SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 VAL A 304
LEU A 303
LEU A 102
GLY A 211
LEU A 124
 None
None
None
GOL  A1316 (-3.1A)
None
 1.03A 1cqeA-2w48A:
undetectable		 1cqeA-2w48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 VAL A 304
LEU A 303
LEU A 102
GLY A 211
LEU A 124
 None
None
None
GOL  A1316 (-3.1A)
None
 1.03A 1cqeB-2w48A:
undetectable		 1cqeB-2w48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 11 ILE A 251
SER A 214
GLY A 242
ASN A 236
GLY A 290
 None
 1.31A 1ho5A-2w48A:
undetectable		 1ho5A-2w48A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 4 HIS A 224
ALA A 225
PHE A 226
GLY A 228
 None
None
MPD  A1317 (-4.0A)
None
 0.95A 1mjoA-2w48A:
undetectable		 1mjoA-2w48A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 7 GLY A 293
ILE A 251
PRO A 215
ALA A 216
 None
 0.72A 1n49A-2w48A:
undetectable		 1n49A-2w48A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 SER A 123
LEU A 106
GLY A 280
VAL A  79
ALA A  78
 None
 1.06A 1tsnA-2w48A:
undetectable		 1tsnA-2w48A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 VAL A 304
LEU A 303
LEU A 102
GLY A 211
LEU A 124
 None
None
None
GOL  A1316 (-3.1A)
None
 0.97A 2aylB-2w48A:
undetectable		 2aylB-2w48A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 MET A  95
LEU A  92
ILE A 291
ALA A 120
THR A 309
 None
 1.20A 2japA-2w48A:
undetectable		 2japA-2w48A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 MET A  95
LEU A  92
ILE A 291
ALA A 120
THR A 309
 None
 1.20A 2japB-2w48A:
undetectable		 2japB-2w48A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 MET A  95
LEU A  92
ILE A 291
ALA A 120
THR A 309
 None
 1.22A 2japC-2w48A:
undetectable		 2japC-2w48A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 MET A  95
LEU A  92
ILE A 291
ALA A 120
THR A 309
 None
 1.22A 2japD-2w48A:
undetectable		 2japD-2w48A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 7 TRP A 202
SER A 246
CYH A 245
ILE A 267
 None
MPD  A1317 ( 4.0A)
GOL  A1316 (-4.2A)
None
 1.26A 2xz5A-2w48A:
undetectable
2xz5B-2w48A:
undetectable		 2xz5A-2w48A:
19.14
2xz5B-2w48A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 10 ILE A 212
GLY A 293
ILE A 251
PRO A 215
ALA A 216
 None
 1.01A 3ekwA-2w48A:
undetectable		 3ekwA-2w48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 VAL A 304
LEU A 303
LEU A 102
GLY A 211
LEU A 124
 None
None
None
GOL  A1316 (-3.1A)
None
 1.00A 3n8wA-2w48A:
undetectable		 3n8wA-2w48A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 8 ALA A 100
VAL A 103
ASP A 104
LEU A 107
 None
 0.31A 3roxA-2w48A:
4.3		 3roxA-2w48A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		3 / 3 HIS A  98
GLU A  66
ASN A  60
 None
 0.83A 4bupB-2w48A:
undetectable		 4bupB-2w48A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 7 LEU A 179
GLY A 228
TYR A 227
SER A 232
 MPD  A1317 (-3.9A)
None
MPD  A1317 (-4.4A)
None
 1.02A 4cp3A-2w48A:
undetectable
4cp3B-2w48A:
undetectable		 4cp3A-2w48A:
18.62
4cp3B-2w48A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 LEU A 179
ILE A 143
MET A 269
GLU A 268
ILE A 267
 MPD  A1317 (-3.9A)
None
None
None
None
 0.97A 4ltwA-2w48A:
undetectable		 4ltwA-2w48A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 GLY A 253
GLY A 254
THR A 258
LEU A 255
GLY A 293
 None
 0.95A 4o33A-2w48A:
2.8		 4o33A-2w48A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 GLY A 253
GLY A 254
THR A 258
LEU A 255
GLY A 293
 None
 0.88A 4o3fA-2w48A:
2.5		 4o3fA-2w48A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 5 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.45A 4w5oA-2w48A:
0.0		 4w5oA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.47A 4w5qA-2w48A:
undetectable		 4w5qA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.43A 4w5rA-2w48A:
undetectable		 4w5rA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.44A 4w5tA-2w48A:
undetectable		 4w5tA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.43A 4z4cA-2w48A:
undetectable		 4z4cA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 5 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.43A 4z4dA-2w48A:
0.0		 4z4dA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 5 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.44A 4z4eA-2w48A:
0.0		 4z4eA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.49A 4z4fA-2w48A:
undetectable		 4z4fA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 5 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.44A 4z4gA-2w48A:
undetectable		 4z4gA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.44A 4z4iA-2w48A:
undetectable		 4z4iA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 GLY A 293
GLY A 211
GLY A 213
GLY A 290
VAL A 121
 None
GOL  A1316 (-3.1A)
GOL  A1316 ( 3.7A)
None
None
 1.03A 5ehiC-2w48A:
undetectable		 5ehiC-2w48A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 12 VAL A 304
LEU A 303
LEU A 102
GLY A 211
LEU A 124
 None
None
None
GOL  A1316 (-3.1A)
None
 1.00A 5ikrB-2w48A:
undetectable		 5ikrB-2w48A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		3 / 3 HIS A  98
GLU A  66
ASN A  60
 None
 0.74A 5wbvA-2w48A:
undetectable		 5wbvA-2w48A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		3 / 3 HIS A  98
GLU A  66
ASN A  60
 None
 0.73A 5wbvB-2w48A:
undetectable		 5wbvB-2w48A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 9 GLY A 242
TYR A 227
VAL A 240
GLY A 213
PRO A 215
 None
MPD  A1317 (-4.4A)
None
GOL  A1316 ( 3.7A)
None
 1.06A 5zniA-2w48A:
undetectable		 5zniA-2w48A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 2w48 SORBITOL OPERON
REGULATOR
(Klebsiella
pneumoniae) 		5 / 9 VAL A 137
GLY A 110
ILE A 279
LEU A 209
ASP A 104
 None
 1.28A 6c2mC-2w48A:
undetectable		 6c2mC-2w48A:
12.38