SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 12 ASP A 244
ILE A 230
GLY A  63
ILE A  65
VAL A 243
 None
 0.91A 2b7zB-2w3yA:
undetectable		 2b7zB-2w3yA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 11 ASP A 244
ILE A 230
GLY A  63
ILE A  65
VAL A 243
 None
 0.89A 2nnpB-2w3yA:
undetectable		 2nnpB-2w3yA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 9 VAL A 243
PHE A 239
PHE A 191
PHE A 106
VAL A  10
 None
 1.21A 3me6C-2w3yA:
undetectable		 3me6C-2w3yA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 9 VAL A 243
PHE A 239
PHE A 191
PHE A 106
VAL A  10
 None
 1.26A 3me6D-2w3yA:
undetectable		 3me6D-2w3yA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 4 LEU A 155
GLY A 154
GLY A 152
THR A 207
 None
None
PLM  A1278 ( 4.2A)
None
 0.69A 3si7A-2w3yA:
undetectable		 3si7A-2w3yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		3 / 3 GLY A 154
GLY A 152
THR A 207
 None
PLM  A1278 ( 4.2A)
None
 0.44A 3si7B-2w3yA:
undetectable		 3si7B-2w3yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 8 PHE A 105
PHE A 106
PHE A 246
ALA A  74
 None
 0.93A 3t3sF-2w3yA:
undetectable		 3t3sF-2w3yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 11 ALA A 126
LEU A 148
PHE A 144
PHE A 219
VAL A 221
 None
PLM  A1278 (-4.2A)
None
PLM  A1278 ( 3.7A)
None
 1.46A 4claA-2w3yA:
undetectable		 4claA-2w3yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 8 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.95A 4fglD-2w3yA:
undetectable		 4fglD-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 7 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.88A 4fglC-2w3yA:
undetectable		 4fglC-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		3 / 3 SER A 156
MET A 159
ASP A 259
 None
 0.96A 4mm4B-2w3yA:
undetectable		 4mm4B-2w3yA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 6 TYR A 166
ASP A 259
VAL A  71
ALA A  72
 None
 1.00A 4nkvC-2w3yA:
undetectable		 4nkvC-2w3yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 8 LYS A 127
ALA A 126
GLY A 122
LEU A 148
 None
None
None
PLM  A1278 (-4.2A)
 0.86A 4po0A-2w3yA:
undetectable		 4po0A-2w3yA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 6 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 1.01A 4qogA-2w3yA:
undetectable
4qogB-2w3yA:
undetectable		 4qogA-2w3yA:
21.58
4qogB-2w3yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 9 GLY A  35
VAL A  42
ALA A 171
ASN A  79
VAL A  78
 None
 1.03A 5lw1H-2w3yA:
undetectable		 5lw1H-2w3yA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 12 VAL A  71
LEU A 155
PHE A 198
THR A 196
GLY A 195
 None
None
None
PLM  A1278 ( 4.8A)
None
 1.05A 6brdA-2w3yA:
undetectable		 6brdA-2w3yA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 12 ASP A 244
ILE A 230
GLY A  63
ILE A  65
VAL A 243
 None
 0.86A 6dh0A-2w3yA:
undetectable		 6dh0A-2w3yA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 5 TYR A 277
ASN A 135
ARG A 190
PHE A 178
 None
 1.19A 6h3dA-2w3yA:
0.0		 6h3dA-2w3yA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 11 PHE A 144
ASN A 272
ASP A 176
PHE A 266
ASN A  50
 None
 1.35A 6r2eG-2w3yA:
undetectable		 6r2eG-2w3yA:
20.93