SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 7 LEU M 103
TYR M 104
HIS M 688
THR M 117
 None
 1.39A 1afsA-2w4gM:
undetectable		 1afsA-2w4gM:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 7 LEU M 103
TYR M 104
HIS M 688
THR M 117
 None
 1.39A 1afsB-2w4gM:
undetectable		 1afsB-2w4gM:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 PHE M 475
LEU M 603
TYR M 611
GLY M 427
ALA M 430
 None
 1.10A 1fe2A-2w4gM:
0.0		 1fe2A-2w4gM:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 PHE M 475
LEU M 603
TYR M 611
GLY M 427
ALA M 430
 None
 1.08A 1igxA-2w4gM:
undetectable		 1igxA-2w4gM:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 9 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.48A 1mj2A-2w4gM:
undetectable		 1mj2A-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 9 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.48A 1mj2C-2w4gM:
undetectable		 1mj2C-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 9 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.49A 1mjlA-2w4gM:
undetectable
1mjlB-2w4gM:
undetectable		 1mjlA-2w4gM:
8.88
1mjlB-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 9 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.49A 1mjoC-2w4gM:
0.0		 1mjoC-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 10 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.49A 1mjqG-2w4gM:
undetectable
1mjqH-2w4gM:
undetectable		 1mjqG-2w4gM:
8.88
1mjqH-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 8 ARG M 245
GLU M 271
GLN M 278
SER M 474
 None
 1.27A 1nx9C-2w4gM:
undetectable		 1nx9C-2w4gM:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 8 ARG M 245
GLU M 271
GLN M 278
SER M 474
 None
 1.28A 1nx9D-2w4gM:
undetectable		 1nx9D-2w4gM:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 7 LEU M 664
PHE M 249
LEU M 176
PHE M 458
 None
 1.05A 1wrlE-2w4gM:
undetectable
1wrlF-2w4gM:
undetectable		 1wrlE-2w4gM:
7.24
1wrlF-2w4gM:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 4 ILE M 480
ASP M 463
LEU M 660
ARG M 245
 None
 1.47A 2a7qA-2w4gM:
undetectable		 2a7qA-2w4gM:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 11 THR M 186
ALA M 225
ILE M 340
ASP M 220
PRO M 227
 None
 1.10A 2admA-2w4gM:
undetectable		 2admA-2w4gM:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2w4g MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus;
Gallus
gallus) 		4 / 8 LYS M 742
PHE M 720
ASP C  95
TYR C 139
 None
 0.93A 2aouA-2w4gM:
undetectable		 2aouA-2w4gM:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 THR M 355
ASN M 234
ILE M 351
ILE M 338
LEU M 270
 None
 1.03A 2rlcA-2w4gM:
undetectable		 2rlcA-2w4gM:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 LEU M 487
ILE M 480
ALA M 465
ARG M 251
GLU M 266
 None
 1.20A 2v0mC-2w4gM:
undetectable		 2v0mC-2w4gM:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 8 ILE M 287
PHE M 438
TYR M 434
GLY M 233
 None
 0.97A 2vdbA-2w4gM:
undetectable		 2vdbA-2w4gM:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 MET C 147
PHE C  87
ALA M 729
PHE M 797
ARG M 725
 None
 1.39A 3aobC-2w4gC:
undetectable		 3aobC-2w4gC:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 MET C 147
PHE C  87
ALA M 729
PHE M 797
ARG M 725
 None
 1.46A 3aodC-2w4gC:
undetectable		 3aodC-2w4gC:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 8 ALA M 201
LEU M 260
GLN M 194
ILE M 155
 None
 0.79A 3cldB-2w4gM:
undetectable		 3cldB-2w4gM:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		3 / 3 ILE M 175
PHE M 196
HIS M 668
 None
 0.59A 3h0aA-2w4gM:
1.2		 3h0aA-2w4gM:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 ALA M 651
GLU M 537
LEU M 536
PHE M 533
SER M 273
 None
 1.22A 3ia4D-2w4gM:
undetectable		 3ia4D-2w4gM:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 ASN M 599
GLU M 537
PRO M 602
GLY M 531
ILE M 526
 None
 1.29A 3jb2A-2w4gM:
undetectable		 3jb2A-2w4gM:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 ASN M 599
SER M 650
PRO M 602
GLY M 531
ILE M 526
 None
 1.48A 3jb2A-2w4gM:
undetectable		 3jb2A-2w4gM:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		3 / 3 GLU M 527
GLU M 655
ASN M 658
 None
 0.86A 3lp9B-2w4gM:
undetectable
3lp9D-2w4gM:
undetectable		 3lp9B-2w4gM:
14.80
