SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		4 / 4 THR A 220
LEU A 222
LEU A 229
GLN A 232
 None
 1.13A 1fbmA-2w3zA:
undetectable		 1fbmA-2w3zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 12 LEU A 217
ASP A 238
TYR A 172
HIS A 170
HIS A 166
 None
None
None
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
 1.20A 1tmxB-2w3zA:
undetectable		 1tmxB-2w3zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 11 LEU A 201
LEU A 197
ILE A 152
THR A 122
PRO A 123
 None
 1.17A 2ft9A-2w3zA:
undetectable		 2ft9A-2w3zA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 12 THR A 207
ALA A  87
ALA A  83
ILE A 157
LEU A 126
 None
 1.14A 2nyrA-2w3zA:
undetectable		 2nyrA-2w3zA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 11 LEU A 290
VAL A 243
ILE A 125
PHE A 113
LEU A 129
 None
 1.08A 2q6hA-2w3zA:
undetectable		 2q6hA-2w3zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 12 LEU A 290
VAL A 243
ILE A 125
PHE A 113
LEU A 129
 None
 1.09A 2qb4A-2w3zA:
undetectable		 2qb4A-2w3zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 11 LEU A 290
VAL A 243
ILE A 125
PHE A 113
LEU A 129
 None
 1.08A 2qeiA-2w3zA:
undetectable		 2qeiA-2w3zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		4 / 6 ASP A 114
LEU A 140
LEU A 129
HIS A 161
 PO4  A1313 (-3.4A)
None
None
None
 1.18A 3bj8C-2w3zA:
undetectable
3bj8D-2w3zA:
undetectable		 3bj8C-2w3zA:
18.91
3bj8D-2w3zA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 TYR A 172
GLY A 214
PRO A 213
 None
PO4  A1313 (-3.6A)
PO4  A1313 (-4.6A)
 0.70A 4qwpA-2w3zA:
undetectable		 4qwpA-2w3zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 12 ILE A 297
VAL A 278
LEU A 129
PHE A 307
MET A 280
 None
 1.20A 5bykA-2w3zA:
undetectable		 5bykA-2w3zA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 MET A  96
GLN A  95
ARG A  94
 None
 1.00A 5ewzB-2w3zA:
undetectable		 5ewzB-2w3zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 MET A  96
GLN A  95
ARG A  94
 None
 0.98A 5m35B-2w3zA:
undetectable		 5m35B-2w3zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 MET A  96
GLN A  95
ARG A  94
 None
 0.96A 5m36A-2w3zA:
undetectable		 5m36A-2w3zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 6 ASP A 114
ASP A 115
HIS A 166
HIS A 170
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
PO4  A1313 (-3.9A)
 0.23A 5ncdA-2w3zA:
22.0
5ncdD-2w3zA:
22.2		 5ncdA-2w3zA:
26.40
5ncdD-2w3zA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 6 ASP A 114
ASP A 115
HIS A 166
HIS A 170
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
PO4  A1313 (-3.9A)
 0.24A 5ncdB-2w3zA:
22.2
5ncdC-2w3zA:
22.1		 5ncdB-2w3zA:
26.40
5ncdC-2w3zA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		4 / 4 ASP A 114
HIS A 166
HIS A 170
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
PO4  A1313 (-3.9A)
 0.17A 5ncdD-2w3zA:
22.2		 5ncdD-2w3zA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		6 / 8 ASP A 114
ASP A 115
HIS A 166
HIS A 170
PRO A 213
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
PO4  A1313 (-4.6A)
PO4  A1313 (-3.9A)
 0.31A 5nekB-2w3zA:
22.0		 5nekB-2w3zA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		4 / 8 ASP A 114
HIS A 166
HIS A 170
ARG A 252
 PO4  A1313 (-3.4A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
None
 0.96A 5nekB-2w3zA:
22.0		 5nekB-2w3zA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		6 / 8 ASP A 114
ASP A 115
HIS A 166
HIS A 170
TRP A 239
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
None
PO4  A1313 (-3.9A)
 0.38A 5nekD-2w3zA:
22.1		 5nekD-2w3zA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 8 ASP A 114
HIS A 166
HIS A 170
ARG A 252
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
None
PO4  A1313 (-3.9A)
 1.20A 5nekD-2w3zA:
22.1		 5nekD-2w3zA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 6 ASP A 114
ASP A 115
HIS A 166
HIS A 170
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
PO4  A1313 (-3.9A)
 0.21A 5nelA-2w3zA:
22.1
5nelD-2w3zA:
22.1		 5nelA-2w3zA:
26.40
5nelD-2w3zA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 6 ASP A 114
HIS A 166
HIS A 170
LEU A 279
HIS A 281
 PO4  A1313 (-3.4A)
ZN  A1312 ( 3.3A)
ZN  A1312 ( 3.3A)
None
PO4  A1313 (-3.9A)
 0.26A 5nelB-2w3zA:
22.0
5nelC-2w3zA:
22.1		 5nelB-2w3zA:
26.40
5nelC-2w3zA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 HIS A 281
ASP A 115
HIS A 166
 PO4  A1313 (-3.9A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
 0.77A 5oexB-2w3zA:
undetectable		 5oexB-2w3zA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 HIS A 281
ASP A 115
HIS A 166
 PO4  A1313 (-3.9A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
 0.76A 5oexC-2w3zA:
undetectable		 5oexC-2w3zA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 HIS A 281
ASP A 115
HIS A 166
 PO4  A1313 (-3.9A)
ZN  A1312 (-2.6A)
ZN  A1312 ( 3.3A)
 0.76A 5oexD-2w3zA:
undetectable		 5oexD-2w3zA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 12 TYR A  86
LEU A 111
VAL A 134
HIS A 135
LEU A 129
 None
 1.23A 5ubbA-2w3zA:
undetectable		 5ubbA-2w3zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMX_B_RBFB202_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 10 LEU A 229
GLN A 232
GLY A 142
HIS A 166
GLN A 194
 None
None
None
ZN  A1312 ( 3.3A)
None
 1.50A 5umxA-2w3zA:
0.0
5umxB-2w3zA:
0.0		 5umxA-2w3zA:
13.96
5umxB-2w3zA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		4 / 5 THR A 146
THR A 122
HIS A 161
LEU A 163
 None
 1.32A 5utuH-2w3zA:
2.5		 5utuH-2w3zA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		5 / 12 ILE A 297
VAL A 278
LEU A 129
PHE A 307
MET A 280
 None
 1.24A 6b52A-2w3zA:
undetectable		 6b52A-2w3zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 MET A  96
GLN A  95
ARG A  94
 None
 0.98A 6fn9A-2w3zA:
undetectable		 6fn9A-2w3zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 MET A  96
GLN A  95
ARG A  94
 None
 0.98A 6fnaB-2w3zA:
undetectable		 6fnaB-2w3zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2w3z PUTATIVE DEACETYLASE
(Streptococcus
mutans) 		3 / 3 MET A  96
GLN A  95
ARG A  94
 None
 0.98A 6fnbA-2w3zA:
undetectable		 6fnbA-2w3zA:
21.38