
BME  A 601 (-4.1A)
None
None
 1.07A 4mbsA-2w3pA:
undetectable		 4mbsA-2w3pA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 TYR A  48
GLY A  47
LEU A 540
LEU A 172
ALA A  94
 None
None
None
None
BME  A 601 ( 4.5A)
 1.25A 4wcxC-2w3pA:
undetectable		 4wcxC-2w3pA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 5 PHE A  72
PRO A 250
VAL A 249
ALA A 302
 None
 1.33A 4z4cA-2w3pA:
undetectable		 4z4cA-2w3pA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  82
PRO A 167
LEU A 166
GLU A 146
CYH A 151
 None
 1.43A 5emlA-2w3pA:
undetectable		 5emlA-2w3pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 368
ALA A 398
LEU A 395
THR A 280
ILE A 317
 None
 1.07A 5itzB-2w3pA:
undetectable		 5itzB-2w3pA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 7 LEU A 318
GLU A 324
ILE A  44
VAL A  11
 None
 1.10A 5jh7C-2w3pA:
undetectable		 5jh7C-2w3pA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		3 / 3 GLY A 177
THR A 521
ASN A 115
 BME  A 601 (-3.7A)
None
None
 0.68A 5odiG-2w3pA:
2.1		 5odiG-2w3pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A  93
ILE A  38
TRP A  23
ASP A  56
 None
 0.89A 5vlmD-2w3pA:
undetectable		 5vlmD-2w3pA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A  93
ILE A  38
TRP A  23
ASP A  56
 None
 0.81A 5vlmH-2w3pA:
undetectable		 5vlmH-2w3pA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 4 GLY A 120
ARG A 183
ASN A 119
LEU A 121
 None
 1.41A 6b58A-2w3pA:
undetectable		 6b58A-2w3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 172
VAL A 534
TYR A 543
GLY A 538
LEU A  99
 None
 1.15A 6bsiA-2w3pA:
undetectable		 6bsiA-2w3pA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2w3p BENZOYL-COA-DIHYDROD
IOL LYASE
(Paraburkholderia
xenovorans) 		4 / 7 ALA A 310
THR A 367
ILE A 317
ALA A 316
 None
 0.90A 6ma7A-2w3pA:
undetectable		 6ma7A-2w3pA:
8.96