SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 ILE A 214
LEU A  66
ASP A   7
GLY A  12
ALA A  73
None
None
DGL  A1256 (-3.5A)
None
None
1.05A 1b02A-2w4iA:
undetectable
1b02A-2w4iA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A  40
ALA A  73
ILE A  47
GLY A 180
THR A 182
DGL  A1256 (-3.4A)
None
None
None
DGL  A1256 (-3.1A)
1.08A 1c9sN-2w4iA:
undetectable
1c9sO-2w4iA:
undetectable
1c9sN-2w4iA:
14.79
1c9sO-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 GLY A  40
ALA A  73
ILE A  47
GLY A 180
THR A 182
DGL  A1256 (-3.4A)
None
None
None
DGL  A1256 (-3.1A)
1.10A 1c9sP-2w4iA:
undetectable
1c9sQ-2w4iA:
undetectable
1c9sP-2w4iA:
14.79
1c9sQ-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.03A 1c9sP-2w4iA:
undetectable
1c9sQ-2w4iA:
undetectable
1c9sP-2w4iA:
14.79
1c9sQ-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 SER A  14
VAL A  15
GLY A  12
GLY A 211
LEU A  78
None
0.90A 1fduA-2w4iA:
2.6
1fduA-2w4iA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 1gtfJ-2w4iA:
undetectable
1gtfK-2w4iA:
undetectable
1gtfJ-2w4iA:
14.79
1gtfK-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.02A 1gtfQ-2w4iA:
undetectable
1gtfR-2w4iA:
undetectable
1gtfQ-2w4iA:
14.79
1gtfR-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.04A 1gtfS-2w4iA:
undetectable
1gtfT-2w4iA:
undetectable
1gtfS-2w4iA:
14.79
1gtfT-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.05A 1gtnT-2w4iA:
undetectable
1gtnU-2w4iA:
undetectable
1gtnT-2w4iA:
14.79
1gtnU-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.07A 1utdE-2w4iA:
undetectable
1utdF-2w4iA:
undetectable
1utdE-2w4iA:
14.79
1utdF-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.07A 1utdH-2w4iA:
undetectable
1utdI-2w4iA:
undetectable
1utdH-2w4iA:
14.79
1utdI-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 HIS A 183
THR A 119
THR A 116
GLY A 180
THR A 182
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
None
DGL  A1256 (-3.1A)
1.04A 1utdS-2w4iA:
undetectable
1utdT-2w4iA:
undetectable
1utdS-2w4iA:
14.79
1utdT-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 11 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.07A 1utdL-2w4iA:
undetectable
1utdV-2w4iA:
undetectable
1utdL-2w4iA:
14.79
1utdV-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 VAL A  90
ILE A  29
LEU A  19
VAL A  15
LEU A 218
None
1.02A 3gwxA-2w4iA:
undetectable
3gwxA-2w4iA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 GLY A 180
ASN A  71
ALA A 188
LEU A 112
LEU A 207
None
DGL  A1256 (-4.0A)
None
None
None
1.07A 3p2kC-2w4iA:
undetectable
3p2kC-2w4iA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 ILE A  93
ASN A  71
TYR A 125
SER A 210
LEU A  19
None
DGL  A1256 (-4.0A)
None
None
None
1.15A 4a84A-2w4iA:
undetectable
4a84A-2w4iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 THR A 182
PHE A  25
VAL A   5
ALA A  22
VAL A 215
DGL  A1256 (-3.1A)
None
None
None
None
1.14A 4df3A-2w4iA:
3.3
4df3A-2w4iA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 THR A 182
PHE A  25
VAL A   5
ALA A  22
VAL A 215
DGL  A1256 (-3.1A)
None
None
None
None
1.10A 4df3B-2w4iA:
2.0
4df3B-2w4iA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
4 / 8 SER A 143
CYH A  70
THR A  72
GLY A 180
None
DGL  A1256 (-3.1A)
DGL  A1256 (-3.8A)
None
0.78A 4fo4A-2w4iA:
undetectable
4fo4A-2w4iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
4 / 8 SER A 143
CYH A  70
THR A  72
GLY A 180
None
DGL  A1256 (-3.1A)
DGL  A1256 (-3.8A)
None
0.77A 4fo4B-2w4iA:
undetectable
4fo4B-2w4iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
4 / 6 GLU A 235
PHE A  58
TYR A  31
HIS A 237
None
1.39A 4uciA-2w4iA:
undetectable
4uciA-2w4iA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
4 / 7 GLU A 235
PHE A  58
TYR A  31
HIS A 237
None
1.30A 4uciB-2w4iA:
undetectable
4uciB-2w4iA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 LEU A  19
GLU A 251
GLY A  12
ALA A  69
ILE A 214
None
1.29A 4xe5A-2w4iA:
undetectable
4xe5A-2w4iA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
4 / 9 SER A 210
ALA A 213
GLU A 216
LEU A 206
None
0.54A 4xtaA-2w4iA:
undetectable
4xtaA-2w4iA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5eevA-2w4iA:
undetectable
5eevB-2w4iA:
undetectable
5eevA-2w4iA:
14.79
5eevB-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5eewA-2w4iA:
undetectable
5eewB-2w4iA:
undetectable
5eewA-2w4iA:
14.79
5eewB-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5eexA-2w4iA:
undetectable
5eexB-2w4iA:
undetectable
5eexA-2w4iA:
14.79
5eexB-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5eeyA-2w4iA:
undetectable
5eeyB-2w4iA:
undetectable
5eeyA-2w4iA:
14.79
5eeyB-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5eezA-2w4iA:
undetectable
5eezB-2w4iA:
undetectable
5eezA-2w4iA:
14.79
5eezB-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5ef0A-2w4iA:
undetectable
5ef0B-2w4iA:
undetectable
5ef0A-2w4iA:
14.79
5ef0B-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5ef1A-2w4iA:
undetectable
5ef1B-2w4iA:
undetectable
5ef1A-2w4iA:
14.79
5ef1B-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.10A 5ef2A-2w4iA:
undetectable
5ef2B-2w4iA:
undetectable
5ef2A-2w4iA:
14.79
5ef2B-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 10 GLY A 180
THR A 182
HIS A 183
THR A 119
THR A 116
None
DGL  A1256 (-3.1A)
DGL  A1256 ( 4.5A)
None
DGL  A1256 (-3.5A)
1.11A 5ef3A-2w4iA:
undetectable
5ef3B-2w4iA:
undetectable
5ef3A-2w4iA:
14.79
5ef3B-2w4iA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
5 / 12 ILE A 214
LEU A  66
ASP A   7
GLY A  12
ALA A  73
None
None
DGL  A1256 (-3.5A)
None
None
1.07A 5j7wD-2w4iA:
undetectable
5j7wD-2w4iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)
2w4i GLUTAMATE RACEMASE
(Helicobacter
pylori)
3 / 3 LEU A  16
SER A  14
PHE A  13
None
0.65A 6fgcA-2w4iA:
3.9
6fgcA-2w4iA:
19.58