SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2w47 LIPOLYTIC ENZYME,
G-D-S-L
(Ruminiclostridiu
m
thermocellum) 		4 / 6 VAL A  79
VAL A  46
ASN A 108
ASN A  75
 None
 0.94A 1e06A-2w47A:
undetectable		 1e06A-2w47A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2w47 LIPOLYTIC ENZYME,
G-D-S-L
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLN A   8
ILE A  14
SER A  29
TYR A  31
 None
 1.36A 2xz5D-2w47A:
undetectable
2xz5E-2w47A:
undetectable		 2xz5D-2w47A:
19.82
2xz5E-2w47A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 2w47 LIPOLYTIC ENZYME,
G-D-S-L
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A  66
ASN A  62
ARG A  68
PRO A  69
 None
None
UNF  A1138 (-2.9A)
None
 1.37A 3vxiA-2w47A:
undetectable		 3vxiA-2w47A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2w47 LIPOLYTIC ENZYME,
G-D-S-L
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASN A 108
GLU A  43
ILE A 110
ASN A  77
 None
 1.01A 4d39B-2w47A:
undetectable		 4d39B-2w47A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2w47 LIPOLYTIC ENZYME,
G-D-S-L
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A  32
TYR A 125
ILE A   6
VAL A  46
 None
 0.83A 4ma7A-2w47A:
undetectable		 4ma7A-2w47A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2w47 LIPOLYTIC ENZYME,
G-D-S-L
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A  34
TYR A  41
GLU A  43
PHE A  58
 None
 1.05A 5aclA-2w47A:
2.4		 5aclA-2w47A:
20.41