SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HTQ_A_ZMRA472_1 (NEURAMINIDASE)	2w4e	MUTT/NUDIX FAMILY PROTEIN (Deinococcus radiodurans)	5 / 12	ARG A 81 GLU A 113 GLU A 112 GLU A 109 ARG A 108	None	1.46A	2htqA-2w4eA: undetectable	2htqA-2w4eA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GV1_B_BEZB303_0 (DISULFIDE INTERCHANGE PROTEIN)	2w4e	MUTT/NUDIX FAMILY PROTEIN (Deinococcus radiodurans)	4 / 4	LEU A 187 ALA A 74 VAL A 68 PRO A 67	None	1.11A	3gv1B-2w4eA: undetectable	3gv1B-2w4eA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RAE_F_LFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	2w4e	MUTT/NUDIX FAMILY PROTEIN (Deinococcus radiodurans)	3 / 4	SER A 134 GLY A 95 GLU A 113	None	0.69A	3raeA-2w4eA: undetectable 3raeC-2w4eA: undetectable	3raeA-2w4eA: 13.50 3raeC-2w4eA: 19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RAE_H_LFXH101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	2w4e	MUTT/NUDIX FAMILY PROTEIN (Deinococcus radiodurans)	4 / 5	SER A 134 GLY A 95 GLU A 113 GLU A 109	None	1.30A	3raeB-2w4eA: undetectable 3raeD-2w4eA: undetectable	3raeB-2w4eA: 13.50 3raeD-2w4eA: 19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4D_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2w4e	MUTT/NUDIX FAMILY PROTEIN (Deinococcus radiodurans)	4 / 6	ARG A 81 ILE A 159 ILE A 88 ASP A 180	None	1.17A	4z4dA-2w4eA: undetectable	4z4dA-2w4eA: 10.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2HTQ_A_ZMRA472_1","NEURAMINIDASE","2w4e","MUTT\/NUDIX FAMILY PROTEIN","Deinococcus radiodurans",5,"ARG A  81;GLU A 113;GLU A 112;GLU A 109;ARG A 108","None","1.46A","2htqA-2w4eA:undetectable","2htqA-2w4eA:17.31"],["3GV1_B_BEZB303_0","DISULFIDE INTERCHANGE PROTEIN","2w4e","MUTT\/NUDIX FAMILY PROTEIN","Deinococcus radiodurans",4,"LEU A 187;ALA A  74;VAL A  68;PRO A  67","None","1.11A","3gv1B-2w4eA:undetectable","3gv1B-2w4eA:20.96"],["3RAE_F_LFXF101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B","2w4e","MUTT\/NUDIX FAMILY PROTEIN","Deinococcus radiodurans",3,"SER A 134;GLY A  95;GLU A 113","None","0.69A","3raeA-2w4eA:undetectable;3raeC-2w4eA:undetectable","3raeA-2w4eA:13.50;3raeC-2w4eA:19.40"],["3RAE_H_LFXH101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B","2w4e","MUTT\/NUDIX FAMILY PROTEIN","Deinococcus radiodurans",4,"SER A 134;GLY A  95;GLU A 113;GLU A 109","None","1.30A","3raeB-2w4eA:undetectable;3raeD-2w4eA:undetectable","3raeB-2w4eA:13.50;3raeD-2w4eA:19.40"],["4Z4D_A_IPHA902_0","PROTEIN ARGONAUTE-2","2w4e","MUTT\/NUDIX FAMILY PROTEIN","Deinococcus radiodurans",4,"ARG A  81;ILE A 159;ILE A  88;ASP A 180","None","1.17A","4z4dA-2w4eA:undetectable","4z4dA-2w4eA:10.50"]]