3lp9D-2w4gM:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 11 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.22A 3mbhA-2w4gC:
undetectable		 3mbhA-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.19A 3mbhB-2w4gC:
undetectable		 3mbhB-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.23A 3mbhC-2w4gC:
undetectable		 3mbhC-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.20A 3mbhD-2w4gC:
undetectable		 3mbhD-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.21A 3mbhE-2w4gC:
undetectable		 3mbhE-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 11 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.25A 3mbhF-2w4gC:
undetectable		 3mbhF-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2w4g MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus;
Gallus
gallus) 		5 / 12 GLU C  85
GLY C  90
VAL M 753
ASP C  95
PHE C  94
 None
 1.25A 3qowA-2w4gC:
undetectable		 3qowA-2w4gC:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 CYH M 479
ARG M 654
ALA M 651
LEU M 536
ILE M 526
 None
 1.32A 3qt0A-2w4gM:
0.0		 3qt0A-2w4gM:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 10 ILE M 351
PHE M 343
THR M 267
ILE M 265
THR M 618
 None
 1.26A 3um5A-2w4gM:
undetectable		 3um5A-2w4gM:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 ALA M 197
LEU M 218
THR M 451
ALA M 263
ILE M 250
 None
 1.10A 3ut5B-2w4gM:
undetectable		 3ut5B-2w4gM:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		3 / 3 THR M 648
ASN M 599
GLU M 537
 None
 0.73A 3v4tA-2w4gM:
undetectable
3v4tC-2w4gM:
undetectable		 3v4tA-2w4gM:
20.05
3v4tC-2w4gM:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 7 ARG M 779
LEU M 783
ALA M 729
VAL C 123
ILE M 787
 None
 1.24A 3wsjB-2w4gM:
undetectable		 3wsjB-2w4gM:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		3 / 3 PRO M 677
TYR M 129
GLY M 684
 None
 0.66A 4g2zA-2w4gM:
undetectable		 4g2zA-2w4gM:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 7 ILE M 532
LEU M 525
LYS M 567
GLY M 560
 None
 0.82A 4hajA-2w4gM:
undetectable		 4hajA-2w4gM:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 8 ILE M 532
LEU M 525
LYS M 567
GLY M 560
 None
 0.86A 4hb6A-2w4gM:
undetectable		 4hb6A-2w4gM:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 7 ILE M 532
LEU M 525
LYS M 567
GLY M 560
 None
 0.83A 4hc3A-2w4gM:
undetectable		 4hc3A-2w4gM:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 8 ILE M 193
LYS M 190
ILE M 222
ASN M 226
ALA M 225
 None
 1.17A 4ou1A-2w4gM:
undetectable		 4ou1A-2w4gM:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		6 / 10 LEU M 401
LEU M 397
VAL M 433
LEU M 619
LEU M 354
VAL M 616
 None
 1.45A 4po0A-2w4gM:
2.2		 4po0A-2w4gM:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 4 ASN M 698
VAL M 124
THR M 178
ILE M 177
 None
 1.06A 4retA-2w4gM:
undetectable		 4retA-2w4gM:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		4 / 4 ASN M 698
VAL M 124
THR M 178
ILE M 177
 None
 1.06A 4retC-2w4gM:
undetectable		 4retC-2w4gM:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		3 / 3 HIS M 494
HIS M 668
HIS M 670
 None
 0.81A 5oexA-2w4gM:
undetectable		 5oexA-2w4gM:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 10 PHE M 343
ALA M 337
LEU M 341
GLY M 342
LEU M 660
 None
 1.25A 5oy01-2w4gM:
undetectable
5oy07-2w4gM:
undetectable		 5oy01-2w4gM:
7.10
5oy07-2w4gM:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
(Gallus
gallus) 		5 / 12 LEU M 775
PHE C  87
ILE M 786
ALA M 729
ALA M 743
 None
 1.13A 5veuA-2w4gM:
undetectable		 5veuA-2w4gM:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 10 ILE M 443
ILE M 287
ALA M 231
LEU M 228
ALA M 337
 None
 1.36A 5zjiB-2w4gM:
undetectable		 5zjiB-2w4gM:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		3 / 3 TYR M 611
ASN M 604
LEU M 429
 None
 0.51A 6b58A-2w4gM:
undetectable		 6b58A-2w4gM:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 12 ILE M 704
LEU M 106
ASP M  90
GLY M 120
MET M  94
 None
 1.31A 6r2eA-2w4gM:
undetectable		 6r2eA-2w4gM:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 10 ILE M 704
LEU M 106
ASP M  90
GLY M 120
MET M  94
 None
 1.19A 6r2eB-2w4gM:
undetectable		 6r2eB-2w4gM:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
(Gallus
gallus) 		5 / 10 ILE M 704
LEU M 106
ASP M  90
GLY M 120
MET M  94
 None
 1.25A 6r2eD-2w4gM:
undetectable		 6r2eD-2w4gM:
17.31