SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 12 GLY A 442
ALA A 441
GLY A 461
PRO A  42
ILE A 197
 None
 1.01A 1c6zA-2w45A:
undetectable		 1c6zA-2w45A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 7 LEU A 216
SER A 108
SER A 104
THR A 100
 None
 0.96A 1dvxA-2w45A:
undetectable		 1dvxA-2w45A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 8 LEU A  49
GLY A 196
LEU A 122
TYR A  48
 None
 0.82A 1jlbA-2w45A:
undetectable		 1jlbA-2w45A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
ILE A 127
TRP A 444
 None
 1.16A 1m8eB-2w45A:
undetectable		 1m8eB-2w45A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 8 SER A 129
SER A 128
ILE A 126
GLY A 125
 None
 0.77A 1me7A-2w45A:
undetectable		 1me7A-2w45A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 10 GLY A 442
ALA A 441
GLY A 461
PRO A  42
ILE A 197
 None
 0.98A 1muiA-2w45A:
undetectable		 1muiA-2w45A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.81A 2nmzA-2w45A:
undetectable		 2nmzA-2w45A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.76A 2nnkA-2w45A:
undetectable		 2nnkA-2w45A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 10 LEU A 462
ALA A 440
LEU A 132
ILE A 364
THR A 439
 None
 1.09A 2w9hA-2w45A:
undetectable		 2w9hA-2w45A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 12 GLY A 442
ALA A 441
GLY A 461
PRO A  42
ILE A 197
 None
 1.03A 2z54A-2w45A:
undetectable		 2z54A-2w45A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 6 GLY A 406
ILE A 336
ILE A 172
ASP A 408
 None
 0.92A 3a7eA-2w45A:
undetectable		 3a7eA-2w45A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 12 LEU A  23
ILE A 127
PRO A  39
VAL A  32
VAL A 458
 None
 1.27A 3aqiB-2w45A:
undetectable		 3aqiB-2w45A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
ILE A 127
TRP A 444
 None
 1.17A 3e68A-2w45A:
undetectable		 3e68A-2w45A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
ILE A 127
TRP A 444
 None
 1.19A 3e6tB-2w45A:
undetectable		 3e6tB-2w45A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.70A 3k4vA-2w45A:
undetectable		 3k4vA-2w45A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.78A 3k4vD-2w45A:
undetectable		 3k4vD-2w45A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 5 ARG A 434
LEU A 359
ILE A 197
PHE A 198
 None
 1.30A 3ln1D-2w45A:
undetectable		 3ln1D-2w45A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 6 LEU A 323
PHE A 258
ILE A 262
THR A 389
 None
 1.11A 3mdrA-2w45A:
undetectable		 3mdrA-2w45A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.53A 3ndtA-2w45A:
undetectable		 3ndtA-2w45A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.81A 3nduD-2w45A:
undetectable		 3nduD-2w45A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 TYR A 362
GLY A 366
ASP A 367
 None
 0.60A 3ou6C-2w45A:
undetectable		 3ou6C-2w45A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.74A 3pwrA-2w45A:
undetectable		 3pwrA-2w45A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 ARG A  45
VAL A  32
THR A 454
 None
 0.76A 3tl9A-2w45A:
undetectable		 3tl9A-2w45A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 10 ARG A 298
VAL A 270
GLU A 271
ASN A 263
ILE A 262
 None
 1.17A 3uayA-2w45A:
undetectable		 3uayA-2w45A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 12 PHE A 144
LEU A  23
ILE A 127
PRO A  39
VAL A  32
 None
 1.37A 3w1wA-2w45A:
undetectable		 3w1wA-2w45A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 12 LEU A  23
ILE A 127
PRO A  39
VAL A  32
VAL A 458
 None
 1.19A 3w1wB-2w45A:
undetectable		 3w1wB-2w45A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 12 PHE A 144
LEU A  23
ILE A 127
PRO A  39
VAL A  32
 None
 1.41A 3w1wB-2w45A:
undetectable		 3w1wB-2w45A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 8 ARG A 298
LEU A 278
ARG A 351
GLU A 281
 None
 1.23A 3zmdA-2w45A:
undetectable
3zmdB-2w45A:
undetectable		 3zmdA-2w45A:
14.29
3zmdB-2w45A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		3 / 3 TYR A 284
PHE A 391
ARG A 229
 None
 1.20A 4g19D-2w45A:
undetectable		 4g19D-2w45A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 6 TYR A 232
THR A 269
PRO A 268
PHE A 258
 None
 1.47A 4kf9A-2w45A:
undetectable		 4kf9A-2w45A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 6 LYS A 231
ARG A 229
GLY A 282
ASP A 283
 None
 1.34A 5hp1A-2w45A:
undetectable		 5hp1A-2w45A:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HSW_A_ACTA501_0
(ORF 37)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		4 / 5 SER A 128
SER A 129
SER A 130
SER A 201
 None
 0.68A 5hswA-2w45A:
44.0		 5hswA-2w45A:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2w45 ALKALINE EXONUCLEASE
(Human
gammaherpesvirus
4) 		5 / 9 TYR A 368
ILE A 191
LEU A 122
THR A 110
ARG A 111
 None
 1.48A 5ifuB-2w45A:
undetectable		 5ifuB-2w45A:
21.60