SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 11 PHE 0  28
ILE 0  36
LEU 0  41
MET 0  45
LEU 0  48
 None
 0.78A 1dtlA-2w490:
13.1		 1dtlA-2w490:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 11 PHE 0  28
ILE 0  36
MET 0  45
LEU 0  48
VAL 0  64
 None
 0.98A 1dtlA-2w490:
13.1		 1dtlA-2w490:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 8 MET 0  45
GLN 0  50
PRO 0  52
GLU 0  56
 None
 0.50A 1dtlA-2w490:
13.1		 1dtlA-2w490:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 12 PHE 0  28
ILE 0  36
LEU 0  41
LEU 0  48
GLU 0  63
MET 0  81
 None
 0.86A 1lxfC-2w490:
11.2		 1lxfC-2w490:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 12 PHE 0  28
ILE 0  36
LEU 0  41
LEU 0  48
ILE 0  61
GLU 0  63
 None
 0.81A 1lxfC-2w490:
11.2		 1lxfC-2w490:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 12 PHE 0  28
ILE 0  36
LEU 0  41
MET 0  45
LEU 0  48
ILE 0  61
 None
 0.80A 1lxfC-2w490:
11.2		 1lxfC-2w490:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 12 PHE 0  28
ILE 0  36
LEU 0  41
MET 0  45
LEU 0  48
MET 0  81
 None
 0.76A 1lxfC-2w490:
11.2		 1lxfC-2w490:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 10 MET 0  45
LEU 0  48
GLN 0  50
GLU 0  56
MET 0  80
MET 0  81
 None
 0.95A 1wrkA-2w490:
13.2
1wrkB-2w490:
13.0		 1wrkA-2w490:
64.77
1wrkB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 9 PHE 0  21
PHE 0  28
VAL 0  44
LEU 0  48
PHE 0  77
MET 0  81
 None
 1.18A 1wrkA-2w490:
13.2
1wrkB-2w490:
13.0		 1wrkA-2w490:
64.77
1wrkB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 10 MET 0  45
LEU 0  48
GLN 0  50
MET 0  80
MET 0  81
 None
 0.86A 1wrkA-2w490:
13.2
1wrkB-2w490:
13.0		 1wrkA-2w490:
64.77
1wrkB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 5 PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.85A 1wrkB-2w490:
13.0		 1wrkB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 9 MET 0  45
LEU 0  48
GLN 0  50
GLU 0  56
MET 0  80
 None
 0.98A 1wrlA-2w490:
13.3
1wrlB-2w490:
13.5		 1wrlA-2w490:
64.77
1wrlB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 7 PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
VAL 0  82
 None
 0.89A 1wrlA-2w490:
13.3
1wrlB-2w490:
13.5		 1wrlA-2w490:
64.77
1wrlB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 9 MET 0  45
LEU 0  48
GLN 0  50
GLU 0  56
MET 0  80
MET 0  81
 None
 0.85A 1wrlA-2w490:
13.3
1wrlB-2w490:
13.5		 1wrlA-2w490:
64.77
1wrlB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 6 PHE 0  28
VAL 0  44
LEU 0  48
PHE 0  77
MET 0  81
 None
 1.19A 1wrlB-2w490:
13.5		 1wrlB-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC206_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 9 MET 0  45
LEU 0  48
GLN 0  50
GLU 0  56
MET 0  80
MET 0  81
 None
 0.87A 1wrlC-2w490:
13.2
1wrlD-2w490:
13.0		 1wrlC-2w490:
64.77
1wrlD-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 5 PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.91A 1wrlC-2w490:
13.2		 1wrlC-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 10 MET 0  45
LEU 0  48
GLN 0  50
GLU 0  56
MET 0  80
MET 0  81
 None
 0.96A 1wrlC-2w490:
13.2
1wrlD-2w490:
13.0		 1wrlC-2w490:
64.77
1wrlD-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 8 LEU 0  13
PHE 0  21
PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 1.00A 1wrlC-2w490:
13.2
1wrlD-2w490:
13.0		 1wrlC-2w490:
64.77
1wrlD-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 7 PHE 0  21
PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.98A 1wrlE-2w490:
13.0		 1wrlE-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		6 / 10 MET 0  45
LEU 0  48
GLN 0  50
GLU 0  56
MET 0  80
MET 0  81
 None
 0.71A 1wrlE-2w490:
13.0
1wrlF-2w490:
12.9		 1wrlE-2w490:
64.77
1wrlF-2w490:
64.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		5 / 7 PHE 0  21
PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.93A 1wrlE-2w490:
13.0
1wrlF-2w490:
12.9		 1wrlE-2w490:
64.77
1wrlF-2w490:
64.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 6 ARG 0  10
ASP 0  26
GLU 0  40
LEU 0  78
 None
None
CA  01003 (-2.3A)
None
 1.35A 4ax8A-2w490:
undetectable		 4ax8A-2w490:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2w49 TROPOMYOSIN ALPHA-1
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 LEU A 242
GLU A 243
SER A 245
 None
 0.78A 4ccqA-2w49A:
undetectable		 4ccqA-2w49A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 7 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.88A 5hieA-2w490:
undetectable		 5hieA-2w490:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 7 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.87A 5hieB-2w490:
undetectable		 5hieB-2w490:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w49 TROPONIN C, SKELETAL
MUSCLE
(Gallus
gallus) 		4 / 8 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.86A 5hieD-2w490:
undetectable		 5hieD-2w490:
20.68