SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		5 / 9 ALA A 799
LEU A 738
ARG A 733
ILE A 760
LEU A 788
 None
None
None
None
EDO  A1822 ( 4.7A)
 1.44A 1ereA-2w4fA:
undetectable		 1ereA-2w4fA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		5 / 9 ALA A 799
LEU A 738
ARG A 733
ILE A 760
LEU A 788
 None
None
None
None
EDO  A1822 ( 4.7A)
 1.46A 1ereC-2w4fA:
undetectable		 1ereC-2w4fA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		5 / 9 ALA A 799
LEU A 738
ARG A 733
ILE A 760
LEU A 788
 None
None
None
None
EDO  A1822 ( 4.7A)
 1.43A 1ereD-2w4fA:
undetectable		 1ereD-2w4fA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 5 LYS A 725
LEU A 727
GLU A 725
LEU A 729
 None
 1.16A 1eta2-2w4fA:
undetectable		 1eta2-2w4fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 EDO  A1821 ( 4.4A)
None
None
None
 1.20A 1mj2B-2w4fA:
undetectable		 1mj2B-2w4fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 EDO  A1821 ( 4.4A)
None
None
None
 1.19A 1mj2D-2w4fA:
undetectable		 1mj2D-2w4fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 EDO  A1821 ( 4.4A)
None
None
None
 1.18A 1mjoB-2w4fA:
undetectable		 1mjoB-2w4fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 EDO  A1821 ( 4.4A)
None
None
None
 1.19A 1mjoA-2w4fA:
undetectable		 1mjoA-2w4fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 EDO  A1821 ( 4.4A)
None
None
None
 1.19A 1mjoD-2w4fA:
undetectable		 1mjoD-2w4fA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		5 / 11 LEU A 738
GLY A 739
ILE A 740
SER A 741
ILE A 742
 None
 0.80A 2kawA-2w4fA:
10.8		 2kawA-2w4fA:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		5 / 12 ILE A 740
LEU A 780
GLY A 773
ALA A 772
GLY A 767
 None
 0.93A 3vaqB-2w4fA:
undetectable		 3vaqB-2w4fA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2w4f PROTEIN LAP4
(Homo
sapiens) 		4 / 7 LEU A 732
ALA A 772
VAL A 811
ILE A 731
 None
 0.94A 3wsjB-2w4fA:
undetectable		 3wsjB-2w4fA:
20.